The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300

Genomics

Volumn 80, Issue 5, 2002, Pages 473-481

  Zhang, Qiuping ^a   Ragnauth, Cassandra ^a   Greener, Marc J ^b   Shanahan, Catherine M ^a   Roberts, Roland G ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Actin binding proteins; Dystrophin; Emerin; Lamin; MSP 300; Muscular dystrophy; Nesprin; Nuclear envelope; Sarcomere; Spectrin repeat; SYNE 1

Indexed keywords

ACTIN BINDING PROTEIN; ISOPROTEIN; MUSCLE PROTEIN; PROTEIN MSP 300; PROTEIN NESPRIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; MSP 300 PROTEIN, DROSOPHILA; NERVE PROTEIN; NUCLEAR PROTEIN; SYNE1 PROTEIN, HUMAN; SYNE2 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DROSOPHILA MELANOGASTER; GENETIC DISORDER; HEART MUSCLE; MUSCLE DEVELOPMENT; MUTANT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SARCOMERE; SKELETAL MUSCLE; AMINO ACID SEQUENCE; ANIMAL; CELL FRACTIONATION; CHEMISTRY; CYTOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NEMATODE; PHYLOGENY; SEQUENCE ALIGNMENT;

DROSOPHILA MELANOGASTER; MELANOGASTER; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUSCLE PROTEINS; MUSCLE, SKELETAL; NEMATODA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHYLOGENY; PROTEIN ISOFORMS; SEQUENCE ALIGNMENT; SUBCELLULAR FRACTIONS;

EID: 0036429266     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0888-7543(02)96859-X     Document Type: Article

References (33)

1. Koenig, M., Monaco, A. P., and Kunkel, L. M. (1988). The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell 53: 219-226.
2. Delaunay, J., et al. (1996). Molecular genetics of hereditary elliptocytosis and hereditary spherocytosis. Ann. Genet. 39: 209-221.
3. Kaplan, J. M., et al. (2000). Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis. Nat. Genet. 24: 251-256.
4. Parkinson, N. J., et al. (2001). Mutant β-spectrin 4 causes auditory and motor neuropathies in quivering mice. Nat. Genet. 29: 61-65.
5. Brown, A., Bernier, G., Mathieu, M., Rossant, J., and Kothary, R. (1995). The mouse dys-tonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat. Genet. 10: 301-306.
6. Love, D. R., et al. (1989). An autosomal transcript in skeletal muscle with homology to dystrophin. Nature 339: 55-58.
7. Roberts, R. G., et al. (1996). Characterization of DRP2, a novel human dystrophin homologue. Nat. Genet. 13: 223-226.
8. Roberts, R. G., and Bobrow, M. (1998). Dystrophins in vertebrates and invertebrates. Hum. Mol. Genet. 7: 589-595.
9. Okuda, T., et al. (1999). Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin. Biochem. Biophys. Res. Commun. 264: 568-574.
10. Leung, C. L., Sun, D., Zheng, M., Knowles, D. R., and Liem, R. K. (1999). Microtubule actin cross-linking factor (MACF): A hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons. J. Cell Biol. 147: 1275-1286.
11. Sun, Y., et al. (1999). Molecular cloning and characterization of human trabeculin-α, a giant protein defining a new family of actin-binding proteins. J. Biol. Chem. 274: 33522-33530.
12. Lee, S., Harris, K. L., Whitington, P. M., and Kolodziej, P. A. (2000). Short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension. J. Neurosci. 20: 1096-1108.
13. Lee, S., and Kolodziej, P. A. (2002). Short Stop provides an essential link between F-actin and microtubules during axon extension. Development 129: 1195-1204.
14. Zhang, Q., et al. (2001). Nesprins: A novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J. Cell Sci. 114: 4485-4498.
15. Apel, E. D., Lewis, R. M., Grady, R. M., and Sanes, J. R. (2000). Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J. Biol. Chem. 275: 31986-31995.
16. Mislow, J. M., Kim, M. S., Davis, D. B., and McNally, E. M. (2002). Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J. Cell. Sci. 115: 61-70.
17. Mislow, J., et al. (2002). Nesprin-1α self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 525: 135.
18. Rosenberg-Hasson, Y., Renert-Pasca, M., and Volk, T. (1996). A Drosophila dystrophin-related protein, MSP-300, is required for embryonic muscle morphogenesis. Mech. Dev. 60: 83-94.
19. Volk, T. (1992). A new member of the spectrin superfamily may participate in the formation of embryonic muscle attachments in Drosophila. Development 116: 721-730.
20. Mosley-Bishop, K. L., Li, Q., Patterson, L., and Fischer, J. A. (1999). Molecular analysis of the klarsicht gene and its role in nuclear migration within differentiating cells of the Drosophila eye. Curr. Biol. 9: 1211-1220.
21. Ahn, A. H., and Kunkel, L. M. (1993). The structural and functional diversity of dystrophin. Nat. Genet. 3: 283-291.
22. Stuart, J. J., Brown, S. J., Beeman, R. W., and Denell, R. E. (1991). A deficiency of the homeotic complex of the beetle Tribolium. Nature 350: 72-74.
23. Fraser, A. G., et al. (2000). Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-330.
24. Djinovic-Carugo, K., Young, P., Gautel, M., and Saraste, M. (1999). Structure of the α-actinin rod: Molecular basis for cross-linking of actin filaments. Cell 98: 537-546.
25. Sonnhammer, E. L., von Heijne, G., and Krogh, A. (1998). A hidden Markov model for predicting transmembrane helices in protein sequences. Proc. Int. Conf. Intell. Syst. Mol. Biol. 6: 175-182.
26. Rando, O. J., Zhao, K., and Crabtree, G. R. (2000). Searching for a function for nuclear actin. Trends Cell Biol. 10: 92-97.
27. Sasseville, A. M., and Langelier, Y. (1998). In vitro interaction of the carboxy-terminal domain of lamin A with actin. FEBS Lett. 425: 485-489.
28. Fairley, E. A., Riddell, A., Ellis, J. A., and Kendrick-Jones, J. (2002). The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype. J. Cell Sci. 115: 341-354.
29. Morris, G. E. (2001). The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy. Trends Mol. Med. 7: 572-577.
30. Lupas, A., Van Dyke, M., and Stock, J. (1991). Predicting coiled coils from protein sequences. Science 252: 1162-1164.
31. Schultz, J., Milpetz, F., Bork, P., and Ponting, C. P. (1998). SMART, a simple modular architecture research tool: Identification of signaling domains. Proc. Natl. Acad. Sci. USA 95: 5857-5864.
32. Sonnhammer, E. L., and Durbin, R. (1995). A dot-matrix program with dynamic threshold control suited for genomic DNA and protein sequence analysis. Gene 167: GC1-10.
33. Felsenstein, J. (1989). PHYLIP-Phylogeny Inference Package (Version 3.2). Cladistics 5: 164-166.