메뉴 건너뛰기




Volumn 11, Issue 2, 2015, Pages 1017-1024

MicroRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor γ

Author keywords

Hepatic stellate cells; Liver fibrosis; Microrna 34a; MicroRNA 34c; Peroxisome proliferator activated receptor

Indexed keywords

ACTA2 PROTEIN, HUMAN; ACTIN; MICRORNA; MIRN34 MICRORNA, HUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84916229794     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2846     Document Type: Article
Times cited : (52)

References (39)
  • 2
    • 35948964347 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis
    • Moreira RK: Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 131: 1728-1734, 2007.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1728-1734
    • Moreira, R.K.1
  • 3
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 4
    • 77955022405 scopus 로고    scopus 로고
    • Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
    • Wiggins JF, Ruffino L, Kelnar K, et al: Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 70: 5923-5930, 2010.
    • (2010) Cancer Res , vol.70 , pp. 5923-5930
    • Wiggins, J.F.1    Ruffino, L.2    Kelnar, K.3
  • 5
    • 84881276749 scopus 로고    scopus 로고
    • Role of microRNAs in the immune system, inflammation and cancer
    • Raisch J, Darfeuille-Michaud A and Nguyen HT: Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol 19: 2985-2996, 2013.
    • (2013) World J Gastroenterol , vol.19 , pp. 2985-2996
    • Raisch, J.1    Darfeuille-Michaud, A.2    Nguyen, H.T.3
  • 7
    • 84865255059 scopus 로고    scopus 로고
    • MicroRNA are central players in anti- and profibrotic gene regulation during liver fibrosis
    • Noetel A, Kwiecinski M, Elfimova N, Huang J and Odenthal M: microRNA are central players in anti- and profibrotic gene regulation during liver fibrosis. Front Physiol 3: 49, 2012.
    • (2012) Front Physiol , vol.3 , pp. 49
    • Noetel, A.1    Kwiecinski, M.2    Elfimova, N.3    Huang, J.4    Odenthal, M.5
  • 8
    • 84864666197 scopus 로고    scopus 로고
    • Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling
    • Katayama Y, Maeda M, Miyaguchi K, et al: Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling. Oncol Lett 4: 817-823, 2012.
    • (2012) Oncol Lett , vol.4 , pp. 817-823
    • Katayama, Y.1    Maeda, M.2    Miyaguchi, K.3
  • 9
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, et al: A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134, 2007.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3
  • 10
    • 84857624291 scopus 로고    scopus 로고
    • Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review
    • Chen F and Hu SJ: Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review. J Biochem Mol Toxicol 26: 79-86, 2012.
    • (2012) J Biochem Mol Toxicol , vol.26 , pp. 79-86
    • Chen, F.1    Hu, S.J.2
  • 11
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang P, Wiggins JF, Daige CL, et al: Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 19: 1116-1122, 2011.
    • (2011) Mol Ther , vol.19 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 12
    • 84872908276 scopus 로고    scopus 로고
    • MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1
    • Pang RT, Leung CO, Lee CL, et al: MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer 13: 25, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 25
    • Pang, R.T.1    Leung, C.O.2    Lee, C.L.3
  • 13
    • 84858632494 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo
    • Yan K, Gao J, Yang T, et al: MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One 7: e33778, 2012.
    • (2012) PLoS One , vol.7 , pp. e33778
    • Yan, K.1    Gao, J.2    Yang, T.3
  • 14
    • 77957259450 scopus 로고    scopus 로고
    • Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
    • Pogribny IP, Starlard-Davenport A, Tryndyak VP, et al: Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-1446, 2010.
    • (2010) Lab Invest , vol.90 , pp. 1437-1446
    • Pogribny, I.P.1    Starlard-Davenport, A.2    Tryndyak, V.P.3
  • 15
