New approaches for managing preeclampsia: Clues from clinical and basic research

Clinical Therapeutics

Volumn 36, Issue 12, 2014, Pages 1873-1881

  George, Eric M ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

antihypertensives; preeclampsia; pregnancy; seizures

Indexed keywords

ADALIMUMAB; ANTIHYPERTENSIVE AGENT; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; ETANERCEPT; INFLIXIMAB; PHOSPHODIESTERASE V INHIBITOR; VASCULOTROPIN 121; VASCULOTROPIN 165; FLT1 PROTEIN, HUMAN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ADAPTIVE IMMUNITY; ANTIHYPERTENSIVE THERAPY; AUTOIMMUNITY; BASIC RESEARCH; BLOOD PRESSURE REGULATION; CIRCULATION; CLINICAL RESEARCH; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG STABILITY; DRUG TOLERABILITY; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERTENSION; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; ISCHEMIA; KIDNEY INJURY; NONHUMAN; PLACENTAL ISCHEMIA; PREECLAMPSIA; PREGNANCY; PROTEIN EXPRESSION; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; UTERUS BLOOD FLOW; ANIMAL; FEMALE; HYPOXIA; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PRE-ECLAMPSIA; VASCULARIZATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; FEMALE; HUMANS; HYPOXIA; ISCHEMIA; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84916911956     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2014.09.023     Document Type: Article

References (62)

