메뉴 건너뛰기




Volumn 7, Issue 1, 2012, Pages 111-120

Nanoparticles in targeted cancer therapy: Mesoporous silica nanoparticles entering preclinical development stage

Author keywords

biodegradation; biodistribution; cancer; in vivo; mesoporous silica nanoparticles; preclinical testing; safety; therapeutic efficacy

Indexed keywords

DOXORUBICIN; NANOPARTICLE; SILICON DIOXIDE;

EID: 84555202674     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.11.166     Document Type: Review
Times cited : (246)

References (58)
  • 1
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7, 771-782 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 2
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of rnai in humans from systemically administered sirna via targeted nanoparticles
    • Davis ME, Zuckerman JE, Choi CH et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464, 1067-1070 (2010).
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.3
  • 3
    • 74249101977 scopus 로고    scopus 로고
    • Therapeutic nanoparticles to combat cancer drug resistance
    • Hu CM, Zhang L. Therapeutic nanoparticles to combat cancer drug resistance. Curr. Drug Metab. 10, 836-841 (2009).
    • (2009) Curr. Drug Metab. , vol.10 , pp. 836-841
    • Hu, C.M.1    Zhang, L.2
  • 4
    • 34447523146 scopus 로고    scopus 로고
    • Pathotropic nanoparticles for cancer gene therapy rexin-g iv: Three-year clinical experience
    • Gordon EM, Lopez FF, Cornelio GH et al. Pathotropic nanoparticles for cancer gene therapy Rexin-G IV: three-year clinical experience. Int. J. Oncol. 29, 1053-1064 (2006).
    • (2006) Int. J. Oncol. , vol.29 , pp. 1053-1064
    • Gordon, E.M.1    Lopez, F.F.2    Cornelio, G.H.3
  • 5
    • 78650348824 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic studies of cyt-6091, a novel pegylated colloidal gold-rhtnf nanomedicine
    • Libutti SK, Paciotti GF, Byrnes AA et al. Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin. Cancer Res. 16, 6139-6149 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6139-6149
    • Libutti, S.K.1    Paciotti, G.F.2    Byrnes, A.A.3
  • 6
    • 79551652066 scopus 로고    scopus 로고
    • Current major cancer targets for nanoparticle systems
    • Wesselinova D. Current major cancer targets for nanoparticle systems. Curr. Cancer Drug Targets 11, 164-183 (2011).
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 164-183
    • Wesselinova, D.1
  • 8
    • 79551631275 scopus 로고    scopus 로고
    • Advances in nano drugs for cancer chemotherapy
    • Ali I, Rahis-Uddin, Salim K et al. Advances in nano drugs for cancer chemotherapy. Curr. Cancer Drug Targets 11, 135-146 (2011).
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 135-146
    • Ali, I.1    Rahis-Uddin Salim, K.2
  • 9
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7, 771-782 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 11
    • 79960027556 scopus 로고    scopus 로고
    • Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
    • Benezra M, Penate-Medina O, Zanzonico PB et al. Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. J. Clin. Invest. 121(7), 2768-2780 (2011).
    • (2011) J. Clin. Invest. , vol.121 , Issue.7 , pp. 2768-2780
    • Benezra, M.1    Penate-Medina, O.2    Zanzonico, P.B.3
  • 12
    • 77955492012 scopus 로고    scopus 로고
    • Models of structure, dynamics and reactivity of bioglasses: A review
    • Tilocca A. Models of structure, dynamics and reactivity of bioglasses: a review. J. Mater. Chem. 20, 6848-6858 (2010).
    • (2010) J. Mater. Chem. , vol.20 , pp. 6848-6858
    • Tilocca, A.1
  • 16
    • 77957893294 scopus 로고    scopus 로고
    • Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-Opportunities and challenges
    • Rosenholm JM, Sahlgren C, Lindén M. Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles- opportunities and challenges. Nanoscale 2, 1870-1883 (2010).
    • (2010) Nanoscale , vol.2 , pp. 1870-1883
    • Rosenholm, J.M.1    Sahlgren, C.2    Lindén, M.3
  • 17
    • 79955581524 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticle based nano drug delivery systems: Synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
    • He QJ, Shi JL. Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility. J. Mater. Chem. 21, 5845-5855 (2011)
    • (2011) J. Mater. Chem. , vol.21 , pp. 5845-5855
    • He, Q.J.1    Shi, J.L.2
  • 18
    • 77956945642 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles for intracellular controlled drug delivery
    • Vivero-Escoto JL, Slowing II, Trewyn BG et al. Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small 6, 1952-1967 (2010).
