메뉴 건너뛰기




Volumn 193, Issue 12, 2014, Pages 5973-5982

Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CD4 ANTIGEN; CD8 ANTIGEN; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ANTIGEN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84916899855     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400839     Document Type: Article
Times cited : (33)

References (52)
  • 1
    • 84861235503 scopus 로고    scopus 로고
    • Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
    • Wang, D., M. Zheng, L. Lei, J. Ji, Y. Yao, Y. Qiu, L. Ma, J. Lou, C. Ouyang, X. Zhang, et al. 2012. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat. Immunol. 13: 560-568.
    • (2012) Nat. Immunol. , vol.13 , pp. 560-568
    • Wang, D.1    Zheng, M.2    Lei, L.3    Ji, J.4    Yao, Y.5    Qiu, Y.6    Ma, L.7    Lou, J.8    Ouyang, C.9    Zhang, X.10
  • 2
    • 0037097635 scopus 로고    scopus 로고
    • The absence of Itk inhibits positive selection without changing lineage commitment
    • Lucas, J. A., L. O. Atherly, and L. J. Berg. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J. Immunol. 168: 6142-6151.
    • (2002) J. Immunol. , vol.168 , pp. 6142-6151
    • Lucas, J.A.1    Atherly, L.O.2    Berg, L.J.3
  • 4
    • 0034305495 scopus 로고    scopus 로고
    • Control of pre-T cell proliferation and differentiation by the GTPase Rac-I
    • Gomez, M., V. Tybulewicz, and D. A. Cantrell. 2000. Control of pre-T cell proliferation and differentiation by the GTPase Rac-I. Nat. Immunol. 1: 348-352.
    • (2000) Nat. Immunol. , vol.1 , pp. 348-352
    • Gomez, M.1    Tybulewicz, V.2    Cantrell, D.A.3
  • 5
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11: 2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 6
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420: 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 7
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C. D., and A. Hall. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81: 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 8
    • 0033551698 scopus 로고    scopus 로고
    • Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation
    • Lin, R., R. A. Cerione, and D. Manor. 1999. Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J. Biol. Chem. 274: 23633-23641.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23633-23641
    • Lin, R.1    Cerione, R.A.2    Manor, D.3
  • 9
    • 1642580743 scopus 로고    scopus 로고
    • Involvement of Rho family GTPases in p19Arfand p53-mediated proliferation of primary mouse embryonic fibroblasts
    • Guo, F., and Y. Zheng. 2004. Involvement of Rho family GTPases in p19Arfand p53-mediated proliferation of primary mouse embryonic fibroblasts. Mol. Cell. Biol. 24: 1426-1438.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1426-1438
    • Guo, F.1    Zheng, Y.2
  • 10
    • 0032541613 scopus 로고    scopus 로고
    • Rho family proteins and Ras transformation: The RHOad less traveled gets congested
    • Zohn, I. M., S. L. Campbell, R. Khosravi-Far, K. L. Rossman, and C. J. Der. 1998. Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17(11 Reviews): 1415-1438.
    • (1998) Oncogene , vol.17 , Issue.11 REVIEWS , pp. 1415-1438
    • Zohn, I.M.1    Campbell, S.L.2    Khosravi-Far, R.3    Rossman, K.L.4    Der, C.J.5
  • 11
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • Olson, M. F., A. Ashworth, and A. Hall. 1995. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272.
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, M.F.1    Ashworth, A.2    Hall, A.3
  • 13
    • 0032700438 scopus 로고    scopus 로고
    • Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
    • del Pozo, M. A., M. Vicente-Manzanares, R. Tejedor, J. M. Serrador, and F. Sánchez-Madrid. 1999. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur. J. Immunol. 29: 3609-3620.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3609-3620
    • Del Pozo, M.A.1    Vicente-Manzanares, M.2    Tejedor, R.3    Serrador, J.M.4    Sánchez-Madrid, F.5
  • 14
    • 77955887642 scopus 로고    scopus 로고
    • Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration
    • Heasman, S. J., L. M. Carlin, S. Cox, T. Ng, and A. J. Ridley. 2010. Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J. Cell Biol. 190: 553-563.
    • (2010) J. Cell Biol. , vol.190 , pp. 553-563
    • Heasman, S.J.1    Carlin, L.M.2    Cox, S.3    Ng, T.4    Ridley, A.J.5
  • 16
    • 84861746032 scopus 로고    scopus 로고
    • The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes
    • Mou, F., M. Praskova, F. Xia, D. Van Buren, H. Hock, J. Avruch, and D. Zhou. 2012. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J. Exp. Med. 209: 741-759.
