L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

British Journal of Haematology

Volumn 167, Issue 4, 2014, Pages 524-528

  Narla, Anupama ^a,b   Payne, Elspeth M ^c,d   Abayasekara, Nirmalee ^b   Hurst, Slater N ^b   Raiser, David M ^b   Look, A Thomas ^b   Berliner, Nancy ^b   Ebert, Benjamin L ^b   Khanna Gupta, Arati ^b  

^a LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Camden and Islington National Health Service Foundation Trust   (United Kingdom)

Author keywords

Diamond blackfan anaemia; Haematopoiesis; Leucine; TP53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; LEUCINE; PROTEIN P53; RIBOSOME PROTEIN; ZEBRAFISH PROTEIN;

5Q- SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACKFAN DIAMOND ANEMIA; CDKN1A GENE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; EMBRYO; ERYTHROCYTE COUNT; ERYTHROPOIESIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN SYNTHESIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TP53 GENE; UPREGULATION; ZEBRA FISH; ANEMIA, DIAMOND-BLACKFAN; ANEMIA, MACROCYTIC; ANIMAL; CHROMOSOME 5; CHROMOSOME DELETION; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; PATHOLOGY;

ANEMIA, DIAMOND-BLACKFAN; ANEMIA, MACROCYTIC; ANIMALS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; HUMANS; LEUCINE; RIBOSOMAL PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH PROTEINS;

EID: 84916239201     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13069     Document Type: Article

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