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Volumn 13, Issue 3, 2011, Pages

Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MONOCLONAL ANTIBODY DC101; SUNITINIB; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; ANGIOGENESIS INHIBITOR; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; VASCULOTROPIN C; VASCULOTROPIN D;

EID: 79959278619     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2903     Document Type: Article
Times cited : (91)

References (34)
  • 1
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: building a framework
    • 10.1016/j.cell.2006.11.001, 17110329
    • Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006, 127:679-695. 10.1016/j.cell.2006.11.001, 17110329.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 3
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • 10.1038/nature04480, 16355212
    • Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005, 438:946-953. 10.1038/nature04480, 16355212.
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 4
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • 10.1038/nrc2618, 19279573
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009, 9:239-252. 10.1038/nrc2618, 19279573.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 5
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: molecular mechanisms and future promise
    • 10.1016/j.cell.2010.01.045, 20178740, 20178740
    • Tammela T, Alitalo K. Lymphangiogenesis: molecular mechanisms and future promise. Cell 2010, 140:460-476. 10.1016/j.cell.2010.01.045, 20178740, 20178740.
    • (2010) Cell , vol.140 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 6
    • 13844265843 scopus 로고    scopus 로고
    • Focus on lymphangiogenesis in tumor metastasis
    • 10.1016/j.ccr.2005.01.017, 15710325
    • Achen MG, McColl BK, Stacker SA. Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 2005, 7:121-127. 10.1016/j.ccr.2005.01.017, 15710325.
    • (2005) Cancer Cell , vol.7 , pp. 121-127
    • Achen, M.G.1    McColl, B.K.2    Stacker, S.A.3
  • 7
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • 10.1038/nrm2183, 17522591
    • Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007, 8:464-478. 10.1038/nrm2183, 17522591.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 8
    • 35748957169 scopus 로고    scopus 로고
    • Potential therapeutic strategies for lymphatic metastasis
    • 10.1016/j.mvr.2007.08.006, 2525453, 17950368
    • Zwaans BM, Bielenberg DR. Potential therapeutic strategies for lymphatic metastasis. Microvasc Res 2007, 74:145-158. 10.1016/j.mvr.2007.08.006, 2525453, 17950368.
    • (2007) Microvasc Res , vol.74 , pp. 145-158
    • Zwaans, B.M.1    Bielenberg, D.R.2
  • 11
    • 4243325849 scopus 로고    scopus 로고
    • Molecular characterization of lymphatic endothelial cells
    • 10.1073/pnas.242401399, 138566, 12446836
    • Podgrabinska S, Braun P, Velasco P, Kloos B, Pepper MS, Skobe M. Molecular characterization of lymphatic endothelial cells. Proc Natl Acad Sci USA 2002, 99:16069-16074. 10.1073/pnas.242401399, 138566, 12446836.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16069-16074
    • Podgrabinska, S.1    Braun, P.2    Velasco, P.3    Kloos, B.4    Pepper, M.S.5    Skobe, M.6
  • 12
    • 33750345654 scopus 로고    scopus 로고
    • Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis
    • 10.1158/0008-5472.CAN-06-1488, 17018613
    • Zeng Y, Opeskin K, Goad J, Williams ED. Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis. Cancer Res 2006, 66:9566-9575. 10.1158/0008-5472.CAN-06-1488, 17018613.
    • (2006) Cancer Res , vol.66 , pp. 9566-9575
    • Zeng, Y.1    Opeskin, K.2    Goad, J.3    Williams, E.D.4
  • 13
    • 33845727079 scopus 로고    scopus 로고
    • Pathways targeting tumor lymphangiogenesis
    • 10.1158/1078-0432.CCR-06-1800, 17145802
    • Wissmann C, Detmar M. Pathways targeting tumor lymphangiogenesis. Clin Cancer Res 2006, 12:6865-6868. 10.1158/1078-0432.CCR-06-1800, 17145802.
    • (2006) Clin Cancer Res , vol.12 , pp. 6865-6868
    • Wissmann, C.1    Detmar, M.2
  • 16
    • 0035903330 scopus 로고    scopus 로고
    • Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    • 10.1084/jem.194.6.797, 2195953, 11560995
    • Kriehuber E, Breiteneder-Geleff S, Groeger M, Soleiman A, Schoppmann SF, Stingl G, Kerjaschki D, Maurer D. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med 2001, 194:797-808. 10.1084/jem.194.6.797, 2195953, 11560995.
    • (2001) J Exp Med , vol.194 , pp. 797-808
    • Kriehuber, E.1    Breiteneder-Geleff, S.2    Groeger, M.3    Soleiman, A.4    Schoppmann, S.F.5    Stingl, G.6    Kerjaschki, D.7    Maurer, D.8
  • 19
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002, 94:819-825.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3    Koshikawa, K.4    Yla-Herttuala, S.5    Takahashi, T.6    Alitalo, K.7
  • 20
    • 33645046619 scopus 로고    scopus 로고
    • Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2
    • 10.1158/0008-5472.CAN-05-1843, 16510584
    • Roberts N, Kloos B, Cassella M, Podgrabinska S, Persaud K, Wu Y, Pytowski B, Skobe M. Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res 2006, 66:2650-2657. 10.1158/0008-5472.CAN-05-1843, 16510584.
