Thyroid hormone deiodinases D1, D2, and D3 are expressed in human endothelial dermal microvascular line: effects of thyroid hormones

Molecular and Cellular Biochemistry

Volumn 399, Issue 1-2, 2015, Pages 87-94

  Sabatino, Laura ^a   Lubrano, Valter ^b   Balzan, Silvana ^a   Kusmic, Claudia ^a   Del Turco, Serena ^a   Iervasi, Giorgio ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b FONDAZIONE TOSCANA GABRIELE MONASTERIO   (Italy)

Author keywords

Deiodinases; Endothelial cells; Thyroid hormones

Indexed keywords

3,3',5' TRIIODOTHYRONINE; ENZYME; LIOTHYRONINE; THYROID HORMONE; THYROID HORMONE DEIODINASE D1; THYROID HORMONE DEIODINASE D2; THYROID HORMONE DEIODINASE D3; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR ALPHA 1; THYROID HORMONE RECEPTOR ALPHA 2; THYROID HORMONE RECEPTOR BETA 1; THYROXINE; UNCLASSIFIED DRUG; IODIDE PEROXIDASE;

ANIMAL TISSUE; AORTA; ARTICLE; BRAIN TISSUE; CELL CULTURE; CONTROLLED STUDY; DERMAL MICROVASCULAR ENDOTHELIAL CELL; GENE EXPRESSION; HEART MUSCLE BIOPSY; HUMAN; HUMAN CELL; LIVER BIOPSY; NONHUMAN; RAT; TISSUE HOMOGENATE; WESTERN BLOTTING; CELL LINE; CYTOLOGY; DERMIS; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; METABOLISM; MICROVASCULATURE; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULARIZATION;

CELL LINE; DERMIS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; IODIDE PEROXIDASE; MICROVESSELS; RECEPTORS, THYROID HORMONE; THYROXINE; TRIIODOTHYRONINE;

EID: 84916641099     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2235-8     Document Type: Article

References (41)

