O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: Implications for anti-glioma therapies

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Sasai, Ken ^a   Akagi, Tsuyoshi ^b   Aoyanagi, Eiko ^a   Tabu, Kouichi ^a   Kaneko, Sadao ^c   Tanaka, Shinya ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KAN Research Institute Inc ^*  (Japan)

^c Kashiwaba Neurosurgical Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; HISTONE; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; VALPROIC ACID; ANTINEOPLASTIC AGENT; DACARBAZINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; MGMT PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RECOMBINANT PROTEIN; TEMOZOLOMIDE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL TRANSFORMATION; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE CONTROL; GENE TRANSFER; GENETIC MANIPULATION; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; MONOTHERAPY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; ANIMAL; CELL DIVISION; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOGRAFT;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTES; CELL DIVISION; DACARBAZINE; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; GLIOMA; HUMANS; MICE; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS; VALPROIC ACID;

EID: 34250802722     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-36     Document Type: Article

References (37)

1. Kleihues P Burger PC Scheithauer BW The new WHO classification of brain tumours Brain Pathol 1993 3 255-268 8293185
2. Kleihues P Louis DN Scheithauer BW Rorke LB Reifenberger G Burger PC Cavenee WK The WHO classification of tumors of the nervous system J Neuropathol Exp Neurol 2002 61 215-225 discussion 226-219 11895036
3. Ohgaki H Dessen P Jourde B Horstmann S Nishikawa T Di Patre PL Burkhard C Schuler D Probst-Hensch NM Maiorka PC Genetic pathways to glioblastoma: A population-based study Cancer Res 2004 64 6892-6899 10.1158/0008-5472.CAN-04-1337 15466178
4. Reardon DA Rich JN Friedman HS Bigner DD Recent advances in the treatment of malignant astrocytoma J Clin Oncol 2006 24 1253-1265 10.1200/JCO.2005.04.5302 16525180
5. Stupp R Gander M Leyvraz S Newlands E Current and future developments in the use of temozolomide for the treatment of brain tumours Lancet Oncol 2001 2 552-560 10.1016/S1470-2045(01)00489-2 11905710
6. Gerson SL MGMT: Its role in cancer aetiology and cancer therapeutics Nat Rev Cancer 2004 4 296-307 10.1038/nrc1319 15057289
7. Akagi T Oncogenic transformation of human cells: Shortcomings of rodent model systems Trends Mol Med 2004 10 542-548 10.1016/ j.molmed.2004.09.001 15519280
8. Zhao JJ Roberts TM Hahn WC Functional genetics and experimental models of human cancer Trends Mol Med 2004 10 344-350 10.1016/ j.molmed.2004.05.005 15242683
9. Hu X Holland EC Applications of mouse glioma models in preclinical trials Mutat Res 2005 576 54-65 16011838
10. Sonoda Y Ozawa T Hirose Y Aldape KD McMahon M Berger MS Pieper RO Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma Cancer Res 2001 61 4956-4960 11431323
11. Sonoda Y Ozawa T Aldape KD Deen DF Berger MS Pieper RO Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma Cancer Res 2001 61 6674-6678 11559533
12. Colella S Ohgaki H Ruediger R Yang F Nakamura M Fujisawa H Kleihues P Walter G Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes Int J Cancer 2001 93 798-804 10.1002/ijc.1423 11519040
13. Arroyo JD Hahn WC Involvement of PP2A in viral and cellular transformation Oncogene 2005 24 7746-7755 10.1038/sj.onc.1209038 16299534
14. Akagi T Sasai K Hanafusa H Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation Proc Natl Acad Sci USA 2003 100 13567-13572 263854 14597713 10.1073/pnas.1834876100
15. Sasai K Kakumoto K Hanafusa H Akagi T The Ras-MAPK pathway downregulates Caveolin-1 in rodent fibroblast but not in human fibroblasts: implications in the resistance to oncogene-mediated transformation Oncogene 2007 26 449-455 10.1038/sj.onc.1209792 16832346
