Crocin enhanced functional recovery after sciatic nerve crush injury in rats

Iranian Journal of Basic Medical Sciences

Volumn 16, Issue 1, 2013, Pages 83-90

  Tamaddonfard, Esmaeal ^a   Farshid, Amir Abbas ^a   Ahmadian, Elham ^a   Hamidhoseyni, Abbas ^a  

^a URMIA UNIVERSITY   (Iran)

Author keywords

Crocin; Crush injury; Functional recovery; Rats; Sciatic nerve

Indexed keywords

CROCIN; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; HISTOPATHOLOGY; MALE; NERVE CRUSH; NERVE DEGENERATION; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; RAT; SCIATIC NERVE INJURY;

RATTUS; RATTUS NORVEGICUS; WALLERIA;

EID: 84872848853     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Stoll G, Muller HW. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol 1999; 9:313-325.
2. Redriguez FJ, Valero-cabre A, Navarro X. Regeneration and functional recovery following peripheral nerve injury. Drug Discov Today: Dis Models 2004; 1:177-185.
3. Rotshenker S. Wallerian degeneration: the innate-immune response to traumatic nerve injury. J Neuroinflammation 2011; 8:109.
4. Coban YK, Ciralik H, Kurulas EB. Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rats. J Brachial Plex Peripher Nerve Inj 2006; 1:2.
5. Senoglu M, Nacitarhan V, Kurutas EB, Senoglu N, Altun I, Atli Y, et al. Intraperitoneal alpha-lipoic acid to prevent neural damage after crush injury to the rat sciatic nerve. J Brachial Plex Peripher Nerve Inj 2009; 4:22.
6. Lee IA, Lee JH, Baek NI, Kim DH. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin. Biol Pharm Bull 2005; 28:2106-2110.
7. Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, et al. Crocin from Crocus sativus possesses significant anti-prolifration effects on human colorectal cancer cells. Exp Oncol 2007; 29:175-180.
8. Xu GL, Li G, Ma HP, Zhong H, Liu F, Ao GZ. Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells. Agric Food Chem 2009; 57:8325-8330.
9. Tamaddonfard E, Hamzeh-Gooshchi N. Effect of crocin on the morphine-induced antinociception in the formalin test in rats. Phytother Res 2010; 24:410-413.
10. Tamaddonfard E, Hamzeh-Gooshchi N. Effects of intraperitoneal and intracerebroventricular injection of crocin on acute corneal pain in rats. Phytother Res 2010; 24:1463-1467.
11. Tamaddonfard E, Hamzeh-Gooshchi N, Seiednejhad-Yamchi S. Central effect of crocin on penicillin-induced epileptiform activity in rats. Pharmacol Rep 2012; 64:94-101.
12. Tamaddonfard E, Farshid AA, Hosseini L. Crocin alleviates the local paw edema induced by histamine in rats. Avicenna J Phytomed 2012; 2:97-104.
13. Asdaq SM, Inamdar MN. Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 2010; 162:358-372.
14. Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol 2010; 648:110-116.
15. Zheng YQ, Liu X, Wang JN, Xu L. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007; 1138:86-94.
16. Deslauriers AM, Afkhami-Gli A, Paul AM, Bhat RK, Acharjee S, Ellestad KK, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration. J Immunol 2011; 187:4788-4799.
17. Zarei Jaliani H, Riazi GH, Ghaffari SM, Kariman O, Rahmani A. The effect of the Crocus sativus L. carotenoid, crocin, on the polymerization of microtubules, in vitro. Iran J Basic Med Sci 2012; 15: (In Press)
18. Goyal SN, Arora S, Sharma AK, Joshi S, Ray R, Bhatia J, et al. Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastructural alternations in isoproterenol-induced cardiotoxicity in rats. Phytomedicine 2010; 17:227-232.
19. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol 2011; 667:222-229.
20. Hariri AT, Moallem SA, Mahmodi M, Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine 2011; 18:499-504.
21. Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 1989; 83:129-138.
22. Ohkawa H, Ohishi N, Yagi N. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358.
23. Gudemez E, Ozer K, Cunningham B, Siemionow K, Brownw E, Siemionow M. Dehydroepiandrosterone as an enhancer of functional recovery following crush injury to rat sciatic nerve. Microsurgery 2002; 22:234-241.
24. Oliveira EF, Mazzer N, Barbieri CH, Selli M. Correlation between functional index and morphometry to evaluate recovery of the rat sciatic nerve following crush injury: experimental study. J Reconstr Microsurg 2001; 17:69-75.
25. Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt K, Hunter DA, et al. Nerve crush injuries - a model for axonotmesis. Exp Neurol 1994; 127:284-290.
26. Xavier AM, Serafim KG, Higashi DT, Vanat N, Flaiban KK, Siqueira CP, et al. Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats. Injury 2012; 43:584-289.
27. Rempel D, Dahlin L, Lundberg G. Pathophysiology of nerve compression syndromes: response of peripheral nerves to loading. J Bone Joint Surg AM 1999; 81:1600-1610.
28. Mazzer PY, Barbieri CH, Mazzer N, Fazan VP. Morphologic and morphometric evaluation of experimental acute crush injuries of the sciatic nerve of rats. J Neurosci Methods 2008; 173: 249-258.
29. Serarslan Y, Bal R, Altug ME, Kontas T, Unal D, Unal B. Effects of trimetazudine on crush injury of the sciatic nerve in rats: a biochemical and stereological study. Brain Res 2009; 1247: 11-20.
30. Bagdatoglu C, Sarray A, Surucu HS, Ozturk H, Tamer L.Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. Neurosurgery 2002; 51:212-220.
31. Moore K, Roberts LJ. Measurement of lipid peroxidation. Free Radical Res 1998; 28:659-671.
32. Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J Anat 1999; 194:1-14.
33. Johnson EO, Zobous AB, Soucacos PN. Regeneration and repair of peripheral nerves. Injury, Int J Care Injured 2005; 36S:S24-S29.
34. Lanza C, Raimondo S, Verganil L, Catena L, Senes F, Tos P, et al. Expression of antioxidant molecules after peripheral nerve injury and regeneration. J Neurosci Res 2012; 90:842-848.
35. Zencirci SG, Bilgin MD, Yaraneri H. Electriphysiological and theoretical analysis of melatonin in peripheral nerve crush injury. J Neurosci Methods 2010; 191:277-282.
36. Welin D, Novikova LN, Wiberg M, Kellerth JO, Novikov LN. Effects of N-acetylcysteine on the survival and regeneration of sural sensory neurons in adult rats. Brain Res 2009; 1287:58-66.
37. Iida H, Nagasaka T, Shindo K, Shiozawa Z. Effect of free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. Muscle Nerve 2009; 40:582-588.
38. Ding F, Cheng Q, Gu X. The repair effects of Achyranthes bidentata extract on the crushed common peroneal nerve of rabbits. Fitoterapia 2008; 79:161-167.
39. Lin H, Wang H, Chen D, Gu Y. A dose-effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model. Microsurgery 2007; 27:673-677.
40. Ma J, Li W, Tian R, Lei W. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci Lett 2010; 478:66-71.
41. Noorafahan A, Omidi A, karbalay-Doust S. Curcumin protects the dorsal root ganglion and sciatic nerve after crush in rats. Pathol Res Pract 2011; 207:577-582.
42. Saleem S, Ahmad M, Ahmad AS, Yousuf S, Ansari MA, Khan MB, et al. Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food 2006; 9:246-253.