Large elastic artery stiffness with aging: Novel translational mechanisms and interventions

Aging and Disease

Volumn 4, Issue 2, 2013, Pages 76-83

  Fleenor, Bradley S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Advanced glycation endproducts; Adventitia; Collagen; Elastin; Inflammation; Intima; Media; Oxidative stress

Indexed keywords

EID: 84916603806     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review

References (64)

1. Lakatta EG, Levy D (2003). Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A "Set Up" for Vascular Disease. Circulation, 107:139-46.
2. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Moxaffarian D, Mussolino ME, Nichol G, Paynter NP, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2012). Heart Disease and Stroke Statistics -- 2012 Update: A Report From the American Heart Association. Circulation, 125:e2-e220.
3. Mattace-Raso FUS, van der Cammen TJM, Hofman A, van Popele NM, Bos ML, Schalekamp MADH, Asmar R, Reneman RS, Hoeks APG, Breteler MMB, Witteman JCM (2006). Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study. Circulation, 113:657-63.
4. Mitchell GF, Hwang S-J, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ (2010). Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study. Circulation, 121:505-11.
5. Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, Simonsick EM, Havlik R, Lakatta EG, Spurgeon H, Kritchevsky S, Pahor M, Bauer D, Newman A (2005). Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults. Circulation, 111:3384-90.
6. Willum Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs, L, Ibsen H, Jeppesen J (2006). Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population. Circulation, 113:664-70.
7. Diez J. Arterial stiffness and extracellular matrix (2007). Adv Cardiol, 44:76-95.
8. Zieman SJ, Melenovsky V, Kass DA (2005). Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness. Arterioscler Thromb Vasc Biol, 25:932-43.
9. Zieman SJ, Vojtech M, Clattenburg L, Corretti MC, Capriotti AR, Gerstenblith G, Kass DA (2007). Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J Hypertens, 25:577-83.
10. Steppan J, Tran H, Benjo AM, Pellakuru L, Barodka V, Ryoo S, Nyhan SM, Lussman C, Gupta G, White AR, Daher JP, Shoukas AA, Levine BD, Berkowitz (2012). Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Exp Gerontol, 47:565-72.
11. Fleenor BS, Seals DR, Zigler ML, Sindler AL (2012). Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging Cell, 11:269-276.
12. Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR (2012). Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products. Exp Gerontol, 47:588-94.
13. Francia P, Delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Luscher, TF, Volpe M, Cosentino F (2004). Deletion of p66shc Gene Protects Against Age-Related Endothelial Dysfunction. Circulation, 110:2889-95.
14. Hamilton CA, Brosnan MJ, McIntyre M, Graham D, Dominiczak AF (2001). Superoxide Excess in Hypertension and Aging: A Common Cause of Endothelial Dysfunction. Hypertension, 37:529-34.
15. Lesniewski LA, Durrant JR, Connell ML, Henson GD, Black AD, Donato AJ, Seals DR (2011). Aerobic exercise reverses arterial inflammation with aging in mice. Am J Physiol Heart Circ Physiol, 301:H1025-H32.
16. Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM (2009). Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol, 587:3885-97.
17. Sindler AL, Fleenor BS, Calvert JW, Marshall KD, Zigler ML, Lefer DJ, Seals DR (2011). Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell, 10:429-37.
18. Zou Y, Yoon S, Jung KJ, Kim CH, Son TG, Kim MS, Kim YJ, Lee J, Yu BP, Chung HY (2006). Upregulation of aortic adhesion molecules during aging. J Gerontol A Biol Sci Med Sci, 61:232-44.
19. Csiszar A, Wang M, Lakatta EG, Ungvari Z (2008). Inflammation and endothelial dysfunction during aging: role of NF-κB. J Appl Physiol, 105:1333-41.
20. Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A (2010). Mechanisms of Vascular Aging: New Perspectives. J Gerontol A Biol Sci Med Sci, 65:1028-41.
