Association of obesity with leukocyte count in obese individuals without metabolic syndrome

Diabetes and Metabolic Syndrome: Clinical Research and Reviews

Volumn 8, Issue 4, 2014, Pages 197-204

  Ryder, Elena ^a   Diez Ewald, María ^a   Mosquera, Jesús ^a   Fernández, Erika ^a   Pedreañez, Adriana ^a   Vargas, Renata ^a   Peña, Caterina ^a   Fernández, Nelson ^a  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

Author keywords

Inflammation; Insulin resistance; Leukocytes; Obesity

Indexed keywords

CHOLESTEROL; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; HEMOGLOBIN A1C PROTEIN, HUMAN; LIPID;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FATTY LIVER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LEUKOCYTE COUNT; LIPID BLOOD LEVEL; LYMPHOCYTE COUNT; NEUTROPHIL LYMPHOCYTE RATIO; OBESITY; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; ARTERIAL PRESSURE; BLOOD; BODY WEIGHT; FEMALE; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; NEUTROPHIL; PATHOPHYSIOLOGY;

ADULT; ARTERIAL PRESSURE; BLOOD GLUCOSE; BODY MASS INDEX; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; LEUKOCYTE COUNT; LIPIDS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NEUTROPHILS; OBESITY; THINNESS;

EID: 84916600530     PISSN: 18714021     EISSN: 18780334     Source Type: Journal    
DOI: 10.1016/j.dsx.2014.09.002     Document Type: Article

References (34)

1. M.A. Cornier, D. Dabelea, T.L. Hernandez, R.C. Lindstrom, A.J. Steig, and N.R. Stob The metabolic syndrome Endocr Rev 29 7 2008 777 822 10.1210/er.2008-0024
2. G.M. Reaven The insulin resistance syndrome: definition and dietary approaches to treatment Annu Rev Nutr 25 4 2005 391 406
3. O. Osborn, and J.M. Olefsky The cellular and signaling networks linking the immune system and metabolism in disease Nat Med 18 3 2012 363 374 10.1038/nm.2627
4. G.R. Romeo, J. Lee, and S.E. Shoelson Metabolic syndrome, insulin resistance, and roles of inflammation - mechanisms and therapeutic targets Arterioscler Thromb Vasc Biol 32 8 2012 1771 1776 10.1161/ATVBAHA.111.241869
5. Y. Watanabe, Y. Nagai, and K. Takatsu Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance Nutrients 5 9 2013 3757 3778 10.3390/nu5093757
6. G. Twig, A. Afek, A. Shamiss, E. Derazne, D. Tzur, and B. Gordon White blood cells count and incidence of type 2 diabetes in young men Diabetes Care 36 2 2013 276 282 10.2337/dc11-2298
7. C. Lorenzo, A.J. Hanley, and S.M. Haffner Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study Diabetología 57 2014 83 92 10.1007/s00125-013-3080-0
8. E. Ryder, V. Mijac, E. Fernández, N. Palazzi, M.C. Morales, and L. Connell Esteatosis hepática, grasa visceral y alteraciones metabólicas en individuos con sobrepeso/obesidad aparentemente sanos Invest Clin 55 2014 3 14
9. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 7 1985 412 419
10. G. Buccini, and D.L. Wolftbal Valores de corte para indices de insulinoresistencia, insulinosensibilidad e insulinosecrecion derivados de la formula HOMA y del programa HOMAZ. Interpretación de los datos Rev Argent Endocrinol Metab 45 2008 3 21
11. M.L. Garmedia, L. Lera, H. Sanchez, R. Vauy, and C. Albala Homeostasis model assessment (HOMA) values in Chilean elderly subjects Rev Med Chile 137 11 2009 1409 1416 /S0034-98872009001100001
12. T. Pecht, A. Gutman-Tirosh, N. Bashan, and A. Rudich Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesitysubphenotypes in humans Obes Rev 15 4 2014 322 337 10.1111/obr.12133
13. J.B. Carvalheira, Y. Qiu, and A. Chawla Blood spotlight on leukocytes and obesity Blood 122 19 2013 3263 3267 10.1182/blood-2013-04-459446
14. A.J. Hanley, R. Retnakaran, Y. Qi, H.C. Gerstein, B. Perkins, and J. Raboud Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects Clin Endocrinol Metab 94 10 2009 3824 3832 10.1210/jc.2009-0719
15. E. Gkrania-Klotsas, Z. Ye, A.J. Cooper, S.J. Sharp, R. Luben, and M.L. Biggs Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies PLoS ONE 5 10 2010 e13405 10.1371/journal.pone.0013405
16. C.T. Lee, S.B. Harris, R. Retnakaran, H.C. Gerstein, B.A. Perkins, and B. Zinman White blood cell subtypes, insulin resistance and β-cell dysfunction in high-risk individuals - the PROMISE cohort Clin Endocrinol (Oxf) 2013 10.1111/cen.12390
17. H. Kaur, B. Adams-Huet, G. Smith, and I. Jialal Increased neutrophil count in nascent metabolic syndrome Metab Syndr Relat Disord 11 2 2013 128 131 10.1089/met.2012.0179
18. T. Annadurai, P.A. Thomas, and P. Geraldine Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin-nicotinamide-induced experimental diabetes mellitus Free Radic Res 47 10 2013 793 803 10.3109/10715762.2013.823643
19. J.E. Pessin, and A.R. Saltiel Signaling pathways in insulin action: molecular targets of insulin resistance J Clin Invest 106 2 2000 165 169
20. K.W. Cho, D.L. Morris, and C.N. Lumeng Flow cytometry analyses of adipose tissue macrophages Methods Enzymol 537 2014 297 314 10.1016/B978-0-12-411619-1.00016-1
21. E. Jiang, X.D. Perrard, D. Yang, I.M. Khan, J.L. Perrard, and C.W. Smith Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue Arterioscler Thromb Vasc Biol 34 1 2014 34 43 10.1161/ATVBAHA.113.302077
22. D.A. Winer, S. Winer, M.H. Chng, L. Shen, and E.G. Engleman B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance Cell Mol Life Sci 71 6 2014 1033 1043 10.1007/s00018-013-1486-y
23. E. Oda, R. Kawai, and Y. Aizawa Lymphocyte count was significantly associated with hyper-LDL cholesterolemia independently of high-sensitivity C-reactive protein in apparently healthy Japanese Heart Vessels 27 4 2012 377 383 10.1007/s00380-011-0157-x
24. W.S. Shim, H.J. Kim, E.S. Kang, C.W. Ahn, S.K. Lim, and H.C. Lee The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients Diabetes Res Clin Pract 73 3 2006 284 291
25. E. Barg, J. Szopa, K.A. Pesz, and K. Gąsiorowski Indices of insulin resistance and dyslipidemia are correlated with lymphocyte proneness to apoptosis in obese or overweight low birth weight children Horm Res Paediatr 79 5 2013 293 299 10.1159/000351012
26. E. Ryder, A. Pedreanez, R. Vargas, C. Pena, E. Fernnadez, and M. Diez-Ewald Increased proinflammatory markers and lipoperoxidation in obese individuals: inicial inflammatory events? Diab Met Syndr: Clin Res Rev 2014 10.1016/j.dsx.2014.04.022
27. R.R. Gerner, V. Wieser, A.R. Moschen, and H. Tilg Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver Can J Physiol Pharmacol 91 11 2013 867 872 10.1139/cjpp-2013-0050
28. A.J. Van Oostrom, T.P. Sijmonsma, T.J. Rabelink, B.S. Van Asbeck, and M.C. Cabezas Postprandial leukocyte increase in healthy subjects Metabolism 52 2 2003 199 202
29. V. Catalán, J. Gómez-Ambrosi, A. Rodríguez, B. Ramírez, F. Rotellar, and V. Valentí Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity Eur J Nutr 52 6 2013 1587 1595 10.1007/s00394-012-0464-8
30. J. Nijhuis, S.S. Rensen, Y. Slaats, Dielen F.M. van, W.A. Buurman, and J.W. Greve Neutrophil activation in morbid obesity, chronic activation of acute inflammation Obesity (Silver Spring) 17 11 2009 2014 2018 10.1038/oby.2009.113
31. M. Reyes, C. Quintanilla, R. Burrows, E. Blanco, M. Cifuentes, and S. Gahagan Obesity is associated with acute inflammation in a sample of adolescents Pediatr Diabetes 2014 10.1111/pedi.12129
32. R. Xu, H. Huang, Z. Zhang, and F.S. Wang The role of neutrophils in the development of liver diseases Cell Mol Immunol 11 3 2014 224 231 10.1038/cmi.2014.2
33. S.S. Rensen, Y. Slaats, J. Nijhuis, A. Jans, V. Bieghs, and A. Driessen Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis Am J Pathol 175 4 2009 1473 1482 10.2353/ajpath.2009.080999
34. N. Alkhouri, G. Morris-Stiff, C. Campbell, R. Lopez, T.A. Tamimi, and L. Yerian Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease Liver Int 32 2 2012 297 302 10.1111/j.1478-3231.2011.02639.x