1. Polikar R, Burger AG, Scherrer U, Nicod P (1993) The thyroid and the heart. Circulation 87:1435–1441
2. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38–89
3. Williams GR (2000) Cloning and characterization of two novel thyroid hormone receptor beta isoforms. Mol Cell Biol 20:8329–8342
4. Cheng SY, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31:139–170
5. Berry MJ, Banu L, Larsen PR (1991) Type I iodothyronine deiodinase is a selenocysteine containing enzyme. Nature 349:438–440
6. Mandel SJ, Berry MJ, Kieffer JD, Harney JW, Warne RL, Larsen PR (1992) Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab 75:1133–1139
7. Visser TJ, Kaptein E, Terpestra OT, Krenning EP (1988) Deiodination of thyroid hormone by human liver. J Clin Endocrinol Metab 67:17–24
8. Tu HM, Kim SW, Salvatore D, Bartha T, Legradi G, Larsen PR, Lechan RM (1997) Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 138:3359–3368
9. Sabatino L, Iervasi G, Ferrazzi P, Francesconi D, Chopra IJ (2000) A study of iodothyronine 5′-monodeiodinase activities in normal and pathological tissues in man and their comparison with activities in rat tissues. Life Sci 68:191–202
10. Sabatino L, Chopra IJ, Tanavoli S, Iacconi P, Iervasi G (2001) A radioimmunoassay for type I iodothyronine 5′-monodeiodinase in human tissues. Thyroid 11:733–739
11. Mori K, Stone S, Braverman LE, Devito WJ (1996) Involvement of tyrosine phosphorylation in the regulation of 5′-deiodinases in FRTL-5 rat thyroid cells and rat astrocytes. Endocrinology 137:1313–1318
12. Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC (2005) Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology 146:195–200
13. Huang SA, Dorfman DM, Genest DR, Salvatore D, Larsen PR (2003) Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab 88:1384–1388
14. Hang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewic HP, Mandel SJ, Larsen PR (2002) A 21 year old woman with consumptive hypothyroidism due to a vascular tumor ex pressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab 87:4457–4461
15. Haung SA, Tu HM, Harney LW, Venihaki M, Batte AJ, Kozakewic HP, Fishman SJ, Larsen PR (2000) Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 343:185–189
16. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ (1992) HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 99:683–690
17. Del Turco S, Basta G, Lazzerini G, Evangelista M, Rainaldi G, Tanganelli P, Camera M, Tremoli E, De Caterina R (2007) Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. Thromb Haemost 98:210–219
18. Esfandiari A, Courtin F, Lennon AM, Gavaret JM, Pierre M (1992) Induction of type III deiodinase activity in astroglial cells by thyroid hormones. Endocrinology 131:1682–1688
19. Pallud S, Ramaugè M, Gavaret JM, Lennon AM, Munsch N, St Germain DL, Pierre M, Courtin F (1999) Regulation of type 3 iodothyronine deiodinase expression in cultured rat astrocytes: role of the erk cascade. Endocrinology 140:2917–2923
20. Balzan S, Del Carratore R, Nicolini G, Beffy P, Lubrano V, Forini F, Iervasi G (2012) Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptor. J Clin Endocrinol Metab 97:1763–1770
21. Ojamaa K, Klemperer JD, Klein I (1996) Acute effects of thyroid hormone on vascular smooth muscle. Thyroid 6:505–512
22. Savinova OV, Liu Y, Aasen GA, Mao K, Weltman NY, Nedich BL, Liang Q, Gerdes AM (2011) Thyroid hormone promotes remodeling of coronary resistance vessels. PLoS One 6:e25054
23. Carrillo-Sepúlveda MA, Ceravolo GS, Fortes ZB, Carvalho MH, Tostes RC, Laurindo FR, Webb RC, Barreto-Chaves ML (2010) Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes. Cardiovasc Res 85:560–570
24. Napoli R, Guardasole V, Angelini V, Zarra E, terracino D, D’Anna C, Matarazzo M, Oliviero U, Macchia V, Saccà L (2007) Acute effects of triiodothyronine on endothelial function in human subjects. J Clin Endocrinol Metab 92:250–254
25. McAllister R, Grossenburg VD, Delp MD, Laughling H (1998) Effects of hyperthyroidism on vascular contractile responses. Am J Physiol 274:E946–E953
26. Berry MJ, Kates AL, Larsen PR (1990) Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol 4:743–748
27. Maia AL, Harney JW, Larsen PR (1995) Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways. Endocrinology 136:1488–1494
28. Wagner MS, Wajner SM, Dora JM, Maia AL (2007) Regulation of Dio2 gene expression by thyroid hormones in normal and type 1 deiodinase-deficient C3H mice. J Endocrinol 193:435–444
29. Richard K, Hume R, Kaptein E, Sanders JP, Van Toor H, De Herder WW, Den Hollander JC, Krenning EP, Visser TJ (1998) Ontogeny of iodothyronine deiodinases in human liver. J Clin Endocrinol Metab 83:2868–2874
30. Maia AL, Goemann IM, de Souza Meyer EL, Magagnin Wajner S (2011) Type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinology 209:283–297
31. Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR (2014) Thyroid hormones and skeletal muscle—new insights and potential implications. Nat Rev Endocrinol 10:206–214
32. St.Germain DL (1988) The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II. Endocrinology 122:1860–1868
33. Burmsteir LA, Pachucki J, St.Germain DL (1997) Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms. Endocrinology 138:5231–5237
34. Gereben B, Goncalves C, Harney JW, Larsen PR, Bianco AC (2000) Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol 14:1697–1708
35. Gereben B, Kollar A, Harney JW, Larsen PR (2002) The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Mol Endocrinol 16:1667–1679
36. Martinez-de Mena R, Hernandez A, Obregon MJ (2002) Triiodothyronine is required for the stimulation of type II 5′-deiodinase mRNA in rat brown adipocytes. Am J Physiol Endocrinol Metab 282:E1119–E1127
37. Steinsapir J, Bianco AC, Buettner C, Harney J, Larsen PR (2000) Substrate-induced down regulation of human type 2 deiodinase (hD2) is mediated through proteosomal degradation, requires interaction with the enzyme’s active center. Endocrinology 141:1127–1135
38. Steinsapir J, Harney J, Larsen PR (1998) Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest 102:1895–1899
39. St. Germain DL, Schwartzman RA, Croteau W, Kanamori A, Wang Z, Brown DD, Galton VA (1994) A thyroid hormone-regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase. Proc Natl Acad Sci USA 91:11282
40. Van der Geyten S, Buys N, Sanders JP, Decuypere E, Visser TJ, Kuhn ER, Darras VM (1999) Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos. Mol Cell Endocrinol 147:49–56
41. Kinugawa K, Yonekura K, Ribeiro RCJ, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, Simpson PC (2001) Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res 89:591–598