    • (2006) Cancer Res , vol.66 , pp. 2650-2657
    • Roberts, N.1    Kloos, B.2    Cassella, M.3    Podgrabinska, S.4    Persaud, K.5    Wu, Y.6    Pytowski, B.7    Skobe, M.8
  • 21
    • 54249140119 scopus 로고    scopus 로고
    • Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis
    • 10.1158/0008-5472.CAN-08-1488, 2800077, 18829538
    • Burton JB, Priceman SJ, Sung JL, Brakenhielm E, An DS, Pytowski B, Alitalo K, Wu L. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res 2008, 68:7828-7837. 10.1158/0008-5472.CAN-08-1488, 2800077, 18829538.
    • (2008) Cancer Res , vol.68 , pp. 7828-7837
    • Burton, J.B.1    Priceman, S.J.2    Sung, J.L.3    Brakenhielm, E.4    An, D.S.5    Pytowski, B.6    Alitalo, K.7    Wu, L.8
  • 22
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase
    • 10.1158/1078-0432.CCR-07-5270, 18765537
    • Matsui J, Funahashi Y, Uenaka T, Watanabe T, Tsuruoka A, Asada M. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 2008, 14:5459-5465. 10.1158/1078-0432.CCR-07-5270, 18765537.
    • (2008) Clin Cancer Res , vol.14 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3    Watanabe, T.4    Tsuruoka, A.5    Asada, M.6
  • 23
    • 49649083397 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
    • 10.1158/0008-5472.CAN-07-5809, 18559522
    • Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res 2008, 68:4754-4762. 10.1158/0008-5472.CAN-07-5809, 18559522.
    • (2008) Cancer Res , vol.68 , pp. 4754-4762
    • Heckman, C.A.1    Holopainen, T.2    Wirzenius, M.3    Keskitalo, S.4    Jeltsch, M.5    Yla-Herttuala, S.6    Wedge, S.R.7    Jurgensmeier, J.M.8    Alitalo, K.9
  • 24
    • 58149521991 scopus 로고    scopus 로고
    • Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis
    • 10.1158/1535-7163.MCT-08-0679, 19139113
    • Schomber T, Zumsteg A, Strittmatter K, Crnic I, Antoniadis H, Littlewood-Evans A, Wood J, Christofori G. Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis. Mol Cancer Ther 2009, 8:55-63. 10.1158/1535-7163.MCT-08-0679, 19139113.
    • (2009) Mol Cancer Ther , vol.8 , pp. 55-63
    • Schomber, T.1    Zumsteg, A.2    Strittmatter, K.3    Crnic, I.4    Antoniadis, H.5    Littlewood-Evans, A.6    Wood, J.7    Christofori, G.8
  • 25
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • 10.1038/nrd2380, 17690708
    • Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007, 6:734-745. 10.1038/nrd2380, 17690708.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 26
    • 33644800080 scopus 로고    scopus 로고
    • Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice
    • 10.1186/bcr1026, 1175057, 15987449
    • Jenkins DE, Hornig YS, Oei Y, Dusich J, Purchio T. Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 2005, 7:R444-454. 10.1186/bcr1026, 1175057, 15987449.
    • (2005) Breast Cancer Res , vol.7
    • Jenkins, D.E.1    Hornig, Y.S.2    Oei, Y.3    Dusich, J.4    Purchio, T.5
  • 27
    • 54949135243 scopus 로고    scopus 로고
    • Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III
    • Fukai J, Nishio K, Itakura T, Koizumi F. Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III. Cancer Sci 2008, 99:2062-2069.
    • (2008) Cancer Sci , vol.99 , pp. 2062-2069
    • Fukai, J.1    Nishio, K.2    Itakura, T.3    Koizumi, F.4
  • 28
    • 17044458971 scopus 로고    scopus 로고
    • Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
    • 10.1074/jbc.M304499200, 12881528
    • Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 2003, 278:40973-40979. 10.1074/jbc.M304499200, 12881528.
    • (2003) J Biol Chem , vol.278 , pp. 40973-40979
    • Dixelius, J.1    Makinen, T.2    Wirzenius, M.3    Karkkainen, M.J.4    Wernstedt, C.5    Alitalo, K.6    Claesson-Welsh, L.7
  • 30
    • 70349495869 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines
    • 10.1158/1535-7163.MCT-09-0380, 2819052, 19755510
    • Morelli MP, Brown AM, Pitts TM, Tentler JJ, Ciardiello F, Ryan A, Jurgensmeier JM, Eckhardt SG. Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol Cancer Ther 2009, 8:2546-2558. 10.1158/1535-7163.MCT-09-0380, 2819052, 19755510.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2546-2558
    • Morelli, M.P.1    Brown, A.M.2    Pitts, T.M.3    Tentler, J.J.4    Ciardiello, F.5    Ryan, A.6    Jurgensmeier, J.M.7    Eckhardt, S.G.8
  • 33
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • 10.1016/j.ccr.2009.01.021, 19249681
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009, 15:232-239. 10.1016/j.ccr.2009.01.021, 19249681.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 34
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • 10.1016/j.ccr.2009.01.027, 2874829, 19249680
    • Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, Inoue M, Bergers G, Hanahan D, Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009, 15:220-231. 10.1016/j.ccr.2009.01.027, 2874829, 19249680.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Vinals, F.6    Inoue, M.7    Bergers, G.8    Hanahan, D.9    Casanovas, O.10


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