Andrographolide inhibits melanoma tumor growth by inactivating the TLR4/NF-κB signaling pathway

Melanoma Research

Volumn 24, Issue 6, 2014, Pages 545-555

  Zhang, Qian Qian ^a   Zhou, Da Lei ^a   Ding, Yi ^a   Liu, Hong Ying ^a   Lei, Yan ^a   Fang, Hai Yan ^a   Gu, Qu Liang ^a   He, Xiao Dong ^a   Qi, Cui Ling ^a   Yang, Yi ^b   Lan, Tian ^a   Li, Jiang Chao ^a   Gong, Ping ^a   Wu, Xiao Yun ^a   Yang, Xuesong ^c   Li, Wei Dong ^a   Wang, Li Jing ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b PCFM Laboratory   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

Andrographolide; Growth; Melanoma; Metastasis

Indexed keywords

ANDROGRAPHOLIDE; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; PROTEIN BCL 6; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TOLL LIKE RECEPTOR 4; ANTIINFLAMMATORY AGENT; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG EFFECT; FEMALE; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECTS; EXPERIMENTAL MELANOMA; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; SECONDARY; SKIN TUMOR; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DOWN-REGULATION; FEMALE; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NF-KAPPA B; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TOLL-LIKE RECEPTOR 4; TUMOR BURDEN;

EID: 84916882051     PISSN: 09608931     EISSN: 14735636     Source Type: Journal    
DOI: 10.1097/CMR.0000000000000117     Document Type: Article

References (33)

1. Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ. Early detection and treatment of skin cancer. Am Fam Physician 2000; 62:357-368.
2. Takeda K, Akira S. TLR signaling pathways. Semin Immunol 2004; 16:3-9.
3. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 2010; 11:373-384.
4. Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 2007; 133:1869-1881.
5. Goto Y, Arigami T, Kitago M, Nguyen SL, Narita N, Ferrone S, et al. Activation of toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther 2008; 7:3642-3653.
6. Pratheeshkumar P, Sheeja K, Kuttan G. Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated Bcl-2 activation and modulating p53-induced caspase-3 gene expression. Immunopharmacol Immunotoxicol 2012; 34:143-151.
7. Zhou J, Zhang S, Ong CN, Shen HM. Critical role of pro-apoptotic Bcl-2 family members in and rographolide-induced apoptosis in human cancer cells. Biochem Pharmacol 2006; 72:132-144.
8. Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 2003; 3:147-158.
9. Zhou WJ, Geng ZH, Chi S, Zhang W, Niu XF, Lan SJ, et al. Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res 2011; 21:609-626.
10. Handa SS, Sharma A. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res 1990; 92:276-283.
11. Wang LJ, Zhao Y, Han B, Ma YG, Zhang J, Yang DM, et al. Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis. Cancer Sci 2008; 99:510-517.
12. Zhang QQ, Xu H, Huang MB, Ma LM, Huang QJ, Yao Q, et al. MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol 2012; 14:278-287.
13. Maciorowski Z, Delic J, Padoy E, Klijanienko J, Dubray B, Cosset JM, et al. Comparative analysis of apoptosis measured by Hoechst and flow cytometry in non-Hodgkin's lymphomas. Cytometry 1998; 32:44-50.
14. Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 2004; 173:4207-4217.
15. Iruretagoyena MI, Tobar JA, González PA, Sepúlveda SE, Figueroa CA, Burgos RA, et al. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J Pharmacol Exp Ther 2005; 312:366-372.
16. Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol 2002; 135:399-406.
17. Wang AC, Ma YB, Wu FX, Ma ZF, Liu NF, Gao R, et al. TLR4 induces tumor growth and inhibits paclitaxel activity in MyD88-positive human ovarian carcinoma in vitro. Oncol Lett 2014; 7:871-877.
18. Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, et al. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. Ann Surg Oncol 2009; 16:1043-1050.
19. Rakhesh M, Cate M, Vijay R, Shrikant A, Shanjana A. A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells. Oncoimmunology 2012; 1:1495-1506.
20. Lapteva N, Yang AG, Sanders DE, Strube RW, Chen SY. CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo. Cancer Gene Ther 2005; 12:84-89.
21. Yu T, Wu Y, Huang Y, Yan C, Liu Y, Wang Z, et al. RNAi targeting CXCR4 inhibits tumor growth through inducing cell cycle arrest and apoptosis. Mol Ther 2012; 20:398-407.
22. Kim M, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res 2010; 70:10411-10421.
23. Lombardi L, Tavano F, Morelli F, Latiano TP, Di Sebastiano P, Maiello E. Chemokine receptor CXCR4: role in gastrointestinal cancer. Crit Rev Oncol Hematol 2013; 88:696-705.
24. Pinto AE, André S, Silva G, Vieira S, Santos AC, Dias S, Soares J. BCL-6 oncoprotein in breast cancer: loss of expression in disease progression. Pathobiology 2009; 76:235-242.
25. Helbig G, Christopherson KW II, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, et al. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 2003; 278:21631-21638.
26. Hsieh CY, Hsu MJ, Hsiao G, Wang YH, Huang CW, Chen SW, et al. Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells. J Biol Chem 2011; 286:5942-5955.
27. Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 2004; 92:291-295.
28. Kim TG, Hwi KK, Hung CS. Morphological and biochemical changes of andrographolide-induced cell death in human prostatic adenocarcinoma PC-3 cells. In Vivo 2005; 19:551-557.
29. Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, et al. Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation. J Dent Res 2011; 90:1246-1252.
30. Kumar S, Patil HS, Sharma P, Kumar D, Dasari S, Puranik VG, et al. Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway. Curr Mol Med 2012; 12:952-966.
31. Li Y, Zhang P, Qiu F, Chen L, Miao C, Li J, et al. Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells. Life Sci 2012; 90:962-967.
32. Li J, Cheung HY, Zhang Z, Chan GK, Fong WF. Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species. Eur J Pharmacol 2007; 568:31-44.
33. Shi MD, Lin HH, Lee YC, Chao JK, Lin RA, Chen JH. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem Biol Interact 2008; 174:201-210.