Integrative analysis of mRNA and miRNA array data reveals the suppression of retinoic acid pathway in regulatory T cells of Graves' disease

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 12, 2014, Pages E2620-E2627

  Wang, Zhe ^a   Fan, Xiaohua ^a   Zhang, Rongrong ^a   Lin, Zongwei ^c   Lu, Ting ^a   Bai, Xue ^a   Li, Wenchao ^a   Zhao, Jiajun ^a   Zhang, Qunye ^b,c  

^a SHANDONG UNIVERSITY   (China)

^b THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; RETINOIC ACID;

ADULT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; REGULATORY T LYMPHOCYTE; UBIQUITINATION; AGONISTS; BLOOD; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ADULT; FEMALE; GRAVES DISEASE; HUMANS; MALE; MICROARRAY ANALYSIS; MICRORNAS; MIDDLE AGED; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRETINOIN;

EID: 84916600750     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1883     Document Type: Article

References (36)

1. Weetman AP. Graves' disease. N Engl J Med. 2000;343(17):1236-1248.
2. Wang Z, Zhang Q, Lu J, et al. Identification of outer membrane porin f protein of Yersinia enterocolitica recognized by antithyrotopin receptor antibodies in Graves' disease and determination of its epitope using mass spectrometry and bioinformatics tools. J Clin Endocrinol Metab. 2010;95(8):4012-4020.
3. Bilate AM, Lafaille JJ. Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol. 2012;30:733-758.
4. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 2007;445(7129):766-770.
5. Glick AB, Wodzinski A, Fu P, Levine AD, Wald DN. Impairment of regulatory T-cell function in autoimmune thyroid disease. Thyroid. 2013;23(7):871-878.
6. Ellis JS, Wan X, Braley-Mullen H. Transient depletion of CD4+CD25+ regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice. Immunology. 2013;139(2):179-186.
7. Mao C, Wang S, Xiao Y, et al. Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol. 2011;186(8):4734-4743.
8. Cobb BS, Hertweck A, Smith J, et al. A role for Dicer in immune regulation. J Exp Med. 2006;203(11):2519-2527.
9. Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E. Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol. 2009;182(5):2578-2582.
10. De Santis G, Ferracin M, Biondani A, et al. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol. 2010;226(1-2):165-171.
11. Liu R, Ma X, Xu L, et al. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. J Clin Endocrinol Metab. 2012;97(6):E968-E972.
12. Bernecker C, Halim F, Lenz L, et al. microRNA Expressions in CD4+ and CD8+ T-cell Subsets in Autoimmune Thyroid Diseases. Exp Clin Endocrinol Diabetes. 2014;122(2):107-112.
13. Yamada H, Itoh M, Hiratsuka I, Hashimoto S. Circulating microRNAs in autoimmune thyroid diseases. Clin Endocrinol (Oxf). 2014;81(2):276-81.
14. Bernecker C, Lenz L, Ostapczuk MS, et al. MicroRNAs miR-146a1, miR-155-2, and miR-200a1 are regulated in autoimmune thyroid diseases. Thyroid. 2012;22(12):1294-1295.
15. Wang G, Zhong A, Wang S, Dong N, Sun Z, Xia J. Retinoic acid attenuates acute heart rejection by increasing regulatory T cell and repressing differentiation of Th17 cell in the presence of TGF-β. Transpl Int. 2010;23(10):986-997.
16. Konta T,XuQ, Furusu A,NakayamaK, KitamuraM. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001;276(16):12697-12701.
17. Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117(14):3921-3928.
18. Friedman RC, Farh KK, Burge CB, Bartel DP. Most Mammalian mRNAs Are Conserved Targets of MicroRNAs. Genome Research. 2009;19(1):92-105.
19. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol. 2005;3(7):e264.
20. St-Pierre C, Brochu S, Vanegas JR, Dumont-Lagacé M, Lemieux S, Perreault C. Transcriptome sequencing of neonatal thymic epithelial cells. Sci Rep. 2013;3:1860.
21. Muindi JR, Frankel SR, Huselton C, et al. Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia. Cancer Res. 1992;52(8):2138-2142.
22. Hu Y, Tian W, Zhang LL, et al. Function of regulatory T-cells improved by dexamethasone in Graves' disease. Eur J Endocrinol. 2012;166(4):641-646.
23. Marazuela M, García-López MA, Figueroa-Vega N, et al. RegulatoryTcells inhumanautoimmune thyroid disease. J Clin Endocrinol Metab. 2006;91(9):3639-3646.
24. Hall JA, Grainger JR, Spencer SP, Belkaid Y. The role of retinoic acid in tolerance and immunity. Immunity. 2011;35(1):13-22.
25. Zhou R, Horai R, Mattapallil MJ, Caspi RR. Anew look at immune privilege of the eye: Dual role for the vision-related molecule retinoic acid. J Immunol. 2011;187(8):4170-4177.
26. Mucida D, Park Y, Kim G, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007;317(5835):256-260.
27. Nolting J, Daniel C, Reuter S, et al. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009;206(10):2131-2139.
28. Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, and Sawada N. Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis. Mol Pharmacol. 2007;71:250-258.
29. Zunino SJ, Storms DH, and Stephensen CB. Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. J Nutr. 2007;137:1216-1221.
30. Miyagawa N, Homma T, Kagechika H, Shudo K, and Nagai H. Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease. Pharmacology. 2003;67:21-31.
31. Reifen R, Nur T, Ghebermeskel K, Zaiger G, Urizky R, Pines M. Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-kappaB and collagen formation. J Nutr. 2002;132:2743-2747.
32. Mi JQ, Li JM, Shen ZX, Chen SJ, Chen Z. How to manage acute promyelocytic leukemia. Leukemia. 2012;26(8):1743-1751.
33. Njar VC, Gediya L, Purushottamachar P, et al. Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg Med Chem. 2006;14(13):4323-4340.
34. Chen Z, Luo X, Lu Y, et al. Ubiquitination signals critical to regulatory T cell development and function. Int Immunopharmacol. 2013;16(3):348-352.
35. Harada Y, Harada Y, Elly C, et al. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med. 2010;207(7):1381-1391.
36. Yu X, Rollins D, Ruhn KA, et al. TH17 cell differentiation is regulated by the circadian clock. Science. 2013;342(6159):727-730.