16. Kakumoto K Sasai K Sukezane T Oneyama C Ishimaru S Shibutani K Mizushima H Mekada E Hanafusa H Akagi T FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts Proc Natl Acad Sci USA 2006 103 5490 5495 1459382 16569692 10.1073/ pnas.0601222103
17. Sukezane T Oneyama C Kakumoto K Shibutani K Hanafusa H Akagi T Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras Oncogene 2005 24 5648-5655 10.1038/sj.onc.1208724 16007212
18. Silber JR Mueller BA Ewers TG Berger MS Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain Cancer Res 1993 53 3416-3420 8324751
19. Ordway JM Fenster SD Ruan H Curran T A transcriptome map of cellular transformation by the fos oncogene Mol Cancer 2005 4 19 1177986 15918904 10.1186/1476-4598-4-19
20. A transcriptome map of cellular transformation by the Fos oncogene http://www.stjuderesearch.org/v-fosSOM/
21. Zhu WG Otterson GA The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells Curr Med Chem Anticancer Agents 2003 3 187-199 10.2174/1568011033482440 12769777
22. Russell SJ Ye YW Waber PG Shuford M Schold SC Jr Nisen PD p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors Cancer 1995 75 1339-1342 10.1002/ 1097-0142(19950315)75:6<1339::AID-CNCR2820750616>3.0.CO;2-F 7882284
23. Rolhion C Penault-Llorca F Kemeny JL Kwiatkowski F Lemaire JJ Chollet P Finat-Duclos F Verrelle P O(6)-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation Int J Cancer 1999 84 416-420 10.1002/(SICI)1097-0215(19990820)84:4<416::AID-IJC15>3.0.CO;2-A 10404096
24. Yuan Q Matsumoto K Nakabeppu Y Iwaki T A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas Neuropathology 2003 23 203-209 10.1046/j.1440-1789.2003.00504.x 14570288
25. Roos WP Batista LF Naumann SC Wick W Weller M Menck CF Kaina B Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine Oncogene 2007 26 186-197 10.1038/sj.onc.1209785 16819506
26. Ishii N Maier D Merlo A Tada M Sawamura Y Diserens AC Van Meir EG Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines Brain Pathol 1999 9 469-479 10416987
27. Natsume A Ishii D Wakabayashi T Tsuno T Hatano H Mizuno M Yoshida J IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide Cancer Res 2005 65 7573-7579 16140920
28. Blough MD Zlatescu MC Cairncross JG O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells Cancer Res 2007 67 580-584 10.1158/0008-5472.CAN-06-2782 17234766
29. Gottlicher M Minucci S Zhu P Kramer OH Schimpf A Giavara S Sleeman JP Lo Coco F Nervi C Pelicci PG Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells Embo J 2001 20 6969-6978 125788 11742974 10.1093/emboj/20.24.6969
30. Bacon CL Gallagher HC Haughey JC Regan CM Antiproliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase J Neurochem 2002 83 12-19 10.1046/j.1471-4159.2002.01081.x 12358724
31. Wagner S Csatary CM Gosztonyi G Koch HC Hartmann C Peters O Hernaiz-Driever P Theallier-Janko A Zintl F Langler A Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid Apmis 2006 114 731-743 10.1111/ j.1600-0463.2006.apm_516.x 17004977
32. Hoon DS Spugnardi M Kuo C Huang SK Morton DL Taback B Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients Oncogene 2004 23 4014-4022 10.1038/ sj.onc.1207505 15064737
33. Danam RP Howell SR Brent TP Harris LC Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins Mol Cancer Ther 2005 4 61-69 15657354
34. Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity Curr Biol 2007 17 165-172 1855204 17196391 10.1016/j.cub.2006.11.033
35. Liu G Yuan X Zeng Z Tunici P Ng H Abdulkadir IR Lu L Irvin D Black KL Yu JS Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma Mol Cancer 2006 5 67 1697823 17140455 10.1186/ 1476-4598-5-67
36. Sasai K Romer JT Lee Y Finkelstein D Fuller C McKinnon PJ Curran T Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies Cancer Res 2006 66 4215-4222 10.1158/0008-5472.CAN-05-4505 16618744
37. Akagi T Murata K Shishido T Hanafusa H v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras Mol Cell Biol 2002 22 7015-7023 139810 12242282 10.1128/ MCB.22.20.7015-7023.2002