Clematichinenoside inhibits VCAM-1 and ICAM-1 expression in TNF-α-treated endothelial cells via NADPH oxidase-dependent IκB kinase/NF-κB pathway

Free Radical Biology and Medicine

Volumn 78, Issue , 2015, Pages 190-201

  Yan, Simin ^a   Zhang, Xu ^a   Zheng, Haili ^a   Hu, Danhong ^a   Zhang, Yongtian ^a   Guan, Qinghua ^a   Liu, Lifang ^a   Ding, Qilong ^a   Li, Yunman ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adhesion; Clematichinenoside; NADPH oxidase; NF B; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; CATALASE; CLEMATICHINENOSIDE; I KAPPA B KINASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MACROGOL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SAPONIN DERIVATIVE; SYNAPTOTAGMIN I; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SAPONIN;

ARTICLE; CELL ADHESION; CELL FREE SYSTEM; CELL STIMULATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FREE RADICAL SCAVENGING ASSAY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MONOCYTE; MTT ASSAY; NITROBLUE TETRAZOLIUM TEST; OXIDATION REDUCTION STATE; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPRECIPITATION; LEUKOCYTE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

CLEMATIS CHINENSIS;

BLOTTING, WESTERN; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; MONOCYTES; NADPH OXIDASE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SAPONINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84916613817     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.11.004     Document Type: Article

References (41)

