Clematichinenoside attenuates myocardial infarction in ischemia/reperfusion injury both in vivo and in vitro

Planta Medica

Volumn 79, Issue 14, 2013, Pages 1289-1297

  Zhang, Rui ^a   Fang, Weirong ^a   Han, Dan ^a   Sha, Lan ^a   Wei, Jie ^a   Liu, Lifang ^a   Li, Yunman ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

clematichinenoside; Clematis chinensis; myocardial ischemia reperfusion; nitric oxide; oxidative stress; Ranunculaceae; ventricular myocytes

Indexed keywords

ANTIOXIDANT; CLEMATICHINENOSIDE; CREATINE KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DOSE RESPONSE; ENZYME ACTIVITY; EX VIVO STUDY; EXPERIMENTAL GUINEA PIG; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEMODYNAMICS; IN VIVO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

CAVIA; CLEMATIS CHINENSIS; RANUNCULACEAE; RATTUS;

ANIMALS; ANTIOXIDANTS; CLEMATIS; CREATINE KINASE; DRUGS, CHINESE HERBAL; GUINEA PIGS; HEART VENTRICLES; HEMODYNAMICS; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SUPEROXIDE DISMUTASE;

EID: 84885019816     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0033-1350671     Document Type: Article

References (25)

1. Guilbert J. J. The world health report 2002 - reducing risks, promoting healthy life. Educ Health (Abingdon): 2003; 16 230
2. Kloner R. A. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis: 2006; 48 285 300 (Pubitemid 43326303)
3. Commission CP Pharmacopoeia of the Peoples Republic of China. Beijing Chemical Industry Press: 2005; 175
4. Sun S. X., Li Y. M., Fang W. R., Cheng P., Liu L., Li F. Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin Exp Med: 2010; 10 113 121
5. Han W., Xiong Y., Li Y., Fang W., Ma Y., Liu L., Li F., Zhu X. Anti-arthritic effects of clematichinenoside (AR-6) on PI3K/Akt signaling pathway and TNF- α associated with collagen-induced arthritis. Pharm Biol: 2013; 51 13 22
6. Peng C., Perera P. K., Li Y. M., Fang W. R., Liu L. F., Li F. W. Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF- κ B, TNF-α, and COX-2 in collagen-induced arthritis in rat. Rheumatol Int: 2012; 32 3119 3125
7. Liu L. F., Ma X. L., Wang Y. X., Li F. W., Li Y. M., Wan Z. Q., Tang Q. L. Triterpenoid saponins from the roots of Clematis chinensis Osbeck. J Asian Nat Prod Res: 2009; 11 389 396
8. Ueda S., Yamagishi S., Matsui T., Jinnouchi Y., Imaizumi T. Administration of pigment epithelium-derived factor inhibits left ventricular remodeling and improves cardiac function in rats with acute myocardial infarction. Am J Pathol: 2011; 178 591 598
9. Long J., Gao M., Kong Y., Shen X., Du X., Son Y. O., Shi X., Liu J., Mo X. Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine: 2012; 19 672 676
10. Ibarra-Alvarado C., Rojas A., Mendoza S., Bah M., Gutierrez D. M., Hernandez-Sandoval L., Martinez M. Vasoactive and antioxidant activities of plants used in Mexican traditional medicine for the treatment of cardiovascular diseases. Pharm Biol: 2010; 48 732 739
11. Misra M. K., Sarwat M., Bhakuni P., Tuteja R., Tuteja N. Oxidative stress and ischemic myocardial syndromes. Med Sci Monit: 2009; 15 RA209 RA219
12. Sadek H. A., Humphries K. M., Szweda P. A., Szweda L. I. Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Arch Biochem Biophys: 2002; 406 222 228 (Pubitemid 35216348)
13. ATP channels. Pharmacol Res: 2010; 61 342 348
14. Fu J., Huang H., Liu J., Pi R., Chen J., Liu P. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol: 2007; 568 213 221 (Pubitemid 46976900)
15. Maehata Y., Miyagawa S., Sawa Y. Activated protein C has a protective effect against myocardial I/R injury by improvement of endothelial function and activation of AKT1. PLoS One: 2012; 7 e38738
16. Zhang Y., Wei L., Sun D., Cao F., Gao H., Zhao L., Du J., Li Y., Wang H. Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats. Diabetes Obes Metab: 2010; 12 316 322
17. Wattanapitayakul S. K., Bauer J. A. Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Pharmacol Ther: 2001; 89 187 206 (Pubitemid 32333040)
18. Forstermann U., Closs E. I., Pollock J. S., Nakane M., Schwarz P., Gath I., Kleinert H. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension: 1994; 23 1121 1131 (Pubitemid 24180877)
19. Otani H. The role of nitric oxide in myocardial repair and remodeling. Antioxid Redox Signal: 2009; 11 1913 1928
20. Houshmand F., Faghihi M., Zahediasl S. Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats. Peptides: 2009; 30 2301 2308
21. Peng J., Xiao J., Ye F., Deng H. W., Li Y. J. Inhibition of cardiac tumor necrosis factor-α production by calcitonin gene-related peptide-mediated ischemic preconditioning in isolated rat hearts. Eur J Pharmacol: 2000; 407 303 308
22. Germack R., Griffin M., Dickenson J. M. Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes. J Mol Cell Cardiol: 2004; 37 989 999 (Pubitemid 39446824)
23. Fang W., Deng Y., Li Y., Shang E., Fang F., Lv P., Bai L., Qi Y., Yan F., Mao L. Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury. Eur J Pharm Sci: 2010; 39 8 14
24. Takano H., Manchikalapudi S., Tang X. L., Qiu Y., Rizvi A., Jadoon A. K., Zhang Q., Bolli R. Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. Circulation: 1998; 98 441 449 (Pubitemid 28357947)
25. Deng Y., Fang W., Li Y., Cen J., Fang F., Lv P., Gong S., Mao L. Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. Eur J Pharmacol: 2009; 616 43 47