21. Marik PE, Varon J (2009). Omega-3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic Review. Clin Cardiol, 32:365-72.
22. Miura H, Nakagawa E, Takahashi Y (2008). Influence of group training frequency on arterial stiffness in elderly women. Eur J Appl Physiol, 104:1039-44.
23. Okada S, Hiuge A, Makino H, Nagumo A, Takaki H, Konishi H, Goto Y, Yoshimasa Y, Miyamoto Y (2010). Effect of Exercise Intervention on Endothelial Function and Incidence of Cardiovascular Disease in Patients with Type 2 Diabetes. J Atheroscler Thromb, 17:828-33.
24. Patel S, Shi Y, Niculescu R, Chung EH, Martin JL, Zalewski A (2000). Characteristics of Coronary Smooth Muscle Cells and Adventitial Fibroblasts. Circulation, 101:524-32.
25. Ruckman JL, Luvalle PA, Hill KE, Giro MG, Davidson JM (1994). Phenotypic stability and variation in cells of the porcine aorta: collagen and elastin production. Matrix Biol, 14:135-45.
26. Sauvage M, Hinglais N, Mandet C, Badier C, Deslandes F, Michel JB Jacob MP (1998). Localization of elastin mRNA and TGF-ß1 in rat aorta and caudal artery as a function of age. Cell Tissue Res, 291:305-14.
27. Fleenor BS, Marshall KD, Rippe C, Seals DR (2012). Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: Potential role of inflammation. J Vasc Res, 49:59-64.
28. Basta G, Lazzerini G, Massaro M, Simoncini T, Tanganelli P, Fu C, Kislinger T, Stern DM, Schmidt AM, De Caterina R (2002). Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation, 105:816-22.
29. Fleenor BS, Marshall KD, Durrant JR, Lesniewski LA, Seals DR (2010). Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol, 588:3971-82.
30. Wang M, Zhang J, Jiang L-Q, Spinetti G, Pintus G, Monticone R, Kolodgie FD, Virmani R, Lakatta EG (2007). Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall. Hypertension, 50:219-27.
31. Nosaka H, Tanaka H, Watanabe I, Sato M, Matsuda M (2003). Influence of regular exercise on age-related changes in arterial elasticity: mechanistic insights from wall compositions in rat aorta. Can J Appl Physiol, 28:204-12.
32. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG (2004). Rat Aortic MCP-1 and Its Receptor CCR2 Increase With Age and Alter Vascular Smooth Muscle Cell Function. Arterioscler Thromb Vasc Biol, 24:1397-1402.
33. Wang M, Lakatta EG (2002). Altered Regulation of Matrix Metalloproteinase-2 in Aortic Remodeling During Aging. Hypertension, 39:865-873.
34. Wang M, Zhang J, Spinetti G, Jiang LQ, Monticone R, Zhao D, Cheng L, Krawczyk M, Talan M, Pintus G, Lakatta EG (2005). Angiotensin II Activates Matrix Metalloproteinase Type II and Mimics Age-Associated Carotid Arterial Remodeling in Young Rats. Am J Pathol, 167:1429-42.
35. Qiu H, Depre C, Ghosh K, Resuello RG, Natividad FF, Rossi F, Peppas A, Shen YT, Vatner DE, Vatner SF (2007). Mechanism of Gender-Specific Differences in Aortic Stiffness With Aging in Nonhuman Primates. Circulation, 116:669-76.
36. Schulze-Bauer CAJ, Regitnig P, Holzapfel GA (2002). Mechanics of the human femoral adventitia including the high-pressure response. Am J Physiol Heart Circ Physiol, 282:H2427-40.
37. Qiu H, Tian B, Resuello RG, Natividad FF, Peppas A, Shen YT, Vatner DE, Vatner SF, Depre C (2007). Sex-specific regulation of gene expression in the aging monkey aorta. Physiol Genomics, 29:169-80.
38. Cox RH (1983). Age-related changes in arterial wall mechanics and composition of NIA Fischer rats. Mech Ageing Dev, 23:21-36.
39. Behmoaras J, Slove S, Seve S, Vranckx R, Sommer P, Jacob MP (2008). Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta. Rejuvenation Res, 11:883-9.
40. Bedell-Hogan D, Trackman P, Abrams W, Rosenbloom J, Kagan H (1993). Oxidation, cross-linking, and insolubilization of recombinant tropoelastin by purified lysyl oxidase. J Biol Chem, 268:10345-50.
41. Kothapalli CR, Ramamurthi A (2009). Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells. J Tissue Eng Regen Med, 3:655-61.
42. Halushka MK, Selvin E, Lu J, Macgregor AM, Cornish TC (2009). Use of human vascular tissue microarrays for measurement of advanced glycation endproducts. J Histochem Cytochem, 57:559-66.
43. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG (2001). Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker. Circulation, 104:1464-70.
44. 2 production promotes endothelial NFkB activation in aged rat arteries. Am J Physiol Heart Circ Physiol, 293:H37-47.
45. Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA (2009). Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol, 587:3271-85.
46. Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR (2009). B6D2F1 Mice Are a Suitable Model of Oxidative Stress-Mediated Impaired Endothelium-Dependent Dilation With Aging. J Gerontol A Biol Sci Med Sci, 64A:9-20.
47. Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K, Brigham K, Hooper WC, Alexander RW, Jones DP, Quyyumi AA (2011). Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis, 218:90-5.
48. Klemm DJ, Majka SM, Crossno JT, Jr., Psilas JC, Reusch JEB, Garat CV (2011). Reduction of Reactive Oxygen Species Prevents Hypoxia-induced CREB Depletion in Pulmonary Artery Smooth Muscle Cells. J Cardiovasc Pharmacol, 58:181-91.
49. Lesniewski LA, Durrant JR, Connell ML, Folian BJ, Donato AJ, Seals DR (2011). Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor κB and Forkhead Box O Phosphorylation. J Gerontol A Biol Sci Med Sci, 66A:409-18.
50. Vaitkevicius PV, Fleg JL, Engel JH, O'Connor FC, Wright JG, Lakatta LE, Yin FC, Lakatta EG (1993). Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation, 88:1456-62.
51. Tanaka H, DeSouza CA, Seals DR (1998). Absence of Age-Related Increase in Central Arterial Stiffness in Physically Active Women. Arterioscler Thromb Vasc Biol, 18:127-32.
52. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR (2000). Aging, Habitual Exercise, and Dynamic Arterial Compliance. Circulation 102:1270-5.
53. Clempus RE, Sorescu D, Dikalova AE, Pounkova L, Jo P, Sorescu GP, Lassegue B, Griendling KK (2007). Nox4 Is Required for Maintenance of the Differentiated Vascular Smooth Muscle Cell Phenotype. Arterioscler Thromb Vasc Biol, 27:42-8.
54. Machha A, Schechter A (2011). Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr, 50:293-303.
55. Montenegro MF, Amaral JH, Pinheiro LC, Sakamoto EK, Ferreira GC, Reis RI, Marcal DMO, Pereira RP, Tanus-Santos JE (2011). Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. Free Radic Biol Med, 51:144-52.
56. Ataya B, Tzeng E, Zuckerbraun BS (2011). Nitrite-generated nitric oxide to protect against intimal hyperplasia formation. Trends Cardiovasc Med, 21:157-62.
57. Alef MJ, Vallabhaneni R, Carchman E, Morris SM, Shiva S, Wang Y, Kelley EE, Tarpey MM, Gladwin MT, Tzeng E, Zuckerbraun BS (2011). Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. J Clin Invest, 121:1646-56.
58. Miriyala S, Panchatcharam M, Rengarajulu P (2007). Cardioprotective effects of curcumin. Adv Exp Med Biol, 595:359-77.
59. Majithiya JB, Balaraman R (2005). Time-Dependent Changes in Antioxidant Enzymes and Vascular Reactivity of Aorta in Streptozotocin-Induced Diabetic Rats Treated With Curcumin. J Cardiovasc Pharmacol, 46:697-705.
60. Nakmareong S, Kukongviriyapan U, Pakdeechote P, Donpunha W, Kukongvirilyapan V, Kongylingyoes B, Sompamit K, Phisalaphong C (2011). Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficency. Hypertension Res, 383:519-29.
61. Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S (2010). Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med, 10:57.
62. Cheng AL, Hsu C, Lin J, Hsu MM, Ho Yf, Shen TS, Ko JY, Lin JT, Lin Br, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang TJ, Tsai CC, Hsieh CY (2001). Phase I clincial trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res, 21:2895-900.
63. Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, Seals DR (2012). Curcumin amerliorates arterial dysfunction and oxidative stress with aging. Exp Gerontol, In Press DOI: 10.1016/j.exger.2012.10.008.
64. Skilton MR, Boussel L, Bonnet F, Bernard S, Douek PC, Moulin P, Serusciat A (2011). Carotid intima-media and adventitial thickening: Comparison of new and established ultrasound and magnetic resonance imaging techniques. Atherosclerosis, 215:405-10.