Inhaled corticosteroids in children with persistent asthma: Effects on growth

Evidence-Based Child Health

Volumn 9, Issue 4, 2014, Pages 829-930

  Zhang, Linjie ^a   Prietsch, Sílvio Om ^a   Ducharme, Francine M ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CICLESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; FLUNISOLIDE; FLUTICASONE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LONG ACTING DRUG; MOMETASONE FUROATE; MONTELUKAST; NEDOCROMIL; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; SALBUTAMOL; SALMETEROL; THEOPHYLLINE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BODY HEIGHT; CATCH UP GROWTH; CHILD; CHILD GROWTH; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; EVENING DOSAGE; FEMALE; FORCED EXPIRATORY VOLUME; GROWTH DISORDER; GROWTH RATE; HUMAN; INHALER; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; METERED DOSE INHALER; MILD PERSISTENT ASTHMA; MORNING DOSAGE; PATIENT COMPLIANCE; PEAK INSPIRATORY FLOW; PERSISTENT ASTHMA; PERSISTENT INFECTION; PHENOTYPE; PREPUBERTY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFLAMMATION; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TREATMENT DURATION;

EID: 84916640486     PISSN: 20404050     EISSN: 15576272     Source Type: Journal    
DOI: 10.1002/ebch.1988     Document Type: Article

References (103)

1. Allen DB, Bronsky EA, LaForce CF, Nathan RA, Tinkelman DG, Vandewalker ML, et al.Growth in asthmatic children treated with fluticasone propionate. Fluticasone Propionate Asthma Study Group. The Journal of Pediatrics 1998;132(3 Pt 1):472-7.
2. Becker AB, Kuznetsova O, Vermeulen J, Soto-Quiros ME, Young B, Reiss TF, et al.Linear growth in prepubertal asthmatic children treated with montelukast, beclomethasone, or placebo: a 56-week randomized double-blind study. Annals of Allergy, Asthma & Immunology 2006;96(6):800-7.
3. Bensch GW, Greos LS, Gawchik S, Kpamegan E, Newman KB. Linear growth and bone maturation are unaffected by 1 year of therapy with inhaled flunisolide hydrofluoroalkane in prepubescent children with mild persistent asthma: a randomized, double-blind, placebo-controlled trial. Annals of Allergy, Asthma & Immunology 2011;107(4):323-9.
4. Bisgaard H, Allen D, Milanowski J, Kalev I, Willits L, Davies P. Twelve-month safety and efficacy of Inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing. Pediatrics 2004;113:e87.
5. Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, et al.Effect of inhaled glucocorticoids in childhood on adult height. New England Journal of Medicine 2012;367:904-12.
6. The childhood asthma management program research group. Long-term effects of budesonide or nedocromil in children with asthma. The New England Journal of Medicine 2000;343(15):1054-63.
7. Doull I, Freezer N, Holgate S. Osteocalcin, growth, and inhaled corticosteroids: a prospective study. Archives of Disease in Childhood 1996;74:497-501.
8. Doull IJ, Freezer NJ, Holgate ST. Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. American Journal of Respirtory and Critical Care Medicine 1995;151(1):1715-9.
9. Gillman SA, Anolik R, Schenkel E, Newman K. One-year trial on safety and normal linear growth with flunisolide HFA in children with asthma. Clinical Pediatrics 2002;41(5):333-40.
10. Gradman J, Wolthers OD. A randomized trial of lower leg and height growth in children with asthma treated with inhaled budesonide from a new dry powder inhaler. Pediatric Allergy and Immunology 2010;21(1 Pt 2):e206-12.
11. Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, et al.Long-term inhaled corticosteroids in preschool children at high risk for asthma. The New England Journal of Medicine 2006;354(19):1985-97.
12. Jónasson G, Carlsen KH, Jonasson C, Mowinckel P. Low-dose inhaled budesonide once or twice daily for 27 months in children with mild asthma. Allergy 2000;55(8):740-8.
