Developmental regulation of protein kinase A expression and activity in Schistosoma mansoni

International Journal for Parasitology

Volumn 40, Issue 8, 2010, Pages 929-935

  Swierczewski, Brett E ^a   Davies, Stephen J ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Blood fluke; Parasite development; Protein kinase A; Reproductive biology; Schistosoma mansoni; Schistosome

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PKI 14 22; PROTEIN KINASE A C; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); DEVELOPMENTAL STAGE; EGG PARASITOID; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; PARASITOLOGY; REPRODUCTIVE BIOLOGY; RNA; SCHISTOSOMIASIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; CELL VIABILITY; CERCARIA (TREMATODE LARVA); CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LARVAL STAGE; LETHALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANISMS BY LIFE CYCLE STAGE; PROTEIN EXPRESSION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; WORM;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; ISOQUINOLINES; MALE; MICE; MICE, INBRED C57BL; PROTEIN KINASE INHIBITORS; SCHISTOSOMA MANSONI; SULFONAMIDES; SURVIVAL ANALYSIS;

EUKARYOTA; MURINAE; SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMATIDAE;

EID: 77953028832     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2010.01.001     Document Type: Article

References (35)

1. Abel E.S., Davids B.J., Robles L.D., Loflin C.E., Gillin F.D., Chakrabarti R. Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia. J. Biol. Chem. 2001, 276:10320-10329.
2. Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
3. Amiri P., Locksley R.M., Parslow T.G., Sadick M., Rector E., Ritter D., McKerrow J.H. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature 1992, 356:604-607.
4. Basch P.F. Schistosomes: Development, Reproduction and Host Relations 1991, Oxford University Press, New York.
5. + T cells. J. Infect. Dis. 2006, 194:1609-1616.
6. Caffrey C.R. Chemotherapy of schistosomiasis: present and future. Curr. Opin. Chem. Biol. 2007, 11:433-439.
7. Cho-Chung Y.S., Nesterova M.V. Tumor reversion: protein kinase A isozyme switching. Ann. NY Acad. Sci. 2005, 1058:76-86.
8. Cho-Chung Y.S., Pepe S., Clair T., Budillon A., Nesterova M. cAMP-dependent protein kinase: role in normal and malignant growth. Crit. Rev. Oncol. Hematol. 1995, 21:33-61.
9. Cioli D., Pica-Mattoccia L. Praziquantel. Parasitol. Res. 2003, 90(Supp. 1):S3-S9.
10. Davies S.J., McKerrow J.H. Developmental plasticity in schistosomes and other helminths. Int. J. Parasitol. 2003, 33:1277-1284.
11. + lymphocytes. Science 2001, 294:1358-1361.
12. Dissous C., Ahier A., Khayath N. Protein tyrosine kinases as new potential targets against human schistosomiasis. Bioessays 2007, 29:1281-1288.
13. Doerig C. Protein kinases as targets for anti-parasitic chemotherapy. Biochim. Biophys. Acta 2004, 1697:155-168.
14. Engels D., Chitsulo L., Montresor A., Savioli L. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop. 2002, 82:139-146.
15. Fallon P.G., Doenhoff M.J. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am. J. Trop. Med. Hyg. 1994, 51:83-88.
16. Ismail M., Botros S., Metwally A., William S., Farghally A., Tao L.F., Day T.A., Bennett J.L. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am. J. Trop. Med. Hyg. 1999, 60:932-935.
17. 2+ in the regulation of miracidial transformation in Schistosoma mansoni. Parasitol. Res. 1989, 75:368-374.
18. Knobloch J., Kunz W., Grevelding C.G. Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni. Int. J. Parasitol. 2006, 36:1261-1272.
19. + T cell-dependent developmental mechanisms in the blood fluke pathogens of humans. Int. J. Parasitol. 2007, 37:405-415.
20. Lewis, F., 2001. Schistosomiasis. Curr. Protoc. Immunol. Chapter 19, Unit 19 11.
21. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
22. LoVerde P.T., Andrade L.F., Oliveira G. Signal transduction regulates schistosome reproductive biology. Curr. Opin. Microbiol. 2009, 12:422-428.
23. Matsuyama H., Takahashi H., Watanabe K., Fujimaki Y., Aoki Y. The involvement of cyclic adenosine monophosphate in the control of schistosome miracidium cilia. J. Parasitol. 2004, 90:8-14.
24. Melman S.D., Steinauer M.L., Cunningham C., Kubatko L.S., Mwangi I.N., Wynn N.B., Mutuku M.W., Karanja D.M., Colley D.G., Black C.L., Secor W.E., Mkoji G.M., Loker E.S. Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni. PLoS Negl. Trop. Dis. 2009, 3:e504.
25. Murray P., Clegg R.A., Rees H.H., Fisher M.J. siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans. Gene 2008, 408:157-163.
26. Popiel I., Basch P.F. Reproductive development of female Schistosoma mansoni (Digenea: Schistosomatidae) following bisexual pairing of worms and worm segments. J. Exp. Zool. 1984, 232:141-150.
27. Rual J.F., Ceron J., Koreth J., Hao T., Nicot A.S., Hirozane-Kishikawa T., Vandenhaute J., Orkin S.H., Hill D.E., van den Heuvel S., Vidal M. Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 2004, 14:2162-2168.
28. Saule P., Adriaenssens E., Delacre M., Chassande O., Bossu M., Auriault C., Wolowczuk I. Early variations of host thyroxine and interleukin-7 favor Schistosoma mansoni development. J. Parasitol. 2002, 88:849-855.
29. Siman-Tov M.M., Aly R., Shapira M., Jaffe C.L. Cloning from Leishmania major of a developmentally regulated gene, c-lpk2, for the catalytic subunit of the cAMP-dependent protein kinase. Mol. Biochem. Parasitol. 1996, 77:201-215.
30. Skalhegg B.S., Tasken K. Specificity in the cAMP/PKA signaling pathway, differential expression, regulation, and subcellular localization of subunits of PKA. Front. Biosci. 1997, 2:d331-d342.
31. Swierczewski B.E., Davies S.J. A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability. PLoS Negl. Trop. Dis. 2009, 3:e505.
32. Syin C., Parzy D., Traincard F., Boccaccio I., Joshi M.B., Lin D.T., Yang X.M., Assemat K., Doerig C., Langsley G. The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes. Eur. J. Biochem. 2001, 268:4842-4849.
33. Taylor S.S., Buechler J.A., Yonemoto W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 1990, 59:971-1005.
34. Taylor S.S., Kim C., Vigil D., Haste N.M., Yang J., Wu J., Anand G.S. Dynamics of signaling by PKA. Biochim. Biophys. Acta 2005, 1754:25-37.
35. Taylor S.S., Kim C., Cheng C.Y., Brown S.H., Wu J., Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim. Biophys. Acta 2008, 1784:16-26.