    • 79955065145 scopus 로고    scopus 로고
    • The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li WQ, Chen C, Xu MD, et al: The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J 278: 1522-1532, 2011.
    • (2011) FEBS J , vol.278 , pp. 1522-1532
    • Li, W.Q.1    Chen, C.2    Xu, M.D.3
  • 16
    • 61849096150 scopus 로고    scopus 로고
    • MiR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis
    • Guo CJ, Pan Q, Li DG, Sun H and Liu BW: miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis. J Hepatol 50: 766-778, 2009.
    • (2009) J Hepatol , vol.50 , pp. 766-778
    • Guo, C.J.1    Pan, Q.2    Li, D.G.3    Sun, H.4    Liu, B.W.5
  • 17
    • 79551541594 scopus 로고    scopus 로고
    • The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families
    • Murakami Y, Toyoda H, Tanaka M, et al: The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One 6: e16081, 2011.
    • (2011) PLoS One , vol.6 , pp. e16081
    • Murakami, Y.1    Toyoda, H.2    Tanaka, M.3
  • 18
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, Chivukula RR, O'Donnell KA, et al: Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137: 1005-1017, 2009.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'Donnell, K.A.3
  • 19
    • 1642524221 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    • Hazra S, Xiong S, Wang J, et al: Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279: 11392-11401, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 11392-11401
    • Hazra, S.1    Xiong, S.2    Wang, J.3
  • 20
    • 84884871131 scopus 로고    scopus 로고
    • Amplified inhibition of stellate cell activation pathways by PPAR-γ RAR and RXR agonists
    • Sharvit E, Abramovitch S, Reif S and Bruck R: Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. PLoS One 8: e76541, 2013.
    • (2013) PLoS One , vol.8 , pp. e76541
    • Sharvit, E.1    Abramovitch, S.2    Reif, S.3    Bruck, R.4
  • 21
    • 84879834562 scopus 로고    scopus 로고
    • Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection
    • Attia YM, Elalkamy EF, Hammam OA, Mahmoud SS and El-Khatib AS: Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection. Parasit Vectors 6: 199, 2013.
    • (2013) Parasit Vectors , vol.6 , pp. 199
    • Attia, Y.M.1    Elalkamy, E.F.2    Hammam, O.A.3    Mahmoud, S.S.4    El-Khatib, A.S.5
  • 22
    • 59449097794 scopus 로고    scopus 로고
    • Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor
    • Bruck R, Weiss S, Aeed H, Pines M, Halpern Z and Zvibel I: Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig Dis Sci 54: 292-299, 2009.
    • (2009) Dig Dis Sci , vol.54 , pp. 292-299
    • Bruck, R.1    Weiss, S.2    Aeed, H.3    Pines, M.4    Halpern, Z.5    Zvibel, I.6
  • 23
    • 84870704529 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: From bench to bedside
    • Zhang F, Kong D, Lu Y and Zheng S: Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside. Cell Mol Life Sci 70: 259-276, 2012.
    • (2012) Cell Mol Life Sci , vol.70 , pp. 259-276
    • Zhang, F.1    Kong, D.2    Lu, Y.3    Zheng, S.4
  • 24
    • 60549088679 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes proliferation and upregulates TGF-beta1 and CTGF in human hepatic stellate cell line LX-2
    • Guo GH, Tan DM, Zhu PA and Liu F: Hepatitis B virus X protein promotes proliferation and upregulates TGF-beta1 and CTGF in human hepatic stellate cell line, LX-2. Hepatobiliary Pancreat Dis Int 8: 59-64, 2009.
    • (2009) Hepatobiliary Pancreat Dis Int , vol.8 , pp. 59-64
    • Guo, G.H.1    Tan, D.M.2    Zhu, P.A.3    Liu, F.4
  • 25
    • 24944475268 scopus 로고    scopus 로고
    • Isolation and culture of hepatic stellate cells
    • Weiskirchen R and Gressner AM: Isolation and culture of hepatic stellate cells. Methods Mol Med 117: 99-113, 2005.
    • (2005) Methods Mol Med , vol.117 , pp. 99-113
    • Weiskirchen, R.1    Gressner, A.M.2
  • 26
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 27
    • 81355143310 scopus 로고    scopus 로고
