PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice

Pharmacological Research

Volumn 91, Issue , 2014, Pages 36-46

  Guida, F ^a   Lattanzi, R ^b   Boccella, S ^a   Maftei, S ^b   Romano, R ^a   Marconi, R ^b   Balboni, R ^c   Salvadori, S ^d   Scafuro, M A ^a   De Novellis, V ^a   Negri, L ^b   Maione, S ^a   Luongo, L ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d UNIVERSITY OF FERRARA   (Italy)

Author keywords

Electrophysiology; Glia; Microglia; Neuropathic pain; Prokineticin system; Spinal cord

Indexed keywords

ANALGESIC AGENT; CARRIER PROTEINS AND BINDING PROTEINS; MESSENGER RNA; PC 1; PROKINETICIN 2 PROTEIN; PROTEIN PKR1; PROTEIN PKR2; RECEPTOR; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; NEUROPEPTIDE; PKR1 PROTEIN, MOUSE; PKR2 PROTEIN, MOUSE; PROK2 PROTEIN, MOUSE; TRIAZINE DERIVATIVE;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; GLIA CELL; HYPERALGESIA; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; NERVE INJURY; NERVE STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPINAL CORD; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; HEAT; INJURIES; METABOLISM; NERVE CELL; NEURALGIA; PERIPHERAL NERVE INJURIES; PHYSIOLOGY; SCIATIC NERVE;

ANALGESICS; ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; GASTROINTESTINAL HORMONES; HOT TEMPERATURE; HYPERALGESIA; MALE; MICE; NEURALGIA; NEURONS; NEUROPEPTIDES; PERIPHERAL NERVE INJURIES; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SCIATIC NERVE; SPINAL CORD; TRIAZINES;

EID: 84915818817     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.11.004     Document Type: Article

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