Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis

International Journal for Parasitology: Drugs and Drug Resistance

Volumn 4, Issue 3, 2014, Pages 256-266

  Morel, Marion ^a   Vanderstraete, Mathieu ^a   Cailliau, Katia ^a   Lescuyer, Arlette ^a   Lancelot, Julien ^a   Dissous, Colette ^a  

^a UNIV LILLE   (France)

Author keywords

Akt; Chemotherapy; Inhibitor; Protein kinase; Protein kinase B (PKB); Schistosoma mansoni

Indexed keywords

ANTISCHISTOSOMAL AGENT; GROWTH FACTOR; INSULIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SERINE; THREONINE; TYROSINE;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EGG LAYING; EGG PRODUCTION; ENZYME ACTIVITY; GONAD DEVELOPMENT; IN VITRO STUDY; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PARASITE SURVIVAL; PARASITE VIABILITY; PEPTIDE LIBRARY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMULUM; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; XENOPUS LAEVIS;

EID: 84916879551     PISSN: None     EISSN: 22113207     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2014.09.004     Document Type: Article

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