ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease

Biomaterials

Volumn 41, Issue , 2015, Pages 166-175

  Poole, Kristin M ^a   Nelson, Christopher E ^a   Joshi, Rucha V ^a   Martin, John R ^a   Gupta, Mukesh K ^a   Haws, Skylar C ^a   Kavanaugh, Taylor E ^a   Skala, Melissa C ^a   Duvall, Craig L ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Antioxidant; Diabetes; Hind limb ischemia; Inflammation; ROS; Smart polymer

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; CELL DEATH; CONTROLLED DRUG DELIVERY; DISEASE CONTROL; DISEASES; EMULSIFICATION; EMULSIONS; IMAGING TECHNIQUES; MAMMALS; MEDICAL PROBLEMS; MICROSPHERES; SMART POLYMERS; SULFUR COMPOUNDS;

CHRONIC INFLAMMATORY DISEASE; HIND LIMBS; HYDROGEN PEROXIDE CONCENTRATION; INFLAMMATION; OIL-IN-WATER EMULSIONS; PERIPHERAL ARTERIAL DISEASE; PHARMACOKINETIC PROPERTIES; POLY(PROPYLENE SULFIDE) (PPS);

TARGETED DRUG DELIVERY;

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CURCUMIN; HYDROGEN PEROXIDE; MICROSPHERE; POLY(PROPYLENE SULFIDE); PROPYLENE; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG; CCL2 PROTEIN, MOUSE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXYGEN; POLYMER; SULFIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG RELEASE; DRUG SYNTHESIS; EMULSION; EXPERIMENTAL MODEL; HYDROPHILICITY; HYDROPHOBICITY; LIMB ISCHEMIA; MACROPHAGE; MALE; MICROENCAPSULATION; MOUSE; MUSCLE LEVEL; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OXIDATIVE STRESS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; 3T3 CELL LINE; ANIMAL; BLOOD; CELL SURVIVAL; CHEMISTRY; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENDOCYTOSIS; FEMALE; HINDLIMB; INTRACELLULAR SPACE; ISCHEMIA; KINETICS; MACROPHAGE ACTIVATION; METABOLISM; MUSCLE; PARTICLE SIZE; PATHOLOGY; PERFUSION; PERIPHERAL ARTERIAL DISEASE; SECRETION (PROCESS); SYNTHESIS; VASCULARIZATION;

MUS;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CHEMOKINE CCL2; CURCUMIN; DIABETES MELLITUS, EXPERIMENTAL; ENDOCYTOSIS; FEMALE; HINDLIMB; HYDROGEN PEROXIDE; INTERFERON-GAMMA; INTRACELLULAR SPACE; ISCHEMIA; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MICE; MICROSPHERES; MUSCLES; NIH 3T3 CELLS; OXYGEN; PARTICLE SIZE; PERFUSION; PERIPHERAL ARTERIAL DISEASE; POLYMERS; REACTIVE OXYGEN SPECIES; SULFIDES;

EID: 84916898421     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.11.016     Document Type: Article

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