13. Kannisto S, Korppi M, Remes K, Voutilainen R. Adrenal suppression, evaluated by a low dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. The Journal of Clinical Endocrinology and Metabolism 2000;85(2):652-7.
14. Kannisto S, Voutilainen R, Remes K, Korppi M. Efficacy and safety of inhaled steroid and cromone treatment in school-age children: a randomized pragmatic pilot study. Pediatric Allergy and Immunology 2001;13:24-30.
15. Martinez FD, Chinchilli VM, Morgan WJ, Boehmer SJ, Lemanske RF Jr, Mauger DT, et al.Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet 2011;377(9766):650-7.
16. Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, et al.Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 2003;361(9363):1071-6.
17. Pedersen S, Potter P, Dachev S, Bosheva M, Kaczmarek J, Springer E, et al.Efficacy and safety of three ciclesonide doses vs placebo in children with asthma: the RAINBOW study. Respiratory Medicine 2010;104:1618-28.
18. Price JF, Russell G, Hindmarsh PC, Weller P, Heaf DP, Williams J. Growth during one year of treatment with fluticasone propionate or sodium cromoglycate in children with asthma. Pediatric Pulmonology 1997;24(3):178-86.
19. Roux C, Kolta S, Desfougères JL, Minini P, Bidat E. Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma. Pediatrics 2003;111(6 Pt 1):e706-13.
20. Simons FE. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. New England Journal of Medicine 1997;337(23):1659-65.
21. Skoner DP, Maspero J, Banerji D, Ciclesonide Pediatric Growth Study Group. Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma. Pediatrics 2008;121(1):e1-14.
22. Skoner DP, Meltzer EO, Milgrom H, Stryszak P, Teper A, Staudinger H. Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4-9 years old with mild persistent asthma. Journal of Asthma 2011;48(8):848-59.
23. Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD, et al.Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. Journal of Allergy and Clinical Immunology 2007;119(1):64-72.
24. Storr J, Lenney CA, Lenney W. Nebulised beclomethasone dipropionate in preschool asthma. Archives of Disease in Childhood 1986;61:270-3.
25. Tinkelman DG, Reed CE, Nelson HS, Offord KP. Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993;92(1):64-77.
26. Turpeinen M, Nikander K, Pelkonen AS, Syvänen P, Sorva R, Raitio H, et al.Daily versus as-needed inhaled corticosteroid for mild persistent asthma (the Helsinki early intervention childhood asthma study). Archives of Disease in Childhood 2008;93(8):654-9.
27. Verberne AA, Frost C, Roorda RJ, van der Laag H, Kerrebijn KF. One year treatment with salmeterol compared with beclomethasone in children with asthma. The Dutch Paediatric Asthma Study Group. American Journal of Respiratory and Critical Care Medicine 1997;156(3 Pt 1):688-95.
28. Wasserman RL, Baker JW, Kim KT, Blake KV, Scott CA, Wu W, et al.Efficacy and safety of inhaled fluticasone propionate chlorofluorocarbon in 2- to 4-year-old patients with asthma: results of a double-blind, placebo-controlled study. Annals of Allergy, Asthma & Immunology 2006;96(6):808-18.
29. Agertoft L, Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respiratory Medicine 1994;88:373-81.
30. Baxter-Jones AD, Helms PJ, Russell G, Grant A, Ross S, Cairns JA, et al.Early asthma prophylaxis, natural history, skeletal development and economy (EASE): a pilot randomised controlled trial. Health Technology Assessment 2000;4(28):1-89.
31. Brand PL, Luz García-García M, Morison A, Vermeulen JH, Weber HC. Ciclesonide in wheezy preschool children with a positive asthma predictive index or atopy. Respiratory Medicine 2011;105:1588-95.