    • (2010) Small , vol.6 , pp. 1952-1967
    • Vivero-Escoto, J.L.1    Slowing, I.I.2    Trewyn, B.G.3
  • 19
    • 79955439262 scopus 로고    scopus 로고
    • Mesoporous materials as controlled drug delivery formulations
    • Santos, HA; Salonen, J; Bimbo, LM et al. Mesoporous materials as controlled drug delivery formulations. J. Drug Delivery Sci. Tech. 21, 139-155 (2011).
    • (2011) J. Drug Delivery Sci. Tech. , vol.21 , pp. 139-155
    • Santos, H.A.1    Salonen, J.2    Bimbo, L.M.3
  • 20
    • 41549142680 scopus 로고    scopus 로고
    • Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica
    • Mellaerts R, Mols R, Jammaer JAG et al. Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica. Eur. J. Pharm. Biopharm. 69, 223-230 (2008).
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 223-230
    • Mellaerts, R.1    Mols, R.2    Jammaer, J.A.G.3
  • 21
    • 53549125837 scopus 로고    scopus 로고
    • Bone-regenerative bioceramic implants with drug and protein controlled delivery capability
    • Vallet-Regi M, Balas F, Colilla M et al. Bone-regenerative bioceramic implants with drug and protein controlled delivery capability. Progr. Solid State Chem. 36, 163-191 (2008).
    • (2008) Progr. Solid State Chem. , vol.36 , pp. 163-191
    • Vallet-Regi, M.1    Balas, F.2    Colilla, M.3
  • 22
    • 68549134917 scopus 로고    scopus 로고
    • Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control
    • Dai C, Yuan Y, Liu C et al. Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control. Biomaterials 30, 5364-5374 (2009).
    • (2009) Biomaterials , vol.30 , pp. 5364-5374
    • Dai, C.1    Yuan, Y.2    Liu, C.3
  • 23
    • 33748690830 scopus 로고    scopus 로고
    • 2 solids for the treatment of temporal lobe epilepsy
    • DOI 10.1016/j.optmat.2006.03.017, PII S0925346706001157, Selected Papers fron the Second Tropical Meeting on the Nanostructured Materials and Nonotechnology NANOTECH-2005
    • López T, Basaldella EI, Ojeda MJ et al. Encapsulation of valproic acid and sodic phenytoin in ordered mesoporous SiO solids for the treatment of temporal lope epilepsy. Optical Mater. 29, 75-81 (2006). (Pubitemid 44389906)
    • (2006) Optical Materials , vol.29 , Issue.1 , pp. 75-81
    • Lopez, T.1    Basaldella, E.I.2    Ojeda, M.L.3    Manjarrez, J.4    Alexander-Katz, R.5
  • 24
    • 38149038610 scopus 로고    scopus 로고
    • Multifunctional mesoporous silica nanoparticles for intracellular labeling and animal magnetic resonance imaging studies
    • Wu SH, Lin YS, Hung Y et al. Multifunctional mesoporous silica nanoparticles for intracellular labeling and animal magnetic resonance imaging studies. Chem. Bio. Chem. 9, 53-57 (2008).
    • (2008) Chem. Bio. Chem. , vol.9 , pp. 53-57
    • Wu, S.H.1    Lin, Y.S.2    Hung, Y.3
  • 26
    • 44949136246 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles improve magnetic labeling effciency in human stem cells
    • Liu HM, Wu SH, Lu CW et al. Mesoporous silica nanoparticles improve magnetic labeling effciency in human stem cells. Small 4, 619-626 (2008).
    • (2008) Small , vol.4 , pp. 619-626
    • Liu, H.M.1    Wu, S.H.2    Lu, C.W.3
  • 27
    • 33846892018 scopus 로고    scopus 로고
    • Bifunctional magnetic silica nanoparticles for highly effcient human stem cell labeling
    • Lu CW, Hung Y, Hsiao JK et al. Bifunctional magnetic silica nanoparticles for highly effcient human stem cell labeling. Nano Lett. 7, 149 (2007).