1. American College of Gynecologists, Task Force on Hypertension in Pregnancy Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy Obstet gynecol 122 2013 1122 1131
2. L. van Eerden, G.G. Zeeman, and G.C. Page-Christiaens Termination of pregnancy for maternal indications at the limits of fetal viability: A retrospective cohort study in the Dutch tertiary care centres BMJ open 4 2014 e005145
3. L.C. Poon, N.A. Kametas, and T. Chelemen Maternal risk factors for hypertensive disorders in pregnancy: A multivariate approach J Hum Hypertens 24 2010 104 110
4. R. Gaillard, E.A. Steegers, A. Hofman, and V.W. Jaddoe Associations of maternal obesity with blood pressure and the risks of gestational hypertensive disorders. The Generation R Study J Hypertens 29 2011 937 944
5. K. Duckitt, and D. Harrington Risk factors for pre-eclampsia at antenatal booking: Systematic review of controlled studies BMJ 330 2005 565
6. M. Hladunewich, S.A. Karumanchi, and R. Lafayette Pathophysiology of the clinical manifestations of preeclampsia Clin J Am Soc Nephrol 2 2007 543 549
7. M.A. Shembrey, and A.D. Noble An instructive case of abdominal pregnancy Aust N Z J Obstet Gynaecol 35 1995 220 221
8. R. Pijnenborg, L. Vercruysse, and I. Brosens Deep placentation Best Pract Res Clin Obstet Gynaecol 25 2011 273 285
9. I.A. Brosens, W.B. Robertson, and H.G. Dixon The role of the spiral arteries in the pathogenesis of preeclampsia Obstet Gynecol Annu 1 1972 177 191
10. X. Zhu, S. Wu, W.L. Dahut, and C.R. Parikh Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis Am J Kidney Dis 49 2007 186 193
11. S.E. Maynard, J.Y. Min, and J. Merchan Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J Clin Invest 111 2003 649 658
12. F.T. Wu, M.O. Stefanini, and F. Mac Gabhann A systems biology perspective on sVEGFR1: Its biological function, pathogenic role and therapeutic use J Cell Mol Med 14 2010 528 552
13. S. Ahmad, and A. Ahmed Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia Circ Res 95 2004 884 891
14. T. Nagamatsu, T. Fujii, and M. Kusumi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: An implication for the placental vascular development and the pathophysiology of preeclampsia Endocrinology 145 2004 4838 4845
15. E.M. George, K. Cockrell, T.H. Adair, and J.P. Granger Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants Am J Physiol Regul Integr Comp Physiol 299 2010 R1629 R1633
16. S.R. Murphy, B.B. LaMarca, K. Cockrell, and J.P. Granger Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats Hypertension 55 2010 394 398
17. A. Bergmann, S. Ahmad, and M. Cudmore Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model J Cell Mol Med 14 2010 1857 1867
18. J.S. Gilbert, J. Verzwyvelt, and D. Colson Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placental ischemia-induced hypertension Hypertension 55 2010 380 385
19. E.M. George, M. Arany, and K. Cockrell Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats Am J Physiol Regul Integr Comp Physiol 301 2011 R1495 R1500
20. J.S. Gilbert, S.A. Babcock, and J.P. Granger Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression Hypertension 50 2007 1142 1147
21. E.M. George, K. Cockrell, and M. Aranay Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension Hypertension 57 2011 941 948
22. Z. Li, Y. Zhang, and M.a.J. Ying Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia Hypertension 50 2007 686 692
23. H. Suzuki, A. Ohkuchi, and S. Matsubara Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice Hypertension 54 2009 1129 1135
24. G. Wallukat, V. Homuth, and T. Fischer Patients with preeclampsia develop agonistic autoantibodies against the angiotensin at1 receptor J Clin Invest 103 1999 945 952
25. A.H. Siddiqui, R.A. Irani, and Y. Zhang Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice Am J Hypertens 2010
26. B. LaMarca, M. Parrish, and L.F. Ray Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-aa) in pregnant rats: Role of endothelin-1 Hypertension 54 2009 905 909
27. R. Thadhani, T. Kisner, and H. Hagmann Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia Circulation 124 2011 940 950
28. S.M. Eppler, D.L. Combs, and T.D. Henry A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans Clin Pharmacol Ther 72 2002 20 32
29. L. Miquerol, B.L. Langille, and A. Nagy Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression Development 127 2000 3941 3946
30. Y. He, S.K. Smith, and K.A. Day Alternative splicing of vascular endothelial growth factor (VEGF)-r1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity Mol Endocrinol 13 1999 537 545
31. M.J. Kupferminc, A.M. Peaceman, and T.R. Wigton Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia Am J Obstet Gynecol 170 1994 1752 1757 discussion 1757-1759
32. G.S. Vince, P.M. Starkey, and R. Austgulen Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia Br J Obstet Gynaecol 102 1995 20 25
33. B. LaMarca, J. Speed, and L. Fournier Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of tumor necrosis factor-alpha blockade Hypertension 52 2008 1161 1167
34. G. Gadonski, B.B. LaMarca, and E. Sullivan Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of interleukin 6 Hypertension 48 2006 711 716
35. B.T. Alexander, K.L. Cockrell, and M.B. Massey Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression Am J Hypertens 15 2002 170 175
36. B.B. LaMarca, K. Cockrell, and E. Sullivan Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats Hypertension 46 2005 82 86
37. J. Gutkowska, J.P. Granger, and B.B. Lamarca Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: Effect of tumor necrosis factor blockade J Hypertens 29 2011 1203 1212
38. G. Murdaca, B.M. Colombo, and P. Cagnati Update upon efficacy and safety of TNF-alpha inhibitors Expert Opin Drug Saf 11 2012 1 5
39. R.M. Marchioni, and G.R. Lichtenstein Tumor necrosis factor-alpha inhibitor therapy and fetal risk: A systematic literature review World J Gastroenterol 19 2013 2591 2602
40. B. LaMarca, G. Wallukat, and M. Llinas Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats Hypertension 52 2008 1168 1172
41. K. Gersak, M. Cvijic, and L.K. Cerar Angiotensin II receptor blockers in pregnancy: A report of five cases Reproductive toxicology 28 2009 109 112
42. S. Alwan, J.E. Polifka, and J.M. Friedman Angiotensin II receptor antagonist treatment during pregnancy Birth Defects Res A Clin Mol Teratol 73 2005 123 130
43. C.C. Zhou, Y. Zhang, and R.A. Irani Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice Nat Med 14 2008 855 862
44. D.O. Anumba, S.C. Robson, R.J. Boys, and G.A. Ford Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy Am J Physiol 277 1999 H848 H854
45. K.P. Conrad, and K.A. Vernier Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats Am J Physiol 257 1989 R847 R853
46. R.A. Khalil, J.K. Crews, and J. Novak Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats Hypertension 31 1998 1065 1069
47. S.R. Abram, B.T. Alexander, W.A. Bennett, and J.P. Granger Role of neuronal nitric oxide synthase in mediating renal hemodynamic changes during pregnancy Am J Physiol Regul Integr Comp Physiol 281 2001 R1390 R1393
48. F. Lyall, A. Young, and I.A. Greer Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia Am J Obstet Gynecol 173 1995 714 718
49. J.K. Crews, J.N. Herrington, J.P. Granger, and R.A. Khalil Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat Hypertension 35 2000 367 372
50. L.A. Danielson, and K.P. Conrad Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats J Clin Invest 96 1995 482 490
51. M. Molnar, T. Suto, T. Toth, and F. Hertelendy Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation Am J Obstet Gynecol 170 1994 1458 1466
52. K.H. Coppage, X. Sun, R.S. Baker, and K.E. Clark Expression of phosphodiesterase 5 in maternal and fetal sheep Am J Obstet Gynecol 193 2005 1005 1010
53. R.A. Samangaya, G. Mires, and A. Shennan A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia Hypertens Pregnancy 28 2009 369 382
54. J. Downing Sildenafil for the treatment of preeclampsia Hypertens Pregnancy 29 2010 248 250 (author reply 251-242)
55. E.M. George, A.C. Palei, E.A. Dent, and J.P. Granger Sildenafil attenuates placental ischemia-induced hypertension Am J Physiol Regul Integr Comp Physiol 305 2013 R397 R403
56. J.M. Sasser, X.P. Ni, M.H. Humphreys, and C. Baylis Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat Am J Physiol Renal Physiol 299 2010 F810 F814
57. B.T. Alexander, A.N. Rinewalt, and K.L. Cockrell Endothelin type a receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure Hypertension 37 2001 485 489
58. L. Roberts, B.B. LaMarca, and L. Fournier Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion Hypertension 47 2006 615 618
59. D.E. Clouthier, K. Hosoda, and J.A. Richardson Cranial and cardiac neural crest defects in endothelin-a receptor-deficient mice Development 125 1998 813 824
60. T. Taniguchi, and I. Muramatsu Pharmacological knockout of endothelin et(a) receptors Life Sci 74 2003 405 409
61. L.G. Thaete, M.G. Neerhof, and R.K. Silver Differential effects of endothelin A and B receptor antagonism on fetal growth in normal and nitric oxide-deficient rats J Soc Gynecol Investig 8 2001 18 23
62. M.L. Webb, K.E. Dickinson, and C.L. Delaney The endothelin receptor antagonist, BQ-123, inhibits angiotensin II-induced contractions in rabbit aorta Biochem Biophys Res Commun 185 1992 887 892