32. CAMP Group. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Controlled Clinical Trials 1999;20(1):91-120.
33. Heuck C, Wolthers OD, Kollerup G, Hansen M, Teisner B. Adverse effects of inhaled budesonide (800 micrograms) on growth and collagen turnover in children with asthma: a double-blind comparison of once-daily versus twice-daily administration. Journal of Pediatrics 1998;133(5):608-12.
34. Kerrebijn KF. Beclomethasone dipropionate in long-term treatment of asthma in children. Journal of Pediatrics 1976;89(5):821-6.
35. Martinati LC, Bertoldo F, Gasperi E, Fortunati P, Lo Cascio V, Boner AL. Longitudinal evaluation of bone mass in asthmatic children treated with inhaled beclomethasone dipropionate or cromolyn sodium. Allergy 1998;53:705-8.
36. Merkus PJ, van Essen-Zandvliet EE, Duiverman EJ, van Houwelingen HC, Kerrebijn KF, Quanjer PH. Long-term effect of inhaled corticosteroids on growth rate in adolescents with asthma. Pediatrics 1993;91(6):1121-6.
37. Rao R, Gregson RK, Jones AC, Miles EA, Campbell MJ, Warner JO. Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone with beclomethasone. European Respiratory Journal 1999;13(1):87-94.
38. Teper AM, Colom AJ, Kofman CD, Maffey AF, Vidaurreta SM, Bergadá I. Effects of inhaled fluticasone propionate in children less than 2 years old with recurrent wheezing. Pediatric Pulmonology 2004;37:111-5.
39. Tinkelman D. Theophylline therapy for children with asthma. European Respiratory Review 1996;6(34):79-83.
40. Verberne AA, Frost C, Duiverman EJ, Grol MH, Kerrebijn KF. Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma. The Dutch Asthma Study Group. American Journal of Respiratory and Critical Care Medicine 1998;158(1):213-9.
41. Xu Z, Chen HY, Zhang SY, Wang XL, He CR, Qiao YX. Efficacy and safety of corticosteroid inhalation in the treatment of childhood asthma. Chinese Journal of Contemporary Pediatrics 2005;7(1):47-50.
42. Adams NP, Bestall JC, Lasserson TJ, Jones P, Cates CJ. Fluticasone versus placebo for chronic asthma in adults and children. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD003135.pub4]
43. Adams NP, Bestall JB, Malouf R, Lasserson TJ, Jones PW. Beclomethasone versus placebo for chronic asthma. Cochrane Database of Systematic Reviews 2005, Issue 1. [DOI: 10.1002/14651858.CD002738.pub2]
44. Adams NP, Bestall JB, Jones PW. Budesonide versus placebo for chronic asthma in children and adults. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD003274]
45. Agertoft L, Pedersen S. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. New England Journal of Medicine 2000;343:1064-9.
46. Allen DB, Mullen M, Mullen B. A meta-analysis of the effect of oral and inhaled corticosteroids on growth. Journal of Allergy and Clinical Immunology 1994;93(6):967-76.
47. Allen DB. Limitations of short-term studies in predicting long-term adverse effects of inhaled corticosteroids. Allergy 1999;54:29-34.
48. Allen DB. Safety of inhaled corticosteroids in children. Pediatric Pulmonology 2002;33:208-20.
49. Allen DB. Effects of inhaled steroids on growth, bone metabolism, and adrenal function. Advances in Pediatrics 2006;53:101-10.
50. Asher MI. Recent perspectives on global epidemiology of asthma in childhood. Allergologia et Immunopathologia 2010;38(2):83-7.
51. Inge A, Prietsch SOM, Zhang L. Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth. Cochrane Database of Systematic Reviews 2012, Issue 10. [DOI: 10.1002/14651858.CD010126]
52. Barnes PJ. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. British Journal of Pharmacology 2006;148(3):245-54.
53. Braman SS. The global burden of asthma. Chest 2006;130:4S-12S.
54. Brand PLP. Inhaled corticosteroids reduce growth. Or do they?. European Respiratory Journal 2001;17:287-94.
55. British Thoracic Society and Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. http://www.brit-thoracic.org.uk/Portals/0/Guidelines/AsthmaGuidelines/sign101%20Jan%202012.pdf. (accessed 26 April 2013).
