Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat

American Journal of Physiology - Renal Physiology

Volumn 299, Issue 4, 2010, Pages

  Sasser, Jennifer M ^a   Ni, Xi Ping ^c   Humphreys, Michael H ^c   Baylis, Chris ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cGMP; Inner medulla; Sildenafil; Sodium nitroprusside; Sodium retention; Spermine NONOate

Indexed keywords

CYCLIC GMP; NATRIURETIC PEPTIDE RECEPTOR A; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; SPERMINE; ENZYME INHIBITOR; NITRIC OXIDE DONOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INFUSION; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY COLLECTING TUBULE; KIDNEY MEDULLA; MEAN ARTERIAL PRESSURE; NATRIURESIS; NONHUMAN; PLASMA VOLUME; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RAT; SODIUM EXCRETION; SODIUM TRANSPORT; VIRGIN ISLANDS (BRITISH); ANIMAL; ANIMAL MODEL; BREEDING; DRUG EFFECTS; KIDNEY; METABOLISM; PHYSIOLOGY;

ANIMALS; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENZYME INHIBITORS; FEMALE; KIDNEY; MODELS, ANIMAL; NATRIURESIS; NITRIC OXIDE DONORS; NITROPRUSSIDE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PREGNANCY; PREGNANCY, ANIMAL; PURINES; RATS; SPERMINE; SULFONES;

EID: 77957980164     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00117.2010     Document Type: Article

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