Reduced fat oxidation rates during submaximal exercise in boys with cystic fibrosis

Journal of Cystic Fibrosis

Volumn 13, Issue 1, 2014, Pages 92-98

  Nguyen, Thanh ^a   Obeid, Joyce ^a   Baker, Jeff M ^a,b   Takken, Tim ^a,c   Pedder, Linda ^d   Parise, Gianni ^a,b   Timmons, Brian W ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d MCMASTER CHILDREN S HOSPITAL   (Canada)

Author keywords

Cycling; Cystic fibrosis; Free fatty acids; Substrate utilization

Indexed keywords

CARBOHYDRATE; FATTY ACID; GLUCOSE; INSULIN;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENERGY EXPENDITURE; EXERCISE; FAT FREE MASS; FATTY ACID BLOOD LEVEL; GAS; GAS EXCHANGE; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; LUNG FUNCTION; MALE; OXIDATION; SCHOOL CHILD;

CYCLING; CYSTIC FIBROSIS; FREE FATTY ACIDS; SUBSTRATE UTILIZATION;

ADOLESCENT; BICYCLING; BLOOD GLUCOSE; CHILD; CYSTIC FIBROSIS; DIETARY CARBOHYDRATES; DIETARY FATS; ENERGY METABOLISM; EXERCISE; FATTY ACIDS, NONESTERIFIED; HUMANS; INSULIN; LIFE; LIPID METABOLISM; MALE; MODELS, BIOLOGICAL; NUTRITIONAL STATUS; OXIDATION-REDUCTION; OXYGEN CONSUMPTION;

EID: 84890429688     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2013.05.014     Document Type: Article

References (29)

1. Wouthuyzen-Bakker M., Bodewes F.A., Verkade H.J. Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice. J Cyst Fibros 2011, 10:150-158.
2. Coste T.C., Armand M., Lebacq J., Lebecque P., Wallemacq P., Leal T. An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis. Clin Biochem 2007, 40:511-520.
3. Borowitz D., Baker R.D., Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 2002, 35:246-259.
4. Matel J.L., Milla C.E. Nutrition in cystic fibrosis. Semin Respir Crit Care Med 2009, 30:579-586.
5. Cystic Fibrosis Canada Canadian Patient Data Registry Report 2009 Retrieved from, [cited 2011 Jan 25]. http://www.cysticfibrosis.ca.
6. Wilkes D.L., Schneiderman J.E., Nguyen T., Heale L., Moola F., Ratjen F., et al. Exercise and physical activity in children with cystic fibrosis. Paediatr Respir Rev 2009, 10:105-109.
7. Nixon P.A., Orenstein D.M., Kelsey S.F., Doershuk C.F. The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med 1992, 327:1785-1788.
8. Pianosi P., Leblanc J., Almudevar A. Peak oxygen uptake and mortality in children with cystic fibrosis. Thorax 2005, 60:50-54.
9. Schneiderman-Walker J., Wilkes D.L., Strug L., Lands L.C., Pollock S.L., Selvadurai H.C., et al. Sex differences in habitual physical activity and lung function decline in children with cystic fibrosis. J Pediatr 2005, 147:321-326.
10. Orenstein D.M., Franklin B.A., Doershuk C.F., Hellerstein H.K., Germann K.J., Horowitz J.G., et al. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program. Chest 1981, 80:392-398.
11. Gruber W., Orenstein D.M., Braumann K.M., Huls G. Health-related fitness and trainability in children with cystic fibrosis. Pediatr Pulmonol 2008, 43:953-964.
12. Selvadurai H.C., Blimkie C.J., Meyers N., Mellis C.M., Cooper P.J., Van Asperen P.P. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol 2002, 33:194-200.
13. Wideman L., Baker C.F., Brown P.K., Consitt L.A., Ambrosius W.T., Schechter M.S. Substrate utilization during and after exercise in mild cystic fibrosis. Med Sci Sports Exerc 2009, 41:270-278.
14. Spicher V., Roulet M., Schutz Y. Assessment of total energy expenditure in free-living patients with cystic fibrosis. J Pediatr 1991, 118:865-872.
15. Bongers B.C., Hulzebos E.H., Arets B.G., Takken T. Validity of the oxygen uptake efficiency slope in children with cystic fibrosis and mild-to-moderate airflow obstruction. Pediatr Exerc Sci 2012, 24:129-141.
16. Mirwald R.L., Baxter-Jones A.D., Bailey D.A., Beunen G.P. An assessment of maturity from anthropometric measurements. Med Sci Sports Exerc 2002, 34:689-694.
17. Schaefer F., Georgi M., Zieger A., Scharer K. Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res 1994, 35:617-624.
18. Nguyen T., Obeid J., Ploeger H.E., Takken T., Pedder L., Timmons B.W. Inflammatory and growth factor response to continuous and intermittent exercise in youth with cystic fibrosis. J Cyst Fibros 2012, 11:108-118.
19. Peronnet F., Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci 1991, 16:23-29.
20. Dill D.B., Costill D.L. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 1974, 37:247-248.
21. Zunquin G., Theunynck D., Sesboue B., Arhan P., Bougle D. Comparison of fat oxidation during exercise in lean and obese pubertal boys: clinical implications. Br J Sports Med 2009, 43:869-870.
22. Al-Jaouni R., Schneider S.M., Piche T., Rampal P., Hebuterne X. Effect of steroids on energy expenditure and substrate oxidation in women with Crohn's disease. Am J Gastroenterol 2002, 97:2843-2849.
23. Bennard P., Imbeault P., Doucet E. Maximizing acute fat utilization: effects of exercise, food, and individual characteristics. Can J Appl Physiol 2005, 30:475-499.
24. Havel R.J., Naimark A., Borchgrevink C.F. Turnover rate and oxidation of free fatty acids of blood plasma in man during exercise: studies during continuous infusion of palmitate-1-C14. J Clin Invest 1963, 42:1054-1063.
25. Lafontan M., Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 2009, 48:275-297.
26. Ranallo R.F., Rhodes E.C. Lipid metabolism during exercise. Sports Med 1998, 26:29-42.
27. Ali B.R. Is cystic fibrosis-related diabetes an apoptotic consequence of ER stress in pancreatic cells?. Med Hypotheses 2009, 72:55-57.
28. Centers for Disease Control and Prevention Percentile data files with LMS values Retrieved from, [cited 2011 Dec 29]. http://www.cdc.gov/growthcharts/percentile_data_files.htm.
29. Wang X., Dockery D.W., Wypij D., Fay M.E., Ferris B.G. Pulmonary function between 6 and 18years of age. Pediatr Pulmonol 1993, 15:75-88.