56. Bush A. Phenotype specific treatment of asthma in children. Paediatric Respiratory Reviews 2004;5(Supplement 1):S93-S101.
57. Busse WW, Lemanske RF. Asthma. New England Journal of Medicine 2001;344(5):350-62.
58. Carlsen 2002
59. Carlsen KH, Gerritsen J. Inhaled steroids in children: adrenal suppression and growth impairment. European Respiratory Journal 2002;19:985-8.
60. Chauhan BF, Chartrand C, Ducharme FM. Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults. Cochrane Database of Systematic Reviews 2013, Issue 2. [DOI: 10.1002/14651858.CD009611.pub3]
61. Colice GL. Comparing inhaled corticosteroids. Respiratory Care 2000;45(7):846-53.
62. Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J, et al.Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. Journal of Pediatrics 2003;142(5):469-75.
63. Creese KH, Doull IJ. Effects of inhaled corticosteroids on growth in asthmatic children. Current Allergy and Asthma Reports 2001;1(2):122-6.
64. Djukanović R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, et al.Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. American Review of Respiratory Disease 1992;145(3):669-74.
65. Efthimiou J, Barnes PJ. Effect of inhaled corticosteroids on bones and growth. European Respiratory Journal 1998;11:1167-77.
66. US Food, Drug Administration (FDA). FDA requires new pediatric labelling for inhaled, intranasal corticosteroids. FDA Talk Paper November 9, 1998.
67. FDA . Guidance for Industry. Orally inhaled and intranasal corticosteroids: evaluation of the effects on growth in children. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071968.pdf (accessed 16 December 2013).
68. Ferguson AC, Spier S, Manjra A, Versteegh FG, Mark S, Zhang P. Efficacy and safety of high-dose inhaled steroids in children with asthma: a comparison of fluticasone propionate with budesonide. Journal of Pediatrics 1999;134(4):422-7.
69. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention 2012 (update). www.ginasthma.com.org (accessed 22 April 2012).
70. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention, revised 2014. www.ginasthma.com.org (accessed 01 May 2014).
71. Hedlin G, Ingemansson M, Brännegord M, Marcus C, Stierna P. A study of children with asthma treated with inhaled corticosteroids (ICS) with or without growth retardation. Journal of Allergy and Clinical Immunology 1998;101:S13.
72. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analysis. BMJ 2003;327:557-60.
73. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org, 2011.
74. Hoekx JCM, Hedlin G, Pedersen W, Sorva R, Hollingworth K, Efthimiou J. Fluticasone propionate compared with budesonide: a double-blind trial in asthmatic children using powder devices at a dosage of 400 μg/day. European Respiratory Journal 1996;9:2263-72.
75. Hogger P. Dose response and therapeutic index of inhaled corticosteroids in asthma. Current Opinion in Pulmonary Medicine 2003;9:1-8.
76. ISAAC Steering Committee. Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC). European Respiratory Journal 1998;12:315-35.
77. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'Byrne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. American Review of Respiratory Disease 1990;142(4):832-6.
78. Karlberg J, Gelander L, Albertsson-Wikland K. Distinctions between short- and long-term human growth studies. Acta Paediatrics 1994;83:777-8.
79. Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, et al.Effect of inhaled glucocorticoids in childhood on adult height. New England Journal of Medicine 2012;367(10):904-12.
80. Lai C, Beasley R, Crane J, Foliaki S, Shah J, Weiland S. Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009;64(6):476-83.
81. Leung DY, Bloom JW. Update on glucocorticoid action and resistance. Journal of Allergy and Clinical Immunology 2003;111(1):3-22.
82. Lougheed MD, Lemiere C, Ducharme FM, Licskai C, Del SD, Rowe BH, et al.Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults. Canadian Respiratory Journal 2012;19(2):127-64.
83. Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59(5):469-78.
84. National Heart Lung and Blood Institute. Guidelines for the diagnosis and management of asthma (EPR-3). www.nhlbi.nih.gov/guidelines/asthma (accessed 20 June 2011).
85. Olivieri D, Chetta A, Del Donno M, Bertorelli G, Casalini A, Pesci A, et al.Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. American Journal of Respiratory and Critical Care Medicine 1997;155(6):1864-71.
86. Pedersen S. Do inhaled corticosteroids inhibit growth in children?. Americian Journal of Respiratory and Critical Care Medicine 2001;164(4):521-35.
87. Price J, Hindmarsh P, Hughes S, Efthimiou J. Evaluating the effects of asthma therapy on childhood growth: what can be learnt from the published literature?. European Respiratory Journal 2002;19:1179-93.
88. Pruteanu A, Chauhan BF, Zhang L, Prietsch SOM, Ducharme FM. Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth. Cochrane Database of Systematic Reviews In press. [: 10.1002/14651858.CD009878]
89. Copenhagen, The Nordic Cochrane Centre: The Cochrane Collaboration. Review Manager (RevMan) Version 5.0. Copenhagen, The Nordic Cochrane Centre: The Cochrane Collaboration, 2008.
90. Salvatoni A, Piantanida E, Nosetti L, Nespoli L. Inhaled corticosteroids in childhood asthma: long-term effects on growth and adrenocortical function. Paediatric Drugs 2003;5(6):351-61.
91. Sharek PJ, Bergman D, Francine D. Beclomethasone for asthma in children: effects on linear growth. Cochrane Database of Systematic Reviews 2000, Issue 2. [DOI: 10.1002/14651858.CD001282]
92. Sharek PJ, Bergman DA. The effect of inhaled steroids on the linear growth of children with asthma: a meta-analysis. Pediatrics 2000;106:e8.
93. Sizonenko PC. Effects of inhaled or nasal glucocorticosteroids on adrenal function and growth. Journal of Pediatric Endocrinology and Metabolism 2002;15(1):5-26.
94. Sobande PO, Kercsmar CM. Inhaled corticosteroids in asthma management. Respiratory Care 2008;53(5):625-33.
95. Stein RT, Martinez FD. Asthma phenotypes in childhood: lessons from epidemiological approach. Paediatric Respiratory Reviews 2004;5(2):155-61.
96. Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. New England Journal of Medicine 2000;343(5):332-6.
97. Van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, Duiverman EJ, Pocock SJ, Kerrebijn KF. Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. The Dutch Chronic Non-specific Lung Disease Study Group. American Review of Respiratory Disease 1992;146(3):547-54.
98. Van Rensen EL, Straathof KC, Veselic-Charvat MA, Zwinderman AH, Bel EH, Sterk PJ. Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma. Thorax 1999;54(5):403-8.
99. Witzmann KB, Fink RJ. Inhaled corticosteroids in childhood asthma: growing concerns. Drugs.2000;59 2000;59(Suppl 1):9-14.
100. Wolthers OD, Pedersen S. Short-term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Archives of Disease in Childhood 1993;68(5):673-6.
101. Wolthers O, Hansen M, Juul A, Nielsen HK, Pedersen S. Knemometry, urine cortisol excretion and measures of the insulin-like growth factor axis and collagen turnover in the assessment of systemic activity of inhaled corticosteroids. Pediatric Research 1997;41:44-50.
102. Wolthers OD. Inhaled corticosteroids and growth. Journal of Pediatric Endocrinology and Metabolism 2001;14(Suppl 6):1487-90.
103. Yiallouros PK, Milner AD, Conway E, Honour JW. Adrenal function and high dose inhaled corticosteroids for asthma. Archives of Disease in Childhood 1997;76:405-10.