VEGF121-conjugated mesoporous silica nanoparticle: A tumor targeted drug delivery system

ACS Applied Materials and Interfaces

Volumn 6, Issue 23, 2014, Pages 21677-21685

  Goel, Shreya ^a   Chen, Feng ^b   Hong, Hao ^b   Valdovinos, Hector F ^c   Hernandez, Reinier ^c   Shi, Sixiang ^a   Barnhart, Todd E ^c   Cai, Weibo ^a,b,c,d  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

Author keywords

drug delivery; mesoporous silica nanoparticle; positron emission tomography; vasculature targeting; VEGFR

Indexed keywords

CONTROLLED DRUG DELIVERY; DRUG DELIVERY; MEDICAL NANOTECHNOLOGY; MESOPOROUS MATERIALS; NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; POSITRONS; SILICA; SILICA NANOPARTICLES; THERANOSTICS; TUMORS;

DRUG ADMINISTRATION; MESOPOROUS SILICA NANOPARTICLES; THERANOSTIC NANOMEDICINE; THERAPEUTIC EFFICACY; TUMOR-TARGETED DRUG DELIVERIES; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULATURE; VEGFR;

TARGETED DRUG DELIVERY;

INDOLE DERIVATIVE; NANOPARTICLE; PYRROLE DERIVATIVE; SILICON DIOXIDE; SUNITINIB; VASCULOTROPIN RECEPTOR 1;

ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG SCREENING; GENETICS; GLIOBLASTOMA; GLIOMA; HUMAN; MOUSE; PATHOLOGY;

ANIMALS; DRUG DELIVERY SYSTEMS; GLIOBLASTOMA; GLIOMA; HUMANS; INDOLES; MICE; NANOPARTICLES; PYRROLES; SILICON DIOXIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84917682044     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am506849p     Document Type: Article

References (39)