    • (2012) J. Exp. Med. , vol.209 , pp. 741-759
    • Mou, F.1    Praskova, M.2    Xia, F.3    Van Buren, D.4    Hock, H.5    Avruch, J.6    Zhou, D.7
  • 17
    • 0035476474 scopus 로고    scopus 로고
    • Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo
    • Corre, I., M. Gomez, S. Vielkind, and D. A. Cantrell. 2001. Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J. Exp. Med. 194: 903-914.
    • (2001) J. Exp. Med. , vol.194 , pp. 903-914
    • Corre, I.1    Gomez, M.2    Vielkind, S.3    Cantrell, D.A.4
  • 18
    • 0030946814 scopus 로고    scopus 로고
    • The GTPase Rho has a critical regulatory role in thymus development
    • Henning, S.W., R. Galandrini, A. Hall, and D. A. Cantrell. 1997. The GTPase Rho has a critical regulatory role in thymus development. EMBO J. 16: 2397-2407.
    • (1997) EMBO J. , vol.16 , pp. 2397-2407
    • Henning, S.W.1    Galandrini, R.2    Hall, A.3    Cantrell, D.A.4
  • 19
    • 0030806477 scopus 로고    scopus 로고
    • Different functions of the GTPase Rho in prothymocytes and late pre-T cells
    • Galandrini, R., S. W. Henning, and D. A. Cantrell. 1997. Different functions of the GTPase Rho in prothymocytes and late pre-T cells. Immunity 7: 163-174.
    • (1997) Immunity , vol.7 , pp. 163-174
    • Galandrini, R.1    Henning, S.W.2    Cantrell, D.A.3
  • 20
    • 0035668525 scopus 로고    scopus 로고
    • Dbl family guanine nucleotide exchange factors
    • Zheng, Y. 2001. Dbl family guanine nucleotide exchange factors. Trends Biochem. Sci. 26: 724-732.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 724-732
    • Zheng, Y.1
  • 21
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • Bishop, A. L., and A. Hall. 2000. Rho GTPases and their effector proteins. Biochem. J. 348: 241-255.
    • (2000) Biochem. J. , vol.348 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 22
    • 33745833345 scopus 로고    scopus 로고
    • Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    • Guo, F., M. Debidda, L. Yang, D. A. Williams, and Y. Zheng. 2006. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J. Biol. Chem. 281: 18652-18659.
    • (2006) J. Biol. Chem. , vol.281 , pp. 18652-18659
    • Guo, F.1    Debidda, M.2    Yang, L.3    Williams, D.A.4    Zheng, Y.5
  • 23
    • 0942265527 scopus 로고    scopus 로고
    • Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant
    • Debreceni, B., Y. Gao, F. Guo, K. Zhu, B. Jia, and Y. Zheng. 2004. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. J. Biol. Chem. 279: 3777-3786.
    • (2004) J. Biol. Chem. , vol.279 , pp. 3777-3786
    • Debreceni, B.1    Gao, Y.2    Guo, F.3    Zhu, K.4    Jia, B.5    Zheng, Y.6
  • 24
    • 0028790399 scopus 로고
    • Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins
    • Aktories, K., and I. Just. 1995. Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins. Trends Cell Biol. 5: 441-443.
    • (1995) Trends Cell Biol. , vol.5 , pp. 441-443
    • Aktories, K.1    Just, I.2
  • 25
    • 79955382980 scopus 로고    scopus 로고
    • RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts
    • Melendez, J., K. Stengel, X. Zhou, B. K. Chauhan, M. Debidda, P. Andreassen, R. A. Lang, and Y. Zheng. 2011. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J. Biol. Chem. 286: 15132-15137.
    • (2011) J. Biol. Chem. , vol.286 , pp. 15132-15137
    • Melendez, J.1    Stengel, K.2    Zhou, X.3    Chauhan, B.K.4    Debidda, M.5    Andreassen, P.6    Lang, R.A.7    Zheng, Y.8
  • 27
    • 80053081290 scopus 로고    scopus 로고
    • Miz-1 is required to coordinate the expression of TCRb and p53 effector genes at the pre-TCR "β-selection" checkpoint
    • Saba, I., C. Kosan, L. Vassen, L. Klein-Hitpass, and T. Möröy. 2011. Miz-1 is required to coordinate the expression of TCRb and p53 effector genes at the pre-TCR "β-selection" checkpoint. J. Immunol. 187: 2982-2992.
