Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke

Journal of Neuroscience

Volumn 34, Issue 50, 2014, Pages 16784-16795

  Mracsko, Eva ^a   Liesz, Arthur ^a,b,c   Stojanovic, Ana ^d   Lou, Wilson Pak Kin ^e   Osswald, Matthias ^f,g   Zhou, Wei ^a   Karcher, Simone ^a   Winkler, Frank ^f,g   Martin Villalba, Ana ^e   Cerwenka, Adelheid ^d   Veltkamp, Roland ^a,h  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Technische Universität München Munich Cluster for Systems Neurology   (Germany)

^d Department of Immunology and Cell Biology   (Germany)

^e Molecular Neurobiology   (Germany)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^h IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cytotoxic T lymphocytes; Ischemic stroke; NK cells; Perforin

Indexed keywords

CD69 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; IMMUNOGLOBULIN G; MICROTUBULE ASSOCIATED PROTEIN 2; PERFORIN; RAG1 PROTEIN; CYTOTOXIN; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CRANIECTOMY; CYLINDER TEST; EXPERIMENTAL STROKE; EXPERIMENTAL TEST; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NATURAL KILLER CELL; NEUROPROTECTION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SENSORIMOTOR FUNCTION; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CEREBROVASCULAR ACCIDENT; CHEMICALLY INDUCED; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; TOXICITY;

ANIMALS; ANTIGENS, CD; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXINS; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERFORIN; STROKE;

EID: 84916619915     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1867-14.2014     Document Type: Article

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