    • (2007) Nano Lett , vol.7 , pp. 149
    • Lu, C.W.1    Hung, Y.2    Hsiao, J.K.3
  • 28
    • 52649172803 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking
    • Hsiao JK, Tsai CP, Chung TH et al. Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking. Small 4, 1445-1452, (2008).
    • (2008) Small , vol.4 , pp. 1445-1452
    • Hsiao, J.K.1    Tsai, C.P.2    Chung, T.H.3
  • 29
    • 78649974584 scopus 로고    scopus 로고
    • Gd-labeled microparticles in mri: In vivo imaging of microparticles after intraperitoneal injection
    • Steinbacher JL, Lathrop SA, Cheng K et al. Gd-labeled microparticles in MRI: in vivo imaging of microparticles after intraperitoneal injection. Small 6, 2678-2682 (2010).
    • (2010) Small , vol.6 , pp. 2678-2682
    • Steinbacher, J.L.1    Lathrop, S.A.2    Cheng, K.3
  • 31
    • 58949102416 scopus 로고    scopus 로고
    • Near-infrared mesoporous silica nanoparticles for optical imaging: Characterization and in vivo biodistribution
    • Lee CH, Cheng SH, Wang YJ et al. Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv. Funct. Mater. 19, 215-222 (2009).
    • (2009) Adv. Funct. Mater. , vol.19 , pp. 215-222
    • Lee, C.H.1    Cheng, S.H.2    Wang, Y.J.3
  • 32
    • 78651342869 scopus 로고    scopus 로고
    • In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: Effects of particle size and pegylation
    • He Q, Zhang Z, Gao F et al. In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation. Small 7, 271-280 (2011).
    • (2011) Small , vol.7 , pp. 271-280
    • He, Q.1    Zhang, Z.2    Gao, F.3
  • 33
    • 79961071789 scopus 로고    scopus 로고
    • The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo
    • Huang X, Li L, Liu T et al. The shape effect of Mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano 5(7), 5390-5399 (2011).
    • (2011) ACS Nano , vol.5 , Issue.7 , pp. 5390-5399
    • Huang, X.1    Li, L.2    Liu, T.3
  • 34
    • 54249135767 scopus 로고    scopus 로고
    • Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fuorescence imaging and for drug delivery
    • Kim J, Kim HS, Lee N et al. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fuorescence imaging and for drug delivery Angew. Chem. Int. Ed. 47, 8438-8441 (2008).
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 8438-8441
    • Kim, J.1    Kim, H.S.2    Lee, N.3
  • 35
    • 74949092822 scopus 로고    scopus 로고
    • Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fuorescence imaging, and drug delivery
    • Lee JE, Lee N, Kim H et al. Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fuorescence imaging, and drug delivery. J. Am. Chem. Soc. 132, 552-557 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 552-557
    • Lee, J.E.1    Lee, N.2    Kim, H.3
  • 36
    • 77955613395 scopus 로고    scopus 로고
    • Biocompatibility, biodistribution, and drug-delivery effciency of mesoporous silica nanoparticles for cancer therapy in animals
    • Lu J, Liong M, Li Z et al. Biocompatibility, biodistribution, and drug-delivery effciency of mesoporous silica nanoparticles for cancer therapy in animals. Small 6, 1794-1805 (2010).
    • (2010) Small , vol.6 , pp. 1794-1805
    • Lu, J.1    Liong, M.2    Li, Z.3
  • 37
    • 80051516651 scopus 로고    scopus 로고
    • Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
    • Meng H, Xue M, Xia T et al. Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano 5, 4131-4144 (2011).
    • (2011) ACS Nano , vol.5 , pp. 4131-4144
    • Meng, H.1    Xue, M.2    Xia, T.3
  • 38
    • 79961032358 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of notch signaling in cancer
    • Mamaeva V, Rosenholm JM, Bate-Eya LT et al. Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of notch signaling in cancer. Mol. Ther. 19, 1538-1546 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1538-1546
    • Mamaeva, V.1    Rosenholm, J.M.2    Bate-Eya, L.T.3
  • 39
    • 84855851289 scopus 로고    scopus 로고
    • Vivo tumor suppression effcacy of mesoporous silica nanoparticles-based drug delivery system enhanced effcacy by folate modification
    • doi:10.1016/j. nano.2011.06.002 (Epub ahead of print)
    • Lu J, Li Z, Zink JI, Tamanoi F. In vivo tumor suppression effcacy of mesoporous silica nanoparticles-based drug delivery system: enhanced effcacy by folate modifcation. Nanomed. Nanotech. Biol. Med. doi:10.1016/j. nano.2011.06.002 (2011) (Epub ahead of print).
