Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat

Iranian Journal of Basic Medical Sciences

Volumn 17, Issue 11, 2014, Pages 895-902

  Sarshoori, Javad Raouf ^a   Asadi, Mohammad Hossien ^a   Mohammadi, Mohammad Taghi ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocin; Histopathological changes; Ischemia reperfusion injury; Neuroprotection

Indexed keywords

CROCIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXON DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DEMYELINATION; EDEMA; EOSINOPHILIC NEURON; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NERVE INJURY; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY; RIGHTING REFLEX; SCORING SYSTEM;

RATTUS;

EID: 84916636458     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage. Neuropharmacology 2008; 55:310-318.
2. Petito CK, Feldmann E, Pulsinelli WA, Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 1987; 37:1281-1216. 1987
3. Pantoni L, Garcia JH, Gutierrez JA. Cerebral white matter is highly vulnerable to ischemia. Stroke 1996; 27:1641-1646.
4. Tanaka K, Nogawa S, Ito D, Suzuki S, Dembo T, Kosakai A, et al. Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain. Neuroreport 2001; 12:2169-2174.
5. Garcia JH, Liu KF, Ye ZR, Gutierrez JA. Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats. Stroke 1997; 28:2303-2329.
6. DeGirolami U, Crowell RM, Marcoux FW. Selective necrosis and total necrosis in focal cerebral ischemia. Neuropathologic observations on experimental middle cerebral artery occlusion in the macaque monkey. J Neuropathol Exp Neurol 1984; 43:57-71.
7. Margaritescu O, Mogoanta L, Pirici I, Pirici D, Cernea D, Margaritescu C. Histopathological changes in acute ischemic stroke. Rom J Morphol Embryol 2009; 50:327-339.
8. Slujitoru AS, Enache AL, Pintea IL, Rolea E, Stocheci CM, Pop OT, et al. Clinical and morphological correlations in acute ischemic stroke. Rom J Morphol Embryol 2012; 53:917-926.
9. Gholamnezhad Z, Koushyar H, Byrami G, Boskabady MH. The extract of crocus sativus and its constituent dsfranal, affect serum levels of endothelin and total protein in sensitized guinea pigs. Iran J Basic Med Sci 2013; 16:1022-1026.
10. Tamaddonfard E, Farshid AA, Ahmadian E, Hamidhoseyni A. Crocin enhanced functional recovery after sciatic nerve crush injury in rats. Iran J Basic Med Sci 2013; 16:83-90.
11. Abdullaev FI. Biological effects of saffron. Biofactors 1993; 4:83-86.
12. Tamaddonfard E, Farshid AA, Asri-Rezaee S, Javadi S, Khosravi V, Rahman B, et al. Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats. Iran J Basic Med Sci 2013; 16:91-100.
13. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 2012; 32:227-235.
14. Deslauriers AM, Afkhami-Goli A, Paul AM, Bhat RK, Acharjee S, Ellestad KK, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration. J Immunol 2011; 187:4788-4799.
15. Imenshahidi M, Razavi BM, Faal A, Gholampoor A, Mousavi SM, Hosseinzadeh H. Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. Iran J Basic Med Sci 2014; 17:9-13.
16. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci 2013; 16:64-72.
17. Ochiai T, Ohno S, Soeda S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci Lett 2004; 362:61-64.
18. Laabich A, Vissvesvaran GP, Lieu KL, Murata K, McGinn TE, Manmoto CC, et al. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol Vis Sci 2006; 47:3156-3163.
19. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005; 8:387-393.
20. Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med 2009; 6:343-350.
21. Vakili A, Einali MR, Bandegi AR. Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke. J Stroke Cerebrovasc Dis 2014; 23:106-113.
22. Zheng Y-Q, Liu J-X, Wang J-N, Xu L. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007; 1138:86-94.
23. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20:84-91.
24. Plesnila N, Zinkel S, Le DA, Amin-Hanjani S, Wu Y, Qiu J, et al. BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A 2001; 98:15318-15323.
25. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990; 10:290-293.
26. Zarei Jaliani H, Riazi GH, Ghaffari SM, Karima O, Rahmani A. The effect of the Crocus sativus L.Carotenoid, crocin, on the polymerization of microtubules, in vitro. Iran J Basic Med Sci 2013; 16:101-107.
27. Nam KN, Park Y-M, Jung H-J, Lee JY, Min BD, Park S-U, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol 2010; 648:110-116.
28. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010; 4:118-126.
29. Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H, et al. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 2011; 14:1505-1517.
30. Oh SM, Betz AL. Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats. Stroke 1991; 22:915-921.
31. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 2007; 1770:578-584.
32. Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007; 6:258-268.
33. Gu Y, Dee CM, Shen J. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. Front Biosci 2011; 3:1216-1231.
34. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, et al. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 2002; 297:1186-1190.
35. Mena H, Cadavid D, Rushing E. Human cerebral infarct: a proposed histopathologic classification based on 137 cases. Acta Neuropathologica 200; 84:524-530.
36. Garman RH. Histology of the central nervous system. Toxicol Pathol 2011; 39:22-35.
37. Mohammadi MT, Amini R, Jahanbakhsh Z, Shekarforoush S. Effects of atorvastatin on the hypertension-induced oxidative stress in the rat brain. Iran Biomed J 2013; 17:152-157.
38. Su KG, Banker G, Bourdette D, Forte M. Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep 2009; 9:411-417.
39. Jun-li H, Hai-ning Z, Wei-ping L, Xiao-sheng HE, Zhou FEI. Neuroprotective Effects of crocin against traumatic brain injury in mice. Progress in modern biomedicine 2013;10:1892-1894.
40. Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol 2010; 648:110-116.