Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction

SpringerPlus

Volumn 3, Issue 1, 2014, Pages

  Bongers, Bart C ^a,b   Werkman, Maarten S ^b,c   Takken, Tim ^b   Hulzebos, Erik H J ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Children's Clinic De Kinderkliniek   (Netherlands)

Author keywords

Breathing pattern; Children; Pulmonary physiology; Ventilation

Indexed keywords

EID: 84916631372     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/2193-1801-3-696     Document Type: Article

References (47)

1. Almajed A, Lands LC: The evolution of exercise capacity and its limiting factors in cystic fibrosis.Paediatr Respir Rev 2012, 13:195–199. 10.1016/j.prrv.2012.01.001
2. American Thoracic Society, American College of Chest Physicians: ATS/ACCP statement on cardiopulmonary exercise testing.Am J Respir Crit Care Med 2003, 167:211–277.
3. Armstrong N, Welsman JR: Aerobic fitness. In Paediatric Exercise Science and Medicine. Edited by: Armstrong N, van Mechelen W. Oxford: Oxford University Press; 2008:101.
4. Barker AR, Williams CA, Jones AM, Armstrong N: Establishing maximal oxygen uptake in young people during a ramp cycle test to exhaustion.Br J Sports Med 2011, 45:498–503. 10.1136/bjsm.2009.063180
5. Beaver WL, Wasserman K, Whipp BJ: A new method for detecting the anaerobic threshold by gas exchange.J Appl Physiol 1986, 60:2020–2027.
6. Bongers BC, Hulzebos HJ, Arets HGM, Takken T: Validity of the oxygen uptake efficiency slope in children with cystic fibrosis and mild-to-moderate airflow obstruction.Pediatr Exerc Sci 2012, 24:129–141.
7. Borel B, Leclair E, Thevenet D, Beghin L, Gottrand F, Fabre C: Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children.Pediatr Pulmonol 2014, 49:221–229. 10.1002/ppul.22804
8. Cerny FJ, Pullano TP, Cropp GJ: Cardiorespiratory adaptations to exercise in cystic fibrosis.Am Rev Respir Dis 1982, 126:217–220.
9. Coates AL, Canny G, Zinman R, Grisdale R, Desmond K, Roumeliotis D, Levison H: The effects of chronic airflow limitation, increased dead space, and the pattern of ventilation on gas exchange during maximal exercise in advanced cystic fibrosis.Am Rev Respir Dis 1988, 138:1524–1531. 10.1164/ajrccm/138.6.1524
10. de Meer K, Jeneson JA, Gulmans VA, van der Laag J, Berger R: Efficiency of oxidative work performance of skeletal-muscle in patients with cystic-fibrosis.Thorax 1995, 50:980–983. 10.1136/thx.50.9.980
11. Dodd JD, Barry SC, Gallagher CG: Respiratory factors do not limit maximal symptom-limited exercise in patients with mild cystic fibrosis lung disease.Respir Physiol Neurobiol 2006, 152:176–185. 10.1016/j.resp.2005.08.003
12. Eid N, Yandell B, Howell L, Eddy M, Sheikh S: Can peak expiratory flow predict airflow obstruction in children with asthma?Pediatrics 2000, 105:354–358. 10.1542/peds.105.2.354
13. Fredriks AM, van Buuren S, Wit JM, Verloove-Vanhorick SP: Body index measurements in 1996–7 compared with 1980.Arch Dis Child 2000, 82:107–112. 10.1136/adc.82.2.107
14. Godfrey S: Exercise testing in children: applications in health and disease. W.B. Saunders Company Ltd, London; 1974.
15. Green DM, McDougal KE, Blackman SM, Sosnay PR, Henderson LB, Naughton KM, Collaco JM, Cutting GR: Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients.Respir Res 2010, 11:140. 10.1186/1465-9921-11-140