    • (2011) Nanomed.Nanotech.Biol.Med
    • Lu, J.1    Li, Z.2    Zink, J.I.3    Tamanoi, F.4
  • 40
    • 0037408412 scopus 로고    scopus 로고
    • Analytical investigation of the chemical reactivity and stability of aminopropyl-grafted silica in aqueous medium
    • Etienne M, Walcarius A. Analytical investigation of the chemical reactivity and stability of aminopropyl-grafted silica in aqueous medium. Talanta 59, 1173-1188 (2003).
    • (2003) Talanta , vol.59 , pp. 1173-1188
    • Etienne, M.1    Walcarius, A.2
  • 41
    • 77950340684 scopus 로고    scopus 로고
    • Bio-degradation study of colloidal mesoporous silica nanoparticles: Effect of surface functionalization with organo-silanes and poly(ethylene glycol)
    • Cauda V, Schlossbauer A, Bein T. Bio-degradation study of colloidal mesoporous silica nanoparticles: effect of surface functionalization with organo-silanes and poly(ethylene glycol). Microporous Mesoporous Mater. 132, 60-71 (2010).
    • (2010) Microporous Mesoporous Mater , vol.132 , pp. 60-71
    • Cauda, V.1    Schlossbauer, A.2    Bein, T.3
  • 42
    • 72049121849 scopus 로고    scopus 로고
    • Pore occlusion in mcm-41 spheres immersed in SBF and the effect on ibuprofen delivery kinetics: A quantitative model
    • Mortera R, Fiorilli S, Garrone E et al. Pore occlusion in MCM-41 spheres immersed in SBF and the effect on ibuprofen delivery kinetics: a quantitative model. Chem. Eng. J. 156, 184-192 (2010).
    • (2010) Chem. Eng. J. , vol.156 , pp. 184-192
    • Mortera, R.1    Fiorilli, S.2    Garrone, E.3
  • 43
    • 34248382535 scopus 로고    scopus 로고
    • The chemistry of silica and its potential health benefts
    • Martin KR. The chemistry of silica and its potential health benefts. J. Nutr. Health Aging 11, 94-97 (2007).
    • (2007) J. Nutr. Health Aging , vol.11 , pp. 94-97
    • Martin, K.R.1
  • 44
    • 77953020259 scopus 로고    scopus 로고
    • Surface charge-mediated rapid hepatobiliary exretion of mesoporous silica nanoparticles
    • Souris JS, Lee CH, Cheng SH et al. Surface charge-mediated rapid hepatobiliary exretion of mesoporous silica nanoparticles. Biomaterials 31, 5564-5574 (2010).
    • (2010) Biomaterials , vol.31 , pp. 5564-5574
    • Souris, J.S.1    Lee, C.H.2    Cheng, S.H.3
  • 45
    • 78649978573 scopus 로고    scopus 로고
    • Increased effcacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy
    • Hillegass JM, Blumen SR, Cheng K et al. Increased effcacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy. Int. J. Cancer. 129, 233-244 (2011).
    • (2011) Int. J. Cancer. , vol.129 , pp. 233-244
    • Hillegass, J.M.1    Blumen, S.R.2    Cheng, K.3
  • 46
    • 79954624195 scopus 로고    scopus 로고
    • Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy
    • Wang T, Chai F, Q. Fu et al. Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy, J. Mater. Chem. 21, 5299-5306 (2011).
    • (2011) J. Mater. Chem. , vol.21 , pp. 5299-5306
    • Wang, T.1    Chai, F.2    Fu, Q.3
  • 47
    • 79956028537 scopus 로고    scopus 로고
    • Enhanced chemotherapy of cancer using ph-sensitive mesoporous silica nanoparticles to antagonize p-glycoprotein-mediated drug resistance
    • Huang IP, Sun SP, Cheng SH et al. Enhanced chemotherapy of cancer using pH-sensitive mesoporous silica nanoparticles to antagonize P-glycoprotein- mediated drug resistance. Mol. Cancer Ther. 10, 761-769 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 761-769
    • Huang, I.P.1    Sun, S.P.2    Cheng, S.H.3
  • 48
    • 80053578495 scopus 로고    scopus 로고
    • The comparative effects of mesoporous silica nanoparticles and colloidal silica on infammation and apoptosis
    • Lee S, Yun H-S, Kim S-H. The comparative effects of mesoporous silica nanoparticles and colloidal silica on infammation and apoptosis. Biomaterials 32(35), 9434-9443 (2011).
