In vivo tumor vasculature targeted PET/NIRF Imaging with TRC105(Fab)-conjugated, dual-labeled mesoporous silica nanoparticles

Molecular Pharmaceutics

Volumn 11, Issue 11, 2014, Pages 4007-4014

  Chen, Feng ^a   Nayak, Tapas R ^a   Goel, Shreya ^b   Valdovinos, Hector F ^c   Hong, Hao ^a,d   Theuer, Charles P ^a   Barnhart, Todd E ^c   Cai, Weibo ^a,b,c,e  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Wisconsin Madison   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d TRACON Pharmaceuticals Inc   (United States)

^e UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Mesoporous silica nanoparticle (MSN); Near infrared fluorescence (NIRF) imaging; Positron emission tomography (PET) imaging; Vasculature targeting

Indexed keywords

CAROTUXIMAB; MESOPOROUS SILICA NANOPARTICLE; MESOPOROUS SILICA NANOPARTICLE 800 CW TRC 105; MESOPOROUS SILICA NANOPARTICLE 800 CW TRC 105 CU 64; TRACER; UNCLASSIFIED DRUG; COPPER; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; NANOPARTICLE; RADIOPHARMACEUTICAL AGENT; SILICON DIOXIDE; TRC105;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TISSUE LEVEL; EX VIVO STUDY; FEMALE; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TUMOR VASCULARIZATION; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; EXPERIMENTAL MAMMARY NEOPLASM; FLUORESCENCE; IMMUNOLOGY; METABOLISM; MULTIMODAL IMAGING; NEAR INFRARED SPECTROSCOPY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROCEDURES; SCINTISCANNING; TISSUE DISTRIBUTION; TUMOR CELL CULTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; COPPER RADIOISOTOPES; FEMALE; FLUORESCENCE; IMMUNOGLOBULIN G; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MULTIMODAL IMAGING; NANOPARTICLES; NEOVASCULARIZATION, PATHOLOGIC; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SILICON DIOXIDE; SPECTROSCOPY, NEAR-INFRARED; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 84965191272     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500306k     Document Type: Article

References (31)

