The effect of the Crocus Sativus L. Carotenoid, Crocin, on the polymerization of microtubules, in vitro

Iranian Journal of Basic Medical Sciences

Volumn 16, Issue 1, 2013, Pages 101-107

  Jaliani, Hossein Zarei ^a   Riazi, Gholam Hossein ^a   Ghaffari, Seyyed Mahmoud ^a   Karima, Oveis ^a   Rahmani, Abbas ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Carotenoid; Fluorescence spectroscopy; Microtubules; Tubulin

Indexed keywords

CAROTENOID; CROCIN; MICROTUBULE PROTEIN; PACLITAXEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; FLUORESCENCE SPECTROSCOPY; IN VITRO STUDY; MICROTUBULE ASSEMBLY; NONHUMAN; PROTEIN INTERACTION; PROTEIN PURIFICATION; SHEEP; TURBIDIMETRY; ULTRAVIOLET SPECTROSCOPY;

CROCUS SATIVUS; OVIS ARIES;

EID: 84872876231     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Abdullaev FI. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med (Maywood) 2002; 227:20-25.
2. Nair SC, Pannikar B, Panikkar KR. Antitumour activity of saffron (Crocus sativus). Cancer Lett 1991; 57:109-114.
3. Tarantilis PA, Morjani H, Polissiou M, Manfait M. Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res 1994; 14:1913-1918.
4. Chryssanthi DG, Lamari FN, Iatrou G, Pylara A, Karamanos NK, Cordopatis P. Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res 2007; 7:357-362.
5. Zhao P, Luo CL, Wu XH, Hu HB, Lv CF, Ji HY. [Proliferation apoptotic influence of crocin on human bladder cancer T24 cell line]. Zhongguo Zhong Yao Za Zhi 2008; 33:1869-1873.
6. Dhar A, Mehta S, Dhar G, Dhar K, Banerjee S, Van VP, et al. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 2009; 8:315-323.
7. Premkumar K, Thirunavukkarasu C, Abraham SK, Santhiya ST, Ramesh A. Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum Exp Toxicol 2006; 25:79-84.
8. Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, et al. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 2007; 29:175-180.
9. Abdullaev FI, Frenkel GD. The effect of saffron on intracellular DNA, RNA and protein synthesis in malignant and non-malignant human cells. Biofactors 1992; 4:43-45.
10. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 1996; 100:23-30.
11. Abdullaev JF, Caballero-Ortega H, Riveron-Negrete L, Pereda-Miranda R, Rivera-Luna R, Manuel HJ, et al. [In vitro evaluation of the chemopreventive potential of saffron]. Rev Invest Clin 2002; 54:430-436.
12. McKeithan TW, Rosenbaum JL. The biochemistry of microtubules. A review. Cell Muscle Motil 1984; 5:255-288.
13. Snyder JA, McIntosh JR. Biochemistry and physiology of microtubules. Annu Rev Biochem 1976; 45:699-720.
14. Dumontet C, Jordan MA. Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov 2010; 9:790-803.
15. Yue QX, Liu X, Guo DA. Microtubule-binding natural products for cancer therapy. Planta Med 2010; 76:1037-1043.
16. Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW. A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA 1975; 72:1858-1862.
17. Weinert T, Cappuccinelli P, Wiche G. Potent microtubule inhibitor protein from dictyostelium discoideum. Biochemistry 1982; 21:782-789.
18. Dubikovskaya EA, Thorne SH, Pillow TH, Contag CH, Wender PA. Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters. Proc Natl Acad Sci USA 2008; 105:12128-12133.
19. Zhou J, Panda D, Landen JW, Wilson L, Joshi HC. Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J Biol Chem 2002; 277:17200-1728.
20. Gheshlaghi ZN, Riazi GH, Ahmadian S, Ghafari M, Mahinpour R. Toxicity and interaction of titanium dioxide nanoparticles with microtubule protein. Acta Biochim Biophys Sin (Shanghai) 2008; 40:777-782.
21. Solomaha E, Palfrey HC. Conformational changes in dynamin on GTP binding and oligomerization reported by intrinsic and extrinsic fluorescence. Biochem J 2005; 391:601-611.