    • (2011) Biomaterials , vol.32 , Issue.35 , pp. 9434-9443
    • Lee, S.1    Yun, H.-S.2    Kim, S.-H.3
  • 49
    • 69849110521 scopus 로고    scopus 로고
    • Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity
    • Lin YS, Haynes CL. Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity. Chem. Mater. 21, 3979-3986 (2009).
    • (2009) Chem. Mater. , vol.21 , pp. 3979-3986
    • Lin, Y.S.1    Haynes, C.L.2
  • 50
    • 58149465609 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells
    • Slowing II, Wu CW, Vivero-Escoto JL et al. Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells. Small 5, 57-62 (2009).
    • (2009) Small , vol.5 , pp. 57-62
    • Slowing, I.I.1    Wu, C.W.2    Vivero-Escoto, J.L.3
  • 51
    • 79951890716 scopus 로고    scopus 로고
    • Interaction of mesoporous silica nanoparticles with human red blood cell membranes: Size and surface effects
    • Zhao Y, Sun X, Zhang G et al. Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects. ACS Nano 5, 1366-1375 (2011).
    • (2011) ACS Nano , vol.5 , pp. 1366-1375
    • Zhao, Y.1    Sun, X.2    Zhang, G.3
  • 52
    • 49649100580 scopus 로고    scopus 로고
    • The biocompatibility of mesoporous silicates
    • Hudson SP, Padera RF, Langer R et al. The biocompatibility of mesoporous silicates. Biomaterials 29, 4045-4055 (2008).
    • (2008) Biomaterials , vol.29 , pp. 4045-4055
    • Hudson, S.P.1    Padera, R.F.2    Langer, R.3
  • 53
    • 77953649363 scopus 로고    scopus 로고
    • The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species
    • Huang X, Zhuang J, Teng X et al. The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species. Biomaterials 31, 6142-6153 (2010).
    • (2010) Biomaterials , vol.31 , pp. 6142-6153
    • Huang, X.1    Zhuang, J.2    Teng, X.3
  • 54
    • 78650266662 scopus 로고    scopus 로고
    • Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice
    • Liu T, Li L, Teng X et al. Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice. Biomaterials 32, 1657-1668 (2011).
    • (2011) Biomaterials , vol.32 , pp. 1657-1668
    • Liu, T.1    Li, L.2    Teng, X.3
  • 55
    • 46749085146 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles inhibit cellular respiration
    • Tao Z, Morrow MP, Asefa T et al. Mesoporous silica nanoparticles inhibit cellular respiration. Nano Lett. 8, 1517-1526 (2008).
    • (2008) Nano Lett , vol.8 , pp. 1517-1526
    • Tao, Z.1    Morrow, M.P.2    Asefa, T.3
  • 56
    • 78649306253 scopus 로고    scopus 로고
    • Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues
    • Al Shamsi M, Al Samri MT, Al-Salam S et al. Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues. Chem. Res. Toxicol. 23, 1796-1805 (2010).
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 1796-1805
    • Al Shamsi, M.1    Al Samri, M.T.2    Al-Salam, S.3
  • 57
    • 77953649363 scopus 로고    scopus 로고
    • The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species
    • Huang X, Zhuang J, Teng X et al. The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species Biomaterials 31, 6142-6153 (2010).
    • (2010) Biomaterials , vol.31 , pp. 6142-6153
    • Huang, X.1    Zhuang, J.2    Teng, X.3
  • 58
    • 80052201700 scopus 로고    scopus 로고
    • Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray and NIR fuorescence imaging
    • Luo T, Huang P, Gao G et al. Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray and NIR fuorescence imaging. Optics Express 19, 17030-17039 (2011).
    • (2011) Optics Express , vol.19 , pp. 17030-17039
    • Luo, T.1    Huang, P.2    Gao, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.