1. Hanahan, D.; Weinberg, R. A. Hallmarks of Cancer: The Next Generation Cell 2011, 144, 646-674
2. Cai, W.; Chen, X. Multimodality Molecular Imaging of Tumor Angiogenesis J. Nucl. Med. 2008, 49 (Suppl 2) 113S-128S
3. Bergers, G.; Benjamin, L. E. Tumorigenesis and the Angiogenic Switch Nat. Rev. Cancer 2003, 3, 401-410
4. Cristofanilli, M.; Charnsangavej, C.; Hortobagyi, G. N. Angiogenesis Modulation in Cancer Research: Novel Clinical Approaches Nat. Rev. Drug Discov 2002, 1, 415-426
5. Hicklin, D. J.; Ellis, L. M. Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis J. Clin. Oncol. 2005, 23, 1011-1027
6. Ellis, L. M.; Hicklin, D. J. VEGF-Targeted Therapy: Mechanisms of Anti-Tumour Activity Nat. Rev. Cancer 2008, 8, 579-591
7. Chan, C.; Sandhu, J.; Guha, A.; Scollard, D. A.; Wang, J.; Chen, P.; Bai, K.; Lee, L.; Reilly, R. M. A Human Transferrin-Vascular Endothelial Growth Factor (HNTF-VEGF) Fusion Protein Containing an Integrated Binding Site for (111) in for Imaging Tumor Angiogenesis J. Nucl. Med. 2005, 46, 1745-1752
8. Hsu, A. R.; Cai, W.; Veeravagu, A.; Mohamedali, K. A.; Chen, K.; Kim, S.; Vogel, H.; Hou, L. C.; Tse, V.; Rosenblum, M. G.; Chen, X. Multimodality Molecular Imaging of Glioblastoma Growth Inhibition with Vasculature-Targeting Fusion Toxin VEGF121/RGEL J. Nucl. Med. 2007, 48, 445-454
9. Cai, W.; Chen, K.; Mohamedali, K. A.; Cao, Q.; Gambhir, S. S.; Rosenblum, M. G.; Chen, X. PET of Vascular Endothelial Growth Factor Receptor Expression J. Nucl. Med. 2006, 47, 2048-2056
10. Zhang, Y.; Hong, H.; Niu, G.; Valdovinos, H. F.; Orbay, H.; Nayak, T. R.; Chen, X.; Barnhart, T. E.; Cai, W. Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor Expression with (61)Cu-Labeled Lysine-Tagged VEGF(121) Mol. Pharmaceutics 2012, 9, 3586-3594
11. Zhang, Y.; Hong, H.; Engle, J. W.; Yang, Y.; Barnhart, T. E.; Cai, W. Positron Emission Tomography and near-Infrared Fluorescence Imaging of Vascular Endothelial Growth Factor with Dual-Labeled Bevacizumab Am. J. Nucl. Med. Mol. Imaging 2012, 2, 1-13
12. Hao, G.; Hajibeigi, A.; Leon-Rodriguez, L. M.; Oz, O. K.; Sun, X. Peptoid-based PET Imaging of Vascular Endothelial Growth Factor Receptor (VEGFR) Expression Am. J. Nucl. Med. Mol. Imaging 2011, 1, 65-75
13. Wang, H.; Chen, K.; Niu, G.; Chen, X. Site-Specifically Biotinylated VEGF(121) for near-Infrared Fluorescence Imaging of Tumor Angiogenesis Mol. Pharmaceutics 2009, 6, 285-294
14. Ferris, D. P.; Lu, J.; Gothard, C.; Yanes, R.; Thomas, C. R.; Olsen, J. C.; Stoddart, J. F.; Tamanoi, F.; Zink, J. I. Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells Small 2011, 7, 1816-1826
15. Rosenholm, J. M.; Mamaeva, V.; Sahlgren, C.; Linden, M. Nanoparticles in Targeted Cancer Therapy: Mesoporous Silica Nanoparticles Entering Preclinical Development Stage Nanomedicine (London, U. K.) 2012, 7, 111-120
16. Benezra, M.; Penate-Medina, O.; Zanzonico, P. B.; Schaer, D.; Ow, H.; Burns, A.; DeStanchina, E.; Longo, V.; Herz, E.; Iyer, S.; Wolchok, J.; Larson, S. M.; Wiesner, U.; Bradbury, M. S. Multimodal Silica Nanoparticles Are Effective Cancer-Targeted Probes in a Model of Human Melanoma J. Clin. Invest. 2011, 121, 2768-2780
17. Mamaeva, V.; Sahlgren, C.; Linden, M. Mesoporous Silica Nanoparticles in Medicine-Recent Advances Adv. Drug Delivery Rev. 2013, 65, 689-702
18. Tang, F.; Li, L.; Chen, D. Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery Adv. Mater. 2012, 24, 1504-1534
19. Chen, Y.; Chen, H.; Shi, J. In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles Adv. Mater. 2013, 25, 3144-3176
20. Lu, J.; Liong, M.; Zink, J. I.; Tamanoi, F. Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs Small 2007, 3, 1341-1346
21. Li, Z.; Dong, K.; Huang, S.; Ju, E.; Liu, Z.; Yin, M.; Ren, J.; Qu, X. A Smart Nanoassembly for Multistage Targeted Drug Delivery and Magnetic Resonance Imaging Adv. Funct. Mater. 2014, 24, 3612-3620