16. Hart N, Polkey MI, Clément A, Boulé M, Moxham J, Lofaso F, Fauroux B: Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis.Am J Respir Crit Care Med 2002, 166:61–66. 10.1164/rccm.2112059
17. Haycock GB, Schwartz GJ, Wisotsky DH: Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults.J Pediatr 1978, 93:62–66. 10.1016/S0022-3476(78)80601-5
18. Hebestreit H, Hebestreit A, Trusen A, Hughson RL: Oxygen uptake kinetics are slowed in cystic fibrosis.Med Sci Sports Exerc 2005, 37:10–17. 10.1249/01.MSS.0000150065.97657.7B
19. Heinicke K, Taivassalo T, Wyrick P, Wood H, Babb TG, Haller RG: Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms.Am J Physiol Regul Integr Comp Physiol 2011, 301:R873–884. 10.1152/ajpregu.00001.2011
20. Hjeltnes N, Stanghelle JK, Skyberg D: Pulmonary function and oxygen uptake during exercise in 16 year old boys with cystic fibrosis.Acta Paediatr Scand 1984, 73:548–553. 10.1111/j.1651-2227.1984.tb09969.x
21. Keochkerian D, Chlif M, Delanaud S, Gauthier R, Maingourd Y, Ahmaidi S: Timing and driving components of the breathing strategy in children with cystic fibrosis during exercise.Pediatr Pulmonol 2005, 40:449–56. 10.1002/ppul.20266
22. Keochkerian D, Chlif M, Delanaud S, Gauthier R, Maingourd Y, Ahmaidi S: Breathing pattern adopted by children with cystic fibrosis with mild to moderate pulmonary impairment during exercise.Respiration 2008, 75:170–177. 10.1159/000097772
23. Kusenbach G, Wieching R, Barker M, Hoffmann U, Essfeld D: Effects of hyperoxia on oxygen uptake kinetics in cystic fibrosis patients as determined by pseudo-random binary sequence exercise.Eur J Appl Physiol Occup Physiol 1999, 79:192–196. 10.1007/s004210050494
24. Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM: Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients.J Cyst Fibros 2003, 2:29–34. 10.1016/S1569-1993(02)00141-8
25. Massin MM, Leclercq-Foucart J, Sacre JP: Gas exchange and heart rate kinetics during binary sequence exercise in cystic fibrosis.Med Sci Monit 2000, 6:55–62.
26. Moorcroft AJ, Dodd ME, Morris J, Webb AK: Symptoms, lactate and exercise limitation at peak cycle ergometry in adults with cystic fibrosis.Eur Respir J 2005, 25:1050–1056. 10.1183/09031936.05.00011404
27. Moser C, Tirakitsoontorn P, Nussbaum E, Newcomb R, Cooper DM: Muscle size and cardiorespiratory response to exercise in cystic fibrosis.Am J Respir Crit Care Med 2000, 162:1823–1827. 10.1164/ajrccm.162.5.2003057
28. Nguyen T, Obeid J, Baker JM, Takken T, Pedder L, Parise G, Timmons BW: Reduced fat oxidation rates during submaximal exercise in boys with cystic fibrosis.J Cyst Fibros 2014, 13:92–98. 10.1016/j.jcf.2013.05.014
29. Ohuchi H, Nakajima T, Kawade M, Matsuda M, Kamiya T: Measurement and validity of the ventilatory threshold in patients with congenital heart disease.Pediatr Cardiol 1996, 17:7–14. 10.1007/BF02505805
30. Pastré J, Prévotat A, Tardif C, Langlois C, Duhamel A, Wallaert B: Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease.BMC Pulm Med 2014, 14:74. 10.1186/1471-2466-14-74
31. Pouliou E, Nanas S, Papamichalopoulos A, Kyprianou T, Perpati G, Mavrou I, Roussos C: Prolonged oxygen kinetics during early recovery from maximal exercise in adult patients with cystic fibrosis.Chest 2001, 119:1073–1078. 10.1378/chest.119.4.1073
