Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells

Journal of Cardiovascular Pharmacology

Volumn 58, Issue 2, 2011, Pages 181-191

  Klemm, Dwight J ^a   Majka, Susan M ^a   Crossno Jr , Joseph T ^a   Psilas, John C ^a   Reusch, Jane Eb ^a   Garat, Chrystelle V ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

CREB; hypoxia; reactive oxygen species; vascular remodeling; vascular smooth muscle cells

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROGEN PEROXIDE; LINSIDOMINE; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ANIMALS; ANOXIA; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL HYPOXIA; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; HYPERTENSION, PULMONARY; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, INBRED WKY; RNA, SMALL INTERFERING;

EID: 80051783098     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31821f2773     Document Type: Article

References (37)

1. Mandegar M, Fung YC, Huang W, et al. Cellular and molecular mechanisms of pulmonary vascular remodeling: Role in the development of pulmonary hypertension. Microvasc Res. 2004;68:75-103.
2. Schultz K, Fanburg BL, Beasley D. Hypoxia and hypoxia-inducible factor-1 alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;290:H2528-H2534.
3. Perkett EAD, Badesch B, Roessler MK, et al. Insulin-like growth factor-1 and pulmonary hypertension induced by continuous air embolism in sheep. Am Rev Respir Cell Mol Biol. 1992;6:82-87.
4. Fanburg B, Lee SL. A role for the serotonin transporter in hypoxiainduced pulmonary hypertension. J Clin Invest. 2000;105:1521-1523.
5. Hassoun PM, Thappa V, Landman MJ, et al. Endothelin 1: Mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med. 1992;199:165-170.
6. Elmedal B, de Dam MY, Mulvany MJ, et al. The superoxide dismutase mimetic, Tempol, blunts right ventricular hypertrophy in chronic hypoxic rats. Br J Pharmacol. 2004;141:105-113.
7. Hoshikawa Y, Ono S, Suzuki S, et al. Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol. 2001;90:1299-1306.
8. LachmanováV, HnilickováO, PovúsilováV, et al. N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia. Life Sci. 2005;77:175-182.
9. Brennan LA, Steinhorn RH, Wedgwood S, et al. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: A role for NADPH oxidase. Circ Res. 2003;92:683-691.
10. Jankov RP, Kantores C, Pan J, et al. Contribution of xanthine oxidasederived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats. Am J Lung Cell Mol. 2008;294:L233-L245.
11. Marshall C, Mamary AJ, Verhoeven AJ, et al. Pulmonary artery NADPHoxidase is activated in hypoxic pulmonary vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br J Pharmacol. 1996;119:917-930.
12. Liu JQ, Zelko IN, Erbynn EM, et al. Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidase (gp91phox). Am J Physiol Lung Cell Mol Physiol. 2006;290:L2-L10.
13. Nisbet RE, Graves AS, Kleinhenz DJ, et al. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Am J Respir Cell mol Biol. 2009;40:601-609.
14. Garat CV, Fankel D, Erickson PF, et al. Platelet-derived growth factor BB induces nuclear export and proteosomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol. 2006;26:4934-4948.
15. Jambal P, Masterson S, Nesterova A, et al. Cytokine-mediated downregulation of the transcription factor cAMP-response element-binding protein in pancreatic beta cells. J Biol Chem. 2003;278:23055-23065.
16. Pugazhenti S, Nesterova A, Sable C, et al. Akt/protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 2000;275:10761-10766.
17. Watson PA, Vinson C, Nesterova A, et al. Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles. Endocrinology. 2002; 143:2922-2929.
18. Stevens T, Morris K, McMurtry IF, et al. Pulmonary and systemic vascular responsiveness to TNF-alpha in conscious rats, J Appl Pysiol. 1993;74: 1905-1910.
19. Klemm DJ, Watson PA, Frid MG, et al. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem. 2001;276:46132-46141.
20. Hogg N, Darley-Usmar VM, Wilson MT, et al. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J. 1992;281:419-424.
21. Ozgen N, Guo J, Gertsberg Z, et al. Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation. Mol Pharmacol. 2009;76:896-902.
22. Ushio-Fukai M, Alexander RW, Akers M, et al. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem. 1999;274:22699-22704.
23. Shimizu H, Hirose Y, Nishijima F, et al. ROS and PDGF-{beta} receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration. Am J Physiol Cell Physiol. 2009;297:389-396.
24. Lei H, Kazlauskas A. Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem. 2009;284:6329-6336.
25. Kappert K, Sparwel J, Sandin A, et al. Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCc and in restenosis. Arterioscler Thromb Vasc Biol. 2006;26:2644-2651.
26. Leonard MO, Howell K, Madden SF, et al. Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med. 2008;178:977-983.
27. Tucker A, McMurtry IF, Reeves JT, et al. Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. Am J Physiol. 1975;228:762-767.
28. Krishna MC, Russo A, Mitchell JB, et al. Do nitroxide antioxidants act as scavengers of O2- or SOD mimics? J Biol Chem. 1996;271:26026-26031.
29. Lavina B, Gracia-Sancho J, Rodriguez-Vilarrupla A, et al. Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension. Gut. 2009;58:118-125.
30. Elmarakby AA, Williams JM, Imig JD, et al. Synergistic actions of enalapril and Tempol during chronic angiotensin II-induced hypertension. Vascul Pharmacol. 2007;46:144-151.
31. Karmeli F, Eliakim R, Okon E, et al. A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. Gut. 1995;37: 386-393.
32. Gelvan D, Saltman P, Powell SR. Cardiac reperfusion damage prevented by a nitroxide free-radical. Proc Natl Acad Sci USA. 1991;88:4680-4684.
33. Hyvelin JM, Howell K, Nichol A, et al. Inhibition of Rho kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res. 2005;97:185-191.
34. Van Suylen RJ, Smits JF, Daemen MJ. Pulmonary artery remodeling differs from hypoxia- and monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med. 1998;157:1423-1428.
35. Clozel JP, Saunier C, Hartemann D, et al. Effects of cilazapril, a novel angiotensin converting enzyme inhibitor, on the structure of pulmonary arteries exposed to chronic hypoxia. J Cardiovasc Pharmacol. 1991;17: 36-40.
36. Crossno JT Jr, Garat CV, Reusch JE, et al. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2007;292:L885-L897.
37. Nagaoka T, Fagan KA, Gebb SA, et al. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med. 2005;171:494-499.