Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulation

Molecular Medicine Reports

Volumn 11, Issue 3, 2015, Pages 1820-1826

  Zhang, Ling ^a   Yang, Bo ^a   Zhou, Ke ^a   Li, Hua ^a   Li, Dong ^a   Gao, Hui ^a   Zhang, Tao ^a   Wei, Dong ^a   Li, Zhihui ^a   Diao, Yong ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Breast cancer; Cell cycle; Differentially expressed genes; Genistein

Indexed keywords

ALCOHOL; DNA; GENISTEIN; ANTINEOPLASTIC AGENT; PHYTOESTROGEN; PROTEIN KINASE INHIBITOR;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DNA REPLICATION; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; MCF 7 CELL LINE; SUPPORT VECTOR MACHINE; BIOLOGY; BREAST NEOPLASMS; CELL CYCLE; CLUSTER ANALYSIS; DRUG EFFECTS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GENISTEIN; HUMANS; PHYTOESTROGENS; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 84916623081     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2907     Document Type: Article

References (42)

1. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
2. Brenner H: Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis. Lancet 360: 1131-1135, 2002.
3. Goldhirsch A, Glick JH, Gelber RD, Coates AS and Senn HJ: Meeting highlights: International consensus panel on the treatment of primary breast cancer. Seventh international conference on adjuvant therapy of primary breast cancer. J Clin Oncol 19: 3817-3827, 2001.
4. Nathanson KL, Wooster R and Weber BL: Breast cancer genetics: what we know and what we need. Nat Med 7: 552-556, 2001.
5. Rahman N and Stratton MR: The genetics of breast cancer susceptibility. Annu Rev Genet 32: 95-121, 1998.
6. King MC, Marks JH and Mandell JB; New York Breast Cancer Study Group: Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302: 643-646, 2003.
7. Dixon RA and Ferreira D: Genistein. Phytochemistry 60: 205-211, 2002.
8. Marini H, Minutoli L, Polito F, et al: Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 146: 839-847, 2007.
9. Fritz WA, Coward L, Wang J and Lamartiniere CA: Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19: 2151-2158, 1998.
10. Lamartiniere CA: Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 71 (Suppl): 1705S-1709S, 2000.
11. Hsieh CY, Santell RC, Haslam SZ and Helferich WG: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58: 3833-3838, 1998.
12. Messina MJ and Loprinzi CL: Soy for breast cancer survivors: a critical review of the literature. J Nutr 131 (Suppl): 3095S-3108S, 2001.
13. Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR and Helferich WG: Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 131: 2957-2962, 2001.
14. Shioda T, Chesnes J, Coser KR, et al: Importance of dosage standardization for interpreting transcriptomal signature profiles: evidence from studies of xenoestrogens. Proc Natl Acad Sci USA 103: 12033-12038, 2006.
15. Fujita A, Sato J, Rodrigues Lde O, Ferreira CE and Sogayar MC: Evaluating different methods of microarray data normalization. BMC Bioinformatics 7: 469, 2006.
16. Troyanskaya O, Cantor M, Sherlock G, et al: Missing value estimation methods for DNA microarrays. Bioinformatics 17: 520-525, 2001.
17. Smyth GK: Limma: linear models for microarray data. In: Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey V, Dudoit S, Irizarry R and Huber W (eds). Springer, New York, NY, pp397-420, 2005.
18. Tatusov RL, Natale DA, Garkavtsev IV, et al: The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res 29: 22-28, 2001.
19. Altschul SF, Gish W, Miller W, Myers EW and Lipman DJ: Basic local alignment search tool. J Mol Biol 215: 403-410, 1990.
20. Giot L, Bader JS, Brouwer C, et al: A protein interaction map of Drosophila melanogaster. Science 302: 1727-1736, 2003.
21. Deng M, Zhao JY, Ju XD, Tu PF, Jiang Y and Li ZB: Protective effect of tubuloside B on TNFalpha-induced apoptosis in neuronal cells. Acta Pharmacol Sin 25: 1276-1284, 2004.
22. Breitkreutz B-J, Stark C and Tyers M: Osprey: a network visualization system. Genome Biol 4: R22, 2003.
23. Willis RC and Hogue CW: Searching, viewing, and visualizing data in the Biomolecular Interaction Network Database (BIND). Curr Protoc Bioinformatics: Chapter 8: Unit 8.9, 2006.
24. Breitkreutz BJ, Stark C and Tyers M: The GRID: the General Repository for Interaction Datasets. Genome Biol 4: R23, 2003.
25. Nam D and Kim SY: Gene-set approach for expression pattern analysis. Brief Bioinform 9: 189-197, 2008.
26. Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57, 2009.
27. Zhang B, Kirov S and Snoddy J: WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33: W741-W748, 2005.
28. Duncan D, Prodduturi N and Zhang B: WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit. BMC Bioinformatics 11: P10, 2010.
29. Coles C, Condie A, Chetty U, Steel CM, Evans HJ and Prosser J: p53 mutations in breast cancer. Cancer Res 52: 5291-5298, 1992.
30. Giancotti V: Breast cancer markers. Cancer Lett 243: 145-159, 2006.
31. Ganz PA: Breast cancer, menopause, and long-term survivorship: critical issues for the 21st century. Am J Med 118: 136-141, 2005.
32. Yu H: Cdc20: A WD40 activator for a cell cycle degradation machine. Mol Cell 27: 3-16, 2007.
33. Yuan B, Xu Y, Woo JH, et al: Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability. Clin Cancer Res 12: 405-410, 2006.
34. Agarwal R, Gonzalez-Angulo AM, Myhre S, et al: Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res 15: 3654-3662, 2009.
35. Gonzalez MA, Pinder SE, Callagy G, et al: Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol 21: 4306-4313, 2003.
36. Yang J, Ramnath N, Moysich KB, et al: Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer 6: 203, 2006.
37. Sotiriou C, Neo SY, McShane LM, et al: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci USA 100: 10393-10398, 2003.
38. Cappelletti V, Fioravanti L, Miodini P and Di Fronzo G: Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle. J Cell Biochem 79: 594-600, 2000.
39. Fioravanti L, Cappelletti V, Miodini P, Ronchi E, Brivio M and Di Fronzo G: Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett 130: 143-152, 1998.
40. Li Y, Upadhyay S, Bhuiyan M and Sarkar FH: Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 18: 3166-3172, 1999.
41. Salomons GS, Brady HJ, Verwijs-Janssen M, et al: The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. Int J Cancer 71: 959-965, 1997.
42. Ren C, Li L, Yang G, et al: RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res 64: 969-976, 2004.