Differential effects of endothelin A and B receptor antagonism on fetal growth in normal and nitric oxide-deficient rats

Journal of the Society for Gynecologic Investigation

Volumn 8, Issue 1, 2001, Pages 18-23

  Thaete, Larry G ^a,b   Neerhof, Mark G ^a   Silver, Richard K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b EVANSTON NORTHWESTERN HEALTHCARE   (United States)

Author keywords

Endothelin receptor antagonism; Intrauterine growth restriction; N nitro L arginine methyl ester (L NAME); Nitric oxide synthase inhibition; Rat

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; A 182086; ATRASENTAN; ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS GROWTH; FETUS WEIGHT; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; PLACENTA DEVELOPMENT; PLACENTA WEIGHT; PRIORITY JOURNAL; RAT;

ANIMALS; AZEPINES; EMBRYONIC AND FETAL DEVELOPMENT; ENZYME INHIBITORS; FEMALE; FETAL GROWTH RETARDATION; INDOLES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLACENTA; PREGNANCY; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN;

EID: 0035793040     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(00)00119-2     Document Type: Article

References (31)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies
3. Endothelial vasoactive mediators in preeclampsia
4. Maternal plasma level of endothelin is increased in preeclampsia
5. Endothelin-1,2 levels in umbilical vein serum of intra-uterine growth retarded fetuses as detected by cordocentesis
6. Fetal endothelin levels and placental vascular endothelin receptors in intrauterine growth retardation
7. Maternal plasma endothelin levels and fetal status in normal and preeclamptic pregnancies
8. B receptors
9. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
10. B receptors in rats
11. Endothelin-1-induced placental and fetal growth restriction in the rat
12. Chronic NOS-inhibition-induced IUGR is associated with increased circulating endothelin-1 levels in the rat
13. Long-term nitric oxide blockade in the pregnant rat; Effects on blood pressure and plasma levels of endothelin-1
14. Placental perfusion is decreased in a dose-dependent fashion in chronic NOS-inhibition-induced IUGR
15. Endothelin and blood pressure regulation in the female rat; Studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension
16. A-selective receptor antagonist
17. A receptor antagonist
18. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat
19. Limb reduction defects after prenatal inhibition of nitric oxide synthase in rats
20. Nitric oxide inhibition causes intrauterine growth retardation and hind-limb disruptions in rats
21. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
22. Termination of endothelin signaling; Role of nitric oxide
23. Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats
24. Actions of endothelin-1 on cultured rat renomedullary interstitial cells are modulated by nitric oxide
25. Chronic blockade of nitric oxide-synthase and endothelin receptors during pregnancy in the rat; Effect on pregnancy outcome
26. Developmental toxicity and toxicokinetics of two endothelin receptor antagonists in rats and rabbits
27. Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat
28. Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade in conscious pregnant rats
29. A nitric oxide synthesis inhibitor decreased prostaglandin production in rat mesenteric vasculature
30. The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia
31. Principal substrates of fetal metabolism