    • Cell-context dependent TCF/LEF expression and function: Alternative tales of repression de-repression and activation potentials
    • Mao CD and Byers SW: Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr 21: 207-236, 2011.
    • (2011) Crit Rev Eukaryot Gene Expr , vol.21 , pp. 207-236
    • Mao, C.D.1    Byers, S.W.2
  • 28
    • 84860319933 scopus 로고    scopus 로고
    • MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling
    • Cha YH, Kim NH, Park C, Lee I, Kim HS and Yook JI: MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle 11: 1273-1281, 2012.
    • (2012) Cell Cycle , vol.11 , pp. 1273-1281
    • Cha, Y.H.1    Kim, N.H.2    Park, C.3    Lee, I.4    Kim, H.S.5    Yook, J.I.6
  • 30
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE and Glimcher LH: Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496, 2008.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 31
    • 17744410109 scopus 로고    scopus 로고
    • Insights into binding of fatty acids by fatty acid binding proteins
    • Hanhoff T, Lücke C, Spener F: Insights into binding of fatty acids by fatty acid binding proteins. Mol Cell Biochem 239: 45-54, 2002.
    • (2002) Mol Cell Biochem , vol.239 , pp. 45-54
    • Hanhoff, T.1    Lücke, C.2    Spener, F.3
  • 32
    • 80051613002 scopus 로고    scopus 로고
    • Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
    • Kaller M, Liffers ST, Oeljeklaus S, et al: Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis. Mol Cell Proteomics 10: M111.010462, 2011.
    • (2011) Mol Cell Proteomics , vol.10 , pp. M111010462
    • Kaller, M.1    Liffers, S.T.2    Oeljeklaus, S.3
  • 33
    • 0033855572 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    • Marra F, Efsen E, Romanelli RG et al: Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119: 466-78, 2000.
    • (2000) Gastroenterology , vol.119 , pp. 466-478
    • Marra, F.1    Efsen, E.2    Romanelli, R.G.3
  • 34
    • 33846951514 scopus 로고    scopus 로고
    • Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis
    • Inagaki Y, Okazaki I: Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007.
    • (2007) Gut , vol.56 , pp. 284-292
    • Inagaki, Y.1    Okazaki, I.2
  • 35
    • 84883742665 scopus 로고    scopus 로고
    • MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1
    • Yang S, Li Y, Gao J et al: MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene 32: 4294-4303, 2013.
    • (2013) Oncogene , vol.32 , pp. 4294-4303
    • Yang, S.1    Li, Y.2    Gao, J.3
  • 36
    • 84871221881 scopus 로고    scopus 로고
    • MiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro RE, Ferreira DM, Afonso MB, et al: miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J Hepatol 58: 119-125, 2013.
    • (2013) J Hepatol , vol.58 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.2    Afonso, M.B.3
  • 37
    • 84865249866 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-34a expression in alcoholic liver injury
    • Meng F, Glaser SS, Francis H et al: Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol 181: 804-817, 2012.
    • (2012) Am J Pathol , vol.181 , pp. 804-817
    • Meng, F.1    Glaser, S.S.2    Francis, H.3
  • 38
    • 76249128792 scopus 로고    scopus 로고
    • MiR-221 overexpression contributes to liver tumorigenesis
    • Pineau P, Volinia S, McJunkin K et al: miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci USA 107: 264-269, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.107 , pp. 264-269
    • Pineau, P.1    Volinia, S.2    McJunkin, K.3
  • 39
    • 84864281505 scopus 로고    scopus 로고
    • β -Catenin pathway is required for TGF-beta1 inhibition of PPARγ expression in cultured hepatic stellate cells
    • Qian J, Niu M, Zhai X, Zhou Q and Zhou Y: β-Catenin pathway is required for TGF-beta1 inhibition of PPARγ expression in cultured hepatic stellate cells. Pharmacol Res 66: 219-225, 2012.
    • (2012) Pharmacol Res , vol.66 , pp. 219-225
    • Qian, J.1    Niu, M.2    Zhai, X.3    Zhou, Q.4    Zhou, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.