SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the wnt/β-catenin pathway

Oncotarget

Volumn 5, Issue 21, 2014, Pages 10571-10583

  Tong, Xin ^a,b,c   Li, Lili ^d   Li, Xiaoyan ^a,b   Heng, Lei ^a   Zhong, Lan ^d   Su, Xianwei ^d   Rong, Rong ^d   Hu, Shi ^a   Liu, Wenjia ^b   Jia, Baoqing ^b   Liu, Xing ^e   Kou, Geng ^a,c   Han, Jun ^c,f   Guo, Shangjing ^c   Hu, Yi ^b   Li, Cheng ^b   Tao, Qian ^d   Guo, Yajun ^a,b,c,f  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c Liao Cheng University   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e The 150th Central Hospital of People's Liberation Army   (China)

^f Shanghai Key Laboratory of Veterinary Science   (China)

Author keywords

Digestive cancer; Methylation; Sox10; Tumor suppressor gene; Catenin signaling

Indexed keywords

BETA CATENIN; PROTEIN TCF4; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; MESSENGER RNA; SOX10 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; COLORECTAL CANCER; CONTROLLED STUDY; DEMETHYLATION; DNA BINDING; DNA METHYLATION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGUS CANCER; FETUS; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; GENE SILENCING; GENETIC IDENTIFICATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS INHIBITION; MOUSE; MULTIPLE CANCER; NONHUMAN; NORMAL HUMAN; PRIMARY TUMOR; PROMOTER REGION; PROTEIN BINDING; SOX10 GENE; STOMACH CANCER; TUMOR SUPPRESSOR GENE; WNT SIGNALING PATHWAY; ANIMAL; BAGG ALBINO MOUSE; CELL ADHESION; CELL MOTION; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG SCREENING; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; LIVER NEOPLASMS; MELANOMA; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BETA CATENIN; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MALE; MELANOMA; MICE; MICE, INBRED BALB C; MICE, NUDE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOXE TRANSCRIPTION FACTORS; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84916919338     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2512     Document Type: Article

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