1. IIeana, M.; Maya, S. Inflammation in atherosclerosis: a cause or a result of vascular disorders? J. Cell. Mol. Med. 16:1978-1990; 2012.
2. Libby, P. Inflammation in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 32:2045-2051; 2012.
3. Fenyo, I. M.; Gafencu, A. V. The involvement of the monocytes/macrophages in chronic inflammation associated with atherosclerosis. Immunobioloy 218:1376-1384; 2012.
4. Moore, K. J.; Sheedy, F. J.; Fisher, E. A. Macrophages in atherosclerosis: a dynamic balance. Nat. Rev. Immuol 13:709-721; 2013.
5. Newton, K.; Dixit, V. M. Signaling in innate immunity and inflammation. Cold. Spring. Harb. Perspect. Biol. 4:a06049; 2012.
6. Hayden, M. S.; Ghosh, S. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes. Dev. 26:203-234; 2012.
7. Chiurchiu, V.; Mccarrone, M. Chronic inflammatory disorders ad their redox control: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 15:2605-2641; 2011.
8. Lubos, E.; Kelly, N. J.; Oldebeken, S. R.; Leopold, J. A.; Zhang, Y. Y.; Loscalzo, J.; Handy, D. E. Glutathione peroxidase-1 deficiency augments proinflammatory ciency augments proinflammatory cytokine-induced redox signaling and human endothelial ll activation. J. Biol. Chem. 286:35407-35417; 2011.
9. Cook-Mills, J. M.; Marchese, M. E.; Abdala-Valencia, H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid. Redox Signal. 15:1607-1638; 2011.
10. Kim, J. J.; Lee, S. B.; Park, J. K.; Yoo, Y. D. TNF-alpha-induced ROS production triggering apoptosis s directly linked to Romo 1 and Bcl-X(L). Cell. Death Differ. 17:1420-1434; 2010.
11. Nathan, C.; Cuningham-Bussel, A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat. Rev. Immunol. 13:349-361; 2013.
12. Zhang, M.; Shah, A. M. ROS signaling between endothelia cells and cardiac cells. Cardiovasc. Res. 102:249-257; 2014.
13. Joo, H. K.; Lee, Y. R.; Lim, S. Y.; Lee, E. J.; Choi, S.; Cho, E. J.; Park, M. S.; Park, J. B.; Jeon, B. H. Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1. FEBS. Lett. 586:1355-1394; 2012.
14. Herder, M.; Arntzen, K. A.; Johnsen, S. H.; Eggen, A. E.; Mathiesen, E. B. Long-term use of lipid-lowering drugs slows progression of carotid atherosclerosis: the Tromso study 1994 to 2008. Arterioscler. Thromb. Vasc. Biol. 33:858-862; 2013.
15. Lievens, D.; von. Hundelshausen, P. Platelets in atherosclerosis. Thromb. Haemost. 106:827-838; 2011.
16. Charo, I. F.; Taub, R. Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat. Rev. Drug. Discov. 10:365-376; 2011.
17. Zhang, R.; Fang, W.; Han, D.; Sha, L.; Wei, J.; Liu, L.; Li, Y. Clematichinenoside attenuates myocardial infarction in ischemia/reperfusion injury both in vivo and in vitro. Planta Med. 79:1289-1297; 2013.
18. Han, W.; Xiong, Y.; Li, Y.; Fang, W.; Ma, Y.; Liu, L.; Li, F.; Zhu, X. Anti-arthritic effects of clematichinenosid (AR-6) on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis. Pharm. Biol. 51:13-22; 2013.
19. Kim, J. H.; Yu, Y. S.; Park, K. H.; Kang, H. J.; Lee, H. Y.; Kim, K. W. Antiangiogenic effect of deguelin on choroidal neovascularization. J. Pharmacol. Exp. Ther. 324:643-647; 2008.
20. Rhee, W. J.; Ni, C. W.; Zheng, Z.; Chang, K.; Jo, H.; Bao, G. HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc. Natl. Acad. Sci. USA 107:6858-6863; 2010.
21. Balwani, S.; Nandi, D.; Jaisankar, P.; Ghosh, B. 2-Methyl-pyran-4-one -3-O-β-D-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFα-induced cell adhesion molecules expression by blocking nuclear transcription factor-κB (NF-κB). Biochimie 93:921-930; 2011.
22. Wang, L.; Wu, B.; Sun, Y.; Xu, T.; Zhang, X.; Zhou, M.; Jiang, W. Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation. Br. J. Anaesth. 104:606-612; 2010.
23. Lee, S. J; Cho, S. C; Lee, E. J; Kim, S; Lee, S. B; Lim, J. H; Choi, Y. H; Kim, W. J; Moon, S. K. Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase(ERK)-mediated MMP-9 protein expression leading to nuclear factor(NF-κB) activation by inducing the up-regulation of p21(WAF1) protein expression. J. Biol. Chem. 288:5539-5552; 2013.
24. Raghava, S; Subramaniyam, G; Shanmugam, N. Proinfl ammatory effects of malondialdehyde in lymphocytes. J. Leukoc. Biol. 92:1055-1067; 2012.
25. Wojciak-Stothard, B; Torondel, B; Zhao, L; Renné, T; Lepiper, J. M. Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function. Mol. Biol. Cell 20: 33-42; 2009.
26. Derochetts, S.; Franck, T.; Mouithys-Mickalad, A.; Ceusters, J.; Deby-Dupont, G.; Lejeune, J. P.; Veven, P.; Serteyn, D. Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils. Chem. Biol. Interact. 25:186-193; 2013.
27. Chompoo, J.; Upadhyay, A.; Fukuta, M.; Tawata, S. Effect of Alpinia zerumber components on antioxidant and skin diseases-related enzymes. BMC Complement. Altern. Med. 12:106-114; 2012.
28. Miao, Z.; Tai, H. M.; Yan, B. W.; Min, J. S. Evaluation of free radical-scavenging activities of sweet potato protein and its hydrolysates as affected by single and combination of enzyme systems. Int. J. Food. Sci. Technol. 47:696-702; 2012.
29. Sun, S. X.; Li, Y. M.; Fang, W. R.; Cheng, P.; Liu, L.; Li, F. Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin. Exp. Med. 10:113-121; 2010.
30. Fujioka, S.; Niu, J.; Schmidt, C.; Sclabas, G. M.; Peng, B.; Uwagawa, T.; Li, Z.; Evans, D. B.; Abbruzzese, J. L.; Chiao, P. J. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol. Cell. Biol. 24:7806-7819; 2004.
31. Tsoyi, K.; Jang, H. J.; Nizamutdinova, I. T.; Park, K.; Kim, Y. M.; Kim, H. J.; Seo, H. G.; Lee, J. H.; Chang, K. C. PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α- activated human endothelial cells. Atherosclerosis 213:115-121; 2010.
32. Hadad, N.; Tuval, L.; Elgazar-Crmom, V.; Levy, R. Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2α via both NF-κB and CREB transcription factors. J. Immunol. 186: 1816-1827; 2011.
33. Vallabhapurapu, S; Karin, M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733; 2009.
34. Peng, C.; Perera, P. K.; Li, Y. M.; Fang, W. R.; Liu, L. F.; Li, F. W. Antiinflammatory effects of Clematis chinensis Osbeck extract (AR-6) may be associated with NF-κB, TNF-α, and COX-2 in collagen-induced arthritis in rat. Rheumatol. Int. 32: 3119-3125; 2012.
35. Oeckinghas, A.; Hayden, M. S.; Ghosh, S. Crosstalk in NF-κB signaling pathways. Nat. Immunol. 12:695-708; 2011.
36. Morgan, M. J.; Liu, Z. G. Crosstalk of reactive oxygen species and NF-κB signaling. Cell. Res. 21:103-115; 2011.
37. Wei, S.; He, W.; Lu, J.; Wang, Z.; Yamshita, K.; Yokoyama, M.; Kodama, H. Effects of five oleanolic acid triterpenoid saponins from the rhizome of Anemone raddeana on stimulus-induced superoxide generation, phosphorylation of proteins and translocation of cytosolic compounds to cell membrane in human neutrophils. Fitoterapia 83:402-407; 2012.
38. Fransen, M.; Nordgren, M.; Wang, B.; Apanasets, O. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim. Biophys. Acta 1822:1363-1373; 2012.
39. Basuroy, S.; Tcheranova, D.; Bhattacharya, S.; Leffler, C. W.; Parfenova, H. Nox4 NADPH oxidase derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis. Am. J. Physiol. Cell. Physiol 300:C256-C265; 2011.
40. Touyz, R. M.; Briones, A. M.; Sedeek, M.; Burger, D.; Montezano, A. C. NOX isoforms and reactive oxygen species in vascular health. Mol. Interv. 11:27-35; 2011.
41. David, D. New; Karen, B.; Basant, B.; Yves, G.; Hanna, E. A. IGF-1 increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am. J. Physiol. Cell Physiol 302:C122-C130; 2012.