Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature

Pharmacological Research

Volumn 66, Issue 3, 2012, Pages 243-250

  Luongo, Livio ^a,d   Costa, Barbara ^b   D'Agostino, Bruno ^b   Guida, Francesca ^a   Comelli, Francesca ^b   Gatta, Luisa ^a   Matteis, Maria ^b   Sullo, Nikol ^b   De Petrocellis, Luciano ^c,d   De Novellis, Vito ^a,d   Maione, Sabatino ^a,d   Di Marzo, Vincenzo ^c,d  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c CNR   (Italy)

^d Endocannabinoid Research Group   (Italy)

Author keywords

Bronchoconstriction; Capsaicin; Inflammatory pain; Neuropathic pain; Pain; TRPV1; Vanilloid

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CAPSAICIN; CAPSAICIN DERIVATIVE; CARRAGEENAN; FORMALDEHYDE; PALVANIL; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; BODY TEMPERATURE; BRONCHOSPASM; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; EDEMA; EX VIVO STUDY; FEMALE; HYPERALGESIA; HYPOTHERMIA; IN VIVO STUDY; LUNG TOXICITY; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; SCIATIC NERVE INJURY; SYSTEMIC THERAPY;

ANALGESICS; ANIMALS; BODY TEMPERATURE; BRONCHOCONSTRICTION; CAPSAICIN; EDEMA; FEMALE; HYPERALGESIA; HYPOTHERMIA; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEURALGIA; PAIN MEASUREMENT; RESPIRATORY SYSTEM; SCIATIC NERVE; TRPV CATION CHANNELS;

EID: 84864276551     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.05.005     Document Type: Article

References (33)

1. M. Tominaga, M.J. Caterina, A.B. Malmberg, T.A. Rosen, H. Gilbert, and K. Skinner The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 1998 531 543 (Pubitemid 28475505)
2. Giordano C, Cristino L, Luongo L, Siniscalco D, Petrosino S, Piscitelli F, Marabese I, Gatta L, Rossi F, Imperatore R, Palazzo E, de Novellis V, Di Marzo V, Maione S. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cereb Cortex 2011, in press.
3. M.J. Caterina, and D. Julius The vanilloid receptor: a molecular gateway to the pain pathway Annual Review of Neuroscience 24 2001 487 517 (Pubitemid 32695237)
4. K. Starowicz, S. Maione, L. Cristino, E. Palazzo, I. Marabese, and F. Rossi Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways Journal of Neuroscience 27 2007 13739 13749 (Pubitemid 350278253)
5. S. Maione, L. Cristino, A.L. Migliozzi, A.L. Georgiou, K. Starowicz, and T.E. Salt TRPV1 channels control synaptic plasticity in the developing superior colliculus The Journal of Physiology 587 2009 2521 2535
6. S. Maione, K. Starowicz, L. Cristino, F. Guida, E. Palazzo, and L. Luongo Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia Journal of Neurophysiology 10 2009 2411 2422
7. V. de Novellis, D. Vita, L. Gatta, L. Luongo, G. Bellini, and M. De Chiaro The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats Molecular Pain 7 2011 7
8. D.P. Mohapatra, and C. Nau Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway Journal of Biological Chemistry 278 2003 50080 50090 (Pubitemid 37548845)
9. B. Nilius, G. Owsianik, and T. Voets Transient receptor potential channels meet phosphoinositides EMBO Journal 27 2008 2809 2816
10. K. Starowicz, S. Nigam, and V. Di Marzo Biochemistry and pharmacology of endovanilloids Pharmacology & Therapeutics 114 2007 13 33 (Pubitemid 46498161)
11. L. Liu, Y. Lo, I. Chen, and S.A. Simon The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide