Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro

Molecular Medicine Reports

Volumn 11, Issue 1, 2015, Pages 133-142

  Yang, Wengang ^a   Zheng, Hui ^a   Wang, Yongyi ^a   Lian, Feng ^a   Hu, Zhenglei ^a   Xue, Song ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cardiomyocyte like cells; Differentiation; Mesenchymal stem cells; Myocardial ischemia; Nesprin 1 protein

Indexed keywords

ALPHA ACTININ; BETA1 INTEGRIN; DESMIN; MEMBRANE PROTEIN; MESSENGER RNA; NESPRIN 1; THY 1 ANTIGEN; TROPONIN I; UNCLASSIFIED DRUG; ACTININ; AZACITIDINE; MEMBRANE ANTIGEN; NERVE PROTEIN; NUCLEAR PROTEIN; SYNE1 PROTEIN, RAT; TROPONIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; HEART INFARCTION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACOTOMY; WESTERN BLOTTING; ANIMAL; CULTURE TECHNIQUE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY;

RATTUS;

ACTININ; ANIMALS; ANTIGENS, SURFACE; AZACITIDINE; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS; RNA, MESSENGER; TROPONIN C;

EID: 84916232918     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2754     Document Type: Article

References (37)

1. Zhang Q, Skepper JN, Yang F, et al: Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J Cell Sci 114: 4485-4498, 2001.
2. Apel ED, Lewis RM, Grady RM and Sanes JR: Syne-1, a dystrophin-and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem 275: 31986-31995, 2000.
3. Lammerding J, Schulze PC, Takahashi T, et al: Lamin A/C defciency causes defective nuclear mechanics and mechano-transduction. J Clin Invest 113: 370-378, 2004.
4. Zhang Q, Ragnauth CD, Skepper JN, et al: Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J Cell Sci 118 (Pt 4): 673-687, 2005.
5. Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147, 1999.
6. Minguell JJ, Erices A and Conget P: Mesenchymal stem cells. Exp Biol Med (Maywood) 226: 507-520, 2001.
7. Devine SM: Mesenchymal stem cells: will they have a role in the clinic? J Cell Biochem Suppl 38: 73-79, 2002.
8. Nagaya N, Fujii T, Iwase T, et al: Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 287: H2670-H2676, 2004.
9. Miyahara Y, Nagaya N, Kataoka M, et al: Monolayered mesen-chymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12: 459-465, 2006.
10. Nagaya N, Kangawa K, Itoh T, et al: Transplantation of mesen-chymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 112: 1128-1135, 2005.
11. Chedrawy EG, Wang JS, Nguyen DM, et al: Incorporation and integration of implanted myogenic and stem cells into native myocardial fbers: anatomic basis for functional improvements. J Thorac Cardiovasc Surg 124: 584-590, 2002.
12. Min J Y, Sandmann S, Meissner A, et al: Differential effects of mibefradil, verapamil, and amlodipine on myocardial function and intracellular Ca(2+) handling in rats with chronic myocardial infarction. J Pharmacol Exp Ther 291: 1038-1044, 1999.
13. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
14. Martina JD, Simmons C, Jukic DM.High-defnition hema-toxylin and eosin staining in a transition to digital pathology.J Pathol Inform 2: 45, 2011.
15. Friedenstein AJ, Petrakova K V, Kurolesova AI, et al: Heterotopic transplants of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6: 230-247, 1968.
16. Dennis JE and Charbord P: Origin and differentiation of human and murine stroma. Stem Cells 20: 205-214, 2002.
17. Campagnoli C, Roberts IA, Kumar S, et al: Identifcation of mesenchymal stem/progenitor cells in human frst-trimester fetal blood, liver, and bone marrow. Blood 98: 2396-2402, 2001.
18. Martin DR, Cox NR, Hathcock TL, et al: Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow. Exp Hematol 30: 879-886, 2002.
19. Wakitani S, Saito T and Caplan AI: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18: 1417-1426, 1995.
20. Dominici M, Le Blanc K, Mueller I, et al: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317, 2006.
21. Xu W, Zhang X, Qian H, et al: Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med (Maywood) 229: 623-631, 2004.
22. Makino S, Fukuda K, Miyoshi S, et al: Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103: 697-705, 1999.
23. Toma C, Pittenger MF, Cahill KS, et al: Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105: 93-98, 2002.
24. Yoon J, Min BG, Kim YH, et al: Differentiation, engraftment and functional effects of pre-treated mesenchymal stem cells in a rat myocardial infarct model. Acta Cardiol 60: 277-284, 2005.
25. Xie XJ, Wang JA, Cao J and Zhong X: Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin 27: 1153-1158, 2006.
26. Forte G, Minieri M, Cossa P, et al: Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 24: 23-33, 2006.
27. Li W, Ma N, Ong LL, et al: Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 25: 2118-2127, 2007
28. Hu X, Wang J, Chen J, et al: Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg 31: 438-443, 2007
29. Mislow JM, Holaska JM, Kim MS, et al: Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett 525: 135-140, 2002.
30. Mislow JM, Kim MS, Davis DB, et al: Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J Cell Sci 115 (Pt 1): 61-70, 2002.
31. Starr DA and Han M: Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science 298: 406-409, 2002.
32. Starr DA and Han M: ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci 116 (Pt 2): 211-216, 2003.
33. Gough LL, Fan J, Chu S, et al: Golgi localization of Syne-1. Mol Biol Cell 14: 2410-2424, 2003.
34. Zhang Q, Ragnauth C, Greener MJ, et al: The nesprins are giant actin-binding proteins, orthologous to Drosophila melano-gaster muscle protein MSP-300. Genomics 80: 473-481, 2002.
35. Pare GC, Easlick JL, Mislow JM, et al: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res 303: 388-399, 2005.
36. Puckelwartz MJ, Kessler EJ, Kim G, et al: Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol 48: 600-608, 2010.
37. Randles KN, Lam le T, Sewry CA, et al: Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Dev Dyn 239: 998-1009, 2010.