    • (2011) J. Immunol. , vol.187 , pp. 2982-2992
    • Saba, I.1    Kosan, C.2    Vassen, L.3    Klein-Hitpass, L.4    Möröy, T.5
  • 28
    • 0027079356 scopus 로고
    • Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck
    • Anderson, S. J., K. M. Abraham, T. Nakayama, A. Singer, and R. M. Perlmutter. 1992. Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J. 11: 4877-4886.
    • (1992) EMBO J. , vol.11 , pp. 4877-4886
    • Anderson, S.J.1    Abraham, K.M.2    Nakayama, T.3    Singer, A.4    Perlmutter, R.M.5
  • 29
    • 0037007023 scopus 로고    scopus 로고
    • Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    • King, A. G., M. Kondo, D. C. Scherer, and I. L. Weissman. 2002. Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling. Proc. Natl. Acad. Sci. USA 99: 4508-4513.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4508-4513
    • King, A.G.1    Kondo, M.2    Scherer, D.C.3    Weissman, I.L.4
  • 30
    • 84893181290 scopus 로고    scopus 로고
    • Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity
    • Dott, W., P. Mistry, J. Wright, K. Cain, and K. E. Herbert. 2014. Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity. Redox Biol. 2: 224-233.
    • (2014) Redox Biol. , vol.2 , pp. 224-233
    • Dott, W.1    Mistry, P.2    Wright, J.3    Cain, K.4    Herbert, K.E.5
  • 33
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
    • Ciofani, M., and J. C. Zúñiga-Pflücker. 2005. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat. Immunol. 6: 881-888.
    • (2005) Nat. Immunol. , vol.6 , pp. 881-888
    • Ciofani, M.1    Zúñiga-Pflücker, J.C.2
  • 36
    • 58149300250 scopus 로고    scopus 로고
    • Protein kinase C-θ is required for efficient positive selection
    • Morley, S. C., K. S. Weber, H. Kao, and P. M. Allen. 2008. Protein kinase C-θ is required for efficient positive selection. J. Immunol. 181: 4696-4708.
    • (2008) J. Immunol. , vol.181 , pp. 4696-4708
    • Morley, S.C.1    Weber, K.S.2    Kao, H.3    Allen, P.M.4
  • 39
    • 77956182563 scopus 로고    scopus 로고
    • Actin cytoskeleton dynamics and the cell division cycle
    • Heng, Y. W., and C. G. Koh. 2010. Actin cytoskeleton dynamics and the cell division cycle. Int. J. Biochem. Cell Biol. 42: 1622-1633.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1622-1633
    • Heng, Y.W.1    Koh, C.G.2
  • 41
    • 66249108601 scopus 로고    scopus 로고
    • Understanding theWarburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., L. C. Cantley, and C. B. Thompson. 2009. Understanding theWarburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 44
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen, C., Y. Liu, R. Liu, T. Ikenoue, K. L. Guan, Y. Liu, and P. Zheng. 2008. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205: 2397-2408.
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 47
    • 79960369458 scopus 로고    scopus 로고
    • HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi, L. Z., R. Wang, G. Huang, P. Vogel, G. Neale, D. R. Green, and H. Chi. 2011. HIF1a-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208: 1367-1376.
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6    Chi, H.7
  • 48
    • 84890137621 scopus 로고    scopus 로고
    • T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
    • Yang, K., S. Shrestha, H. Zeng, P. W. Karmaus, G. Neale, P. Vogel, D. A. Guertin, R. F. Lamb, and H. Chi. 2013. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39: 1043-1056.
    • (2013) Immunity , vol.39 , pp. 1043-1056
    • Yang, K.1    Shrestha, S.2    Zeng, H.3    Karmaus, P.W.4    Neale, G.5    Vogel, P.6    Guertin, D.A.7    Lamb, R.F.8    Chi, H.9
  • 51
    • 77957829891 scopus 로고    scopus 로고
    • Role of calcium and ROS in cell death induced by polyunsaturated fatty acids in murine thymocytes
    • Prasad, A., M. S. Bloom, and D. O. Carpenter. 2010. Role of calcium and ROS in cell death induced by polyunsaturated fatty acids in murine thymocytes. J. Cell. Physiol. 225: 829-836.
    • (2010) J. Cell. Physiol. , vol.225 , pp. 829-836
    • Prasad, A.1    Bloom, M.S.2    Carpenter, D.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.