1. Chen, F.; Cai, W. Tumor Vasculature Targeting: A Generally Applicable Approach for Functionalized Nanomaterials. Small 2014, 10, 1887-1893.
2. Cai, W.; Shin, D. W.; Chen, K.; Gheysens, O.; Cao, Q.; Wang, S. X.; Gambhir, S. S.; Chen, X. Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects. Nano Lett. 2006, 6, 669-676.
3. Liu, Z.; Cai, W.; He, L.; Nakayama, N; Chen, K.; Sun, X.; Chen, X.; Dai, H. In Vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice. Nature Nanotechnol. 2007, 2, 47-52.
4. Hong, H; Yang, K.; Zhang, Y.; Engle, J. W.; Feng, L.; Yang, Y.; Nayak, T. R.; Goel, S.; Bean, J.; Theuer, C. P.; Barnhart, T.E.; Liu, Z.; Cai, W. In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene. ACS Nano 2012, 6, 2361-2370.
5. Shi, S.; Yang, K.; Hong, H.; Valdovinos, H. F.; Nayak, T. R.; Zhang, Y.; Theuer, C. P.; Barnhart, T. E.; Liu, Z.; Cai, W. Tumor Vasculature Targeting and Imaging in Living Mice with Reduced Graphene Oxide. Biomaterials 2013, 34, 3002-3009.
6. Rosen, L. S.; Hurwitz, H. I.; Wong, M. K.; Goldman, J.; Mendelson, D. S.; Figg, W. D.; Spencer, S.; Adams, B. J.; Alvarez, D.; Seon, B. K.; Theuer, C. P.; Leigh, B. R.; Gordon, M. S. A Phase I Firstin-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer. Clin. Cancer Res. 2012, 18, 4820-9.
7. Seon, B. K.; Haba, A.; Matsuno, F.; Takahashi, N.; Tsujie, M.; She, X.; Harada, N.; Uneda, S.; Tsujie, T.; Toi, H.; Tsai, H.; Haruta, Y. Endoglin-Targeted Cancer Therapy. Curr. Drug Delivery 2011, 8, 135-143.
8. Fonsatti, E.; Nicolay, H. J.; Altomonte, M.; Covre, A.; Maio, M. Targeting Cancer Vasculature Via Endoglin/CD105: A Novel Antibody-Based Diagnostic and Therapeutic Strategy in Solid Tumours. Cardiovasc. Res. 2010, 86, 12-19.
9. Hong, H.; Yang, Y.; Zhang, Y.; Engle, J. W.; Barnhart, T. E.; Nickles, R. J.; Leigh, B. R.; Cai, W. Positron Emission Tomography Imaging of CD105 Expression During Tumor Angiogenesis. Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 1335-1343.
10. Hong, H.; Zhang, Y.; Orbay, H.; Valdovinos, H. F.; Nayak, T. R.; Bean, J.; Theuer, C. P.; Barnhart, T. E.; Cai, W. Positron Emission Tomography Imaging of Tumor Angiogenesis with a (61/64)Cu-Labeled F(ab')(2) Antibody Fragment. Mol. Pharm. 2013, 10, 709-716.
11. James, M. L.; Gambhir, S. S. A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications. Physiol. Rev. 2012, 92, 897-965.
12. Gambhir, S. S. Molecular Imaging of Cancer with Positron Emission Tomography. Nature Rev. Cancer 2002, 2, 683-693.
13. Cai, W.; Chen, K.; Li, Z. B.; Gambhir, S. S.; Chen, X. Dual-Function Probe for PET and Near-Infrared Fluorescence Imaging of Tumor Vasculature. J. Nucl. Med. 2007, 48, 1862-1870.
14. Chen, K.; Li, Z. B.; Wang, H.; Cai, W.; Chen, X. Dual-Modality Optical and Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor on Tumor Vasculature Using Quantum Dots. Eur. J. Nucl. Med. Mol. Imaging 2008, 35, 2235-2244.
15. 3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis. J. Nucl. Med. 2013, 54, 96-103.
16. Sun, Y.; Yu, M.; Liang, S.; Zhang, Y.; Li, C.; Mou, T.; Yang, W.; Zhang, X.; Li, B.; Huang, C.; Li, F. Fluorine-18 Labeled Rare-Earth Nanoparticles for Positron Emission Tomography (PET) Imaging of Sentinel Lymph Node. Biomaterials 2011, 32, 2999-3007.
17. Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J.; Gao, J.; Li, X.; Chen, X. PET/NIRF/MRI Triple Functional Iron Oxide Nano-particles. Biomaterials 2010, 31, 3016-3022.
18. 4 Nanophosphors for Multimodality PET/MR/UCL Imaging. Biomaterials 2011, 32, 1148-1156.
19. Huang, X.; Zhang, F.; Lee, S.; Swierczewska, M.; Kiesewetter, D. O.; Lang, L.; Zhang, G.; Zhu, L.; Gao, H.; Choi, H. S.; Niu, G.; Chen, X. Long-Term Multimodal Imaging of Tumor Draining Sentinel Lymph Nodes Using Mesoporous Silica-Based Nanoprobes. Biomaterials 2012, 33, 4370-4378.
20. Zhang, Y.; Hong, H.; Engle, J. W.; Yang, Y.; Barnhart, T. E.; Cai, W. Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Vascular Endothelial Growth Factor with Dual-Labeled Bevacizumab. Am. J. Nucl. Med. Mol. Imaging 2012, 2, 1-13.
21. Vallet-Regi, M.; Ramila, A.; del Real, R. P.; Perez-Pariente, J. A New Property of Mcm-41: Drug Delivery System. Chem. Mater. 2000, 13, 308-311.
22. Lu, J.; Liong, M.; Li, Z.; Zink, J. I.; Tamanoi, F. Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals. Small 2010, 6, 1794-1805.
23. Meng, H.; Xue, M.; Xia, T.; Ji, Z.; Tarn, D. Y.; Zink, J. I.; Nel, A. E. Use of Size and a Copolymer Design Feature to Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model. ACS Nano 2011, 5, 4131-4144.
24. Pan, L.; He, Q.; Liu, J.; Chen, Y.; Ma, M.; Zhang, L.; Shi, J. Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles. J. Am. Chem. Soc. 2012, 134, 5722-5725.
25. Wang, K.; He, X.; Yang, X.; Shi, H. Functionalized Silica Nanoparticles: A Platform for Fluorescence Imaging at the Cell and Small Animal Levels. Acc. Chem. Res. 2013, 46, 1367-1376.
26. Lee, C. H.; Cheng, S. H.; Wang, Y. J.; Chen, Y. C.; Chen, N. T.; Souris, J.; Chen, C. T.; Mou, C. Y.; Yang, C. S.; Lo, L. W. Near-Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and in Vivo Biodistribution. Adv. Funct. Mater. 2009, 19, 215-222.
27. Pan, J.; Wan, D.; Gong, J. Pegylated Liposome Coated QDs/Mesoporous Silica Core-Shell Nanoparticles for Molecular Imaging. Chem. Commun. 2011, 47, 3442-3444.
28. Liu, J.; Bu, W.; Zhang, S.; Chen, F.; Xing, H.; Pan, L.; Zhou, L.; Peng, W.; Shi, J. Controlled Synthesis of Uniform and Monodisperse Upconversion Core/Mesoporous Silica Shell Nanocomposites for Bimodal Imaging. Chemistry 2012, 18, 2335-2341.
29. Zhang, Y.; Hong, H.; Orbay, H.; Valdovinos, H. F.; Nayak, T. R.; Theuer, C. P.; Barnhart, T. E.; Cai, W. Pet Imaging of CD105/Endoglin Expression with a (6)(1)/(6)(4)Cu-Labeled Fab Antibody Fragment. Eur. J. Nucl. Med. Mol. Imaging 2013, 40, 759-767.
30. Chen, F.; Hong, H.; Zhang, Y.; Valdovinos, H. F.; Shi, S.; Kwon, G. S.; Theuer, C. P.; Barnhart, T. E.; Cai, W. In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles. ACS Nano 2013, 7, 9027-9039.
31. Orbay, H.; Zhang, Y.; Valdovinos, H. F.; Song, G.; Hernandez, R.; Theuer, C. P.; Hacker, T. A.; Nickles, R. J.; Cai, W. Positron Emission Tomography Imaging of CD105 Expression in a Rat Myocardial Infarction Model with (64)Cu-Nota-TRC105. Am. J. Nucl. Med. Mol. Imaging 2013, 4, 1-9.