32. Rand S, Prasad SA: Exercise as part of a cystic fibrosis therapeutic routine.Expert Rev Respir Med 2012, 6:341–351. 10.1586/ers.12.19
33. Regnis JA, Donnelly PM, Robinson M, Alison JA, Bye PT: Ventilatory mechanics at rest and during exercise in patients with cystic fibrosis.Am J Respir Crit Care Med 1996, 154:1418–1425. 10.1164/ajrccm.154.5.8912758
34. Saynor ZL, Barker AR, Oades PJ, Williams CA: A protocol to determine valid VO2max in young cystic fibrosis patients.J Sci Med Sport 2013, 16:539–544. 10.1016/j.jsams.2013.01.010
35. Saynor ZL, Barker AR, Oades PJ, Williams CA: Impaired aerobic function in young cystic fibrosis patients during ramp exercise.Med Sci Sports Exerc 2014, ᅟ:ᅟ. Epub ahead of print
36. Selvadurai HC, McKay KO, Blimkie CJ, Cooper PJ, Mellis CM, Van Asperen PP: The relationship between genotype and exercise tolerance in children with cystic fibrosis.Am J Respir Crit Care Med 2002, 165:762–765. 10.1164/ajrccm.165.6.2104036
37. Selvadurai HC, Allen J, Sachinwalla T, Macauley J, Blimkie CJ, Van Asperen PP: Muscle function and resting energy expenditure in female athletes with cystic fibrosis.Am J Respir Crit Care Med 2003, 168:1476–1480. 10.1164/rccm.200303-363OC
38. Shah AR, Gozal D, Keens TG: Determinants of aerobic and anaerobic exercise performance in cystic fibrosis.Am J Respir Crit Care Med 1998, 157:1145–1150. 10.1164/ajrccm.157.4.9705023
39. Sovtic AD, Minic PB, Kosutic J, Markovic-Sovtic GP, Gajic MB: Static hyperinflation is associated with decreased peak exercise performance in children with cystic fibrosis.Respir Care 2013, 58:291–297. 10.4187/respcare.01946
40. Stevens D, Oades PJ, Armstrong N, Williams CA: Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.Pediatr Pulmonol 2009, 44:480–488. 10.1002/ppul.21024
41. Thin AG, Dodd JD, Gallagher CG, Fitzgerald MX, Mcloughlin P: Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis.Respir Med 2004, 98:1063–1070. 10.1016/j.rmed.2004.03.016
42. Wasserman K, Zhang YY, Riley MS: Ventilation during exercise in chronic heart failure.Basic Res Cardiol 1996,91(Suppl. 1):1–11.
43. Wasserman K, Hansen JE, Sue DY, Stringer WW, Whipp BJ: Principles of exercise testing and interpretation: including pathophysiology and clinical applications. Lippincott Williams & Wilkins, Philadelphia; 2005.
44. Werkman MS, Hulzebos HJ, Arets HG, van der Net J, Helders PJ, Takken T: Is static hyperinflation a limiting factor during exercise in adolescents with cystic fibrosis?Pediatr Pulmonol 2010, 46:119–124.
45. Wideman L, Baker CF, Brown PK, Consitt LA, Ambrosius WT, Schechter MS: Substrate utilization during and after exercise in mild cystic fibrosis.Med Sci Sports Exerc 2009, 41:270–278.
46. Wilkens H, Weingard B, Lo Mauro A, Schena E, Pedotti A, Sybrecht GW, Aliverti A: Breathing pattern and chest wall volumes during exercise in patients with cystic fibrosis, pulmonary fibrosis and COPD before and after lung transplantation.Thorax 2010, 65:808–814. 10.1136/thx.2009.131409
47. Zapletal A, Samenek M, Paul T: Lung function in children and adolescents: methods, reference values. In Progress in respiration research. Edited by: Herzog H. Basel: Karger; 1987:114–218.