22. Yuan, L.; Tang, Q.; Yang, D.; Zhang, J. Z.; Zhang, F.; Hu, J. Preparation of pH-Responsive Mesoporous Silica Nanoparticles and Their Application in Controlled Drug Delivery J. Phys. Chem. C 2011, 115, 9926-9932
23. Fan, J.; Fang, G.; Wang, X.; Zeng, F.; Xiang, Y.; Wu, S. Targeted Anticancer Prodrug with Mesoporous Silica Nanoparticles as Vehicles Nanotechnology 2011, 22, 455102
24. Kim, J.; Kim, H. S.; Lee, N.; Kim, T.; Kim, H.; Yu, T.; Song, I. C.; Moon, W. K.; Hyeon, T. Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery Angew. Chem., Int. Ed. 2008, 47, 8438-8441
25. Yang, P.; Gai, S.; Lin, J. Functionalized Mesoporous Silica Materials for Controlled Drug Delivery Chem. Soc. Rev. 2012, 41, 3679-3698
26. Liu, Q.; Zhang, J.; Sun, W.; Xie, Q. R.; Xia, W.; Gu, H. Delivering Hydrophilic and Hydrophobic Chemotherapeutics Simultaneously by Magnetic Mesoporous Silica Nanoparticles to Inhibit Cancer Cells Int. J. Nanomed. 2012, 7, 999-1013
27. Kodera, Y.; Katanasaka, Y.; Kitamura, Y.; Tsuda, H.; Nishio, K.; Tamura, T.; Koizumi, F. Sunitinib Inhibits Lymphatic Endothelial Cell Functions and Lymph Node Metastasis in a Breast Cancer Model through Inhibition of Vascular Endothelial Growth Factor Receptor 3 Breast Cancer Res. 2011, 13, R66
28. Wood, L. Sunitinib Malate for the Treatment of Renal Cell Carcinoma Expert Opin. Pharmacother. 2012, 13, 1323-1336
29. Abouantoun, T. J.; Castellino, R. C.; MacDonald, T. J. Sunitinib Induces PTEN Expression and Inhibits PDGFR Signaling and Migration of Medulloblastoma Cells J. Neuro-Oncol. 2011, 101, 215-226
30. Nagengast, W. B.; Lub-de Hooge, M. N.; Oosting, S. F.; den Dunnen, W. F.; Warnders, F. J.; Brouwers, A. H.; de Jong, J. R.; Price, P. M.; Hollema, H.; Hospers, G. A.; Elsinga, P. H.; Hesselink, J. W.; Gietema, J. A.; de Vries, E. G. VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor During Sunitinib Treatment Cancer Res. 2011, 71, 143-153
31. Kreisl, T. N.; Smith, P.; Sul, J.; Salgado, C.; Iwamoto, F. M.; Shih, J. H.; Fine, H. A. Continuous Daily Sunitinib for Recurrent Glioblastoma J. Neuro-Oncol. 2013, 111, 41-48
32. Pan, L.; He, Q.; Liu, J.; Chen, Y.; Ma, M.; Zhang, L.; Shi, J. Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles J. Am. Chem. Soc. 2012, 134, 5722-5725
33. Hong, H.; Yang, K.; Zhang, Y.; Engle, J. W.; Feng, L.; Yang, Y.; Nayak, T. R.; Goel, S.; Bean, J.; Theuer, C. P.; Barnhart, T. E.; Liu, Z.; Cai, W. In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene ACS Nano 2012, 6, 2361-2370
34. Chen, F.; Hong, H.; Zhang, Y.; Valdovinos, H. F.; Shi, S.; Kwon, G. S.; Theuer, C. P.; Barnhart, T. E.; Cai, W. In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles ACS Nano 2013, 7, 9027-9039
35. Bass, L. A.; Wang, M.; Welch, M. J.; Anderson, C. J. In Vivo Transchelation of Copper-64 from TETA-Octreotide to Superoxide Dismutase in Rat Liver Bioconjugate Chem. 2000, 11, 527-532
36. Reardon, D. A.; Wen, P. Y.; Desjardins, A.; Batchelor, T. T.; Vredenburgh, J. J. Glioblastoma Multiforme: An Emerging Paradigm of Anti-VEGF Therapy Expert Opin. Biol. Ther. 2008, 8, 541-553
37. Chen, F.; Nayak, T. R.; Goel, S.; Valdovinos, H. F.; Hong, H.; Theuer, C. P.; Barnhart, T. E.; Cai, W. In Vivo Tumor Vasculature Targeted PET/NIRF Imaging with TRC105(Fab)-Conjugated, Dual-Labeled Mesoporous Silica Nanoparticles Mol. Pharm. 2014, 11, 4007-4014
38. Chen, K.; Li, Z. B.; Wang, H.; Cai, W.; Chen, X. Dual-Modality Optical and Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor on Tumor Vasculature Using Quantum Dots Eur. J. Nucl. Med. Mol. Imaging 2008, 35, 2235-2244
39. Hong, H.; Yang, Y.; Zhang, Y.; Engle, J. W.; Barnhart, T. E.; Nickles, R. J.; Leigh, B. R.; Cai, W. Positron Emission Tomography Imaging of CD105 Expression During Tumor Angiogenesis Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1335-1343