Effects of inhaled corticosteroids on growth in asthmatic children

Current Allergy and Asthma Reports

Volumn 1, Issue 2, 2001, Pages 122-126

  Creese, Katherine H ^a   Doull, Iolo J M ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Asthma; Asthmatic Child; Budesonide; Fluticasone Propionate; Salmeterol

Indexed keywords

CORTICOSTEROID;

ADOLESCENT; ASTHMA; CHILD; CHILD WELFARE; DOSE RESPONSE; DRUG EFFECT; GROWTH; HUMAN; INHALATIONAL DRUG ADMINISTRATION; REVIEW; TIME; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENAL CORTEX HORMONES; ASTHMA; CHILD; CHILD WELFARE; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH; HUMANS; TIME FACTORS; TREATMENT OUTCOME;

EID: 0035295779     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-001-0079-2     Document Type: Article

References (36)

1. Pierrepoint MJ, Doull IJM: Inflammation in asthma: the basis for rational therapy. Curr Paediatr 2000, 10:145–149. DOI: 10.1054/cupe.2000.0116
2. Van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, et al.: Effects of 22 months of treatment with inhaled corticosteroids and/or beta 2 agonists on lung function, airway responsiveness and symptoms in children with asthma. Am Rev Respir Dis 1992, 146:547–554.
3. Warner JO: Review of prescribed treatment for children with asthma in 1990. BMJ 1995, 311:663–666.
4. Tinkelman DG, Reed CE, Nelson HS, Offord KP: Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993, 92:64–77.
5. Doull IJM, Freezer NJ, Holgate ST: Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Resp Crit Care Med 1995, 151:1715–1719.
6. Verberne AA, Frost C, Roorda RJ, et al.: One year treatment with salmeterol compared with beclomethasone in children with asthma. Am J Resp Crit Care Med 1997, 156:688–695.
7. Simons FER, Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group: A comparison of beclomethasone, salmeterol and placebo in children with asthma. N Engl J Med 1997, 337:1659–1665. DOI: 10.1056/NEJM199712043372304
8. Allen DB, Bronsky EA, LaForce CF, et al.: Growth in asthmatic children treated with fluticasone propionate. J Pediatr 1998, 132:472–477. DOI: 10.1016/S0022-3476(98)70023-X
9. The Childhood Asthma Management Program Research Group: Long term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000, 343:1054–1063. This 4- to 6-year comparison of BUD, nedocromil, and placebo demonstrated that growth while receiving budesonide is decreased in the 1st year but normal thereafter. DOI: 10.1056/NEJM200010123431501
10. Cohen MB, Welles RR, Cohen S: Anthropometry in children: progress in allergic children as shown by increments in height, weight and maturity. Am J Dis Child 1940, 60:1058–1066.
11. Spock A: Growth patterns in 200 children with bronchial asthma. Ann Allergy 1965, 23:608–615.
12. Kerrebijn KF, De Kroon JPM: Effect on height of corticosteroid therapy in asthmatic children. Arch Dis Child 1968, 43:556–561.
13. Godfrey S, König P: Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol. Arch Dis Child 1974, 49:591–596.
14. Francis RS: Long term beclomethasone dipropionate aerosol therapy in juvenile asthma. Thorax 1976, 31:309–314.
15. Godfrey S, Balfour-Lynn L, Tolley M: A three to five year follow up of the use of the aerosol steroid beclomethasone dipropionate in childhood asthma. J Allergy Clin Immunol 1978, 62:335–339. DOI: 10.1016/0091-6749(78)90133-1
16. Graff-Lonnevig V, Kraepelien S: Long term treatment with Beclomethasone Dipropionate aerosol in asthmatic children with special reference to growth. Allergy 1979, 34:57–61. DOI: 10.1111/j.1398-9995.1979.tb02001.x
17. Littlewood JM, Johnson AW, Edwards PA, Littlewood AE: Growth retardation in asthmatic children treated with inhaled beclomethasone dipropionate. Lancet 1988, 1:115–116. DOI: 10.1016/S0140-6736(88)90310-8
18. Hauspie RC, Gyenis G, Alexander F, et al.: Heights and weights of Hungarian and Belgian boys. Hum Biol 1979, 51:507–521.
19. Ferguson AC, Murray AB, Wah-Jun T: Short stature and delayed skeletal maturation in children with allergic disease. J Allergy Clin Immunol 1982, 69:461–466. DOI: 10.1016/0091-6749(82)90122-1
20. Martin AJ, Landau LI, Phelan PD: The effect of growth on childhood asthma. Acta Paediatr Scand 1981, 70:683–688.
21. Balfour-Lynn L: Growth and childhood asthma. Arch Dis Child 1986, 61:1049–1055.
22. Shohat M, Shohat T, Kedem R, et al.: Childhood asthma and growth outcome. Arch Dis Child 1987, 62:63–65.
23. Wolthers OD, Pedersen S: Short term linear growth in asthmatic children during treatment with prednisolone. BMJ 1990, 301:145–148.
24. Wolthers O, Pedersen S: Growth of asthmatic children during treatment with budesonide: a double blind trial. BMJ 1991, 303:163–165.
25. Wolthers O, Pedersen S: Controlled study of linear growth in asthmatic children during treatment with inhaled glucocorticosteroids. Pediatrics 1992, 89:839–842.
26. MacKenzie CA, Wales JK: Growth of asthmatic children. BMJ 1991, 303:416.
27. Wolthers O, Pedersen S: Short term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Arch Dis Child 1993, 68:673–676.
28. Agertoft L, Pedersen S: Short term knemometry and urine cortisol excretion in children treated with fluticasone propionate and budesonide: a dose response study. Eur Respir J 1997, 10:1507–1512. DOI: 10.1183/09031936.97.10071507
29. Visser MJ, van Aalderen WM, Elliott BM, et al.: Short term growth in asthmatic children using fluticasone propionate. Chest 1998, 113:584–586.
30. Hermanussen M, Burmeister J: Standards for the predictive accuracy of short term body height and lower leg length measurement on half annual growth rates. Arch Dis Child 1989, 64:259–263. DOI: 10.1136/adc.64.2.259
31. Doull IJM, Campbell MJ, Holgate ST: Duration of growth suppressive effects of regular inhaled corticosteroids. Arch Dis Child 1997, 78:172–173.
32. Sharek PJ, Bergman DA: The effect of inhaled steroids on the linear growth of children with asthma: a meta-analysis. Pediatrics 2000, 106:E8. This meta-analysis demonstrated that BDP decreases growth by 1.5 cm/y. DOI: 10.1542/peds.106.1.e8
33. Rao R, Gregson RK, Jones AC, et al.: Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone and beclomethasone. Eur Respir J 1990, 13:87–94.
34. Agertoft L, Pedersen S: Effect of long term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 2000, 343:1064–1069. In this longitudinal follow-up of over 300 children, BUD caused decreased growth when initiated, but there were no long-term effects on growth, and attained adult height was normal. DOI: 10.1056/NEJM200010123431502
35. Crowley S, Hindmarsh PC, Mathews DR, Brook CGD: Growth and the growth hormone axis in prepubertal children with asthma. J Pediatr 1995, 126:297–303. DOI: 10.1016/S0022-3476(95)70566-X
36. Wolthers OD, Hansen M, Juul A, et al.: Knemometry, urine cortisol excretion, and measures of the insulin-like growth factor axis and collagen turnover in children treated with inhaled glucocorticosteroids. Pediatr Res 1997, 41:44–50. DOI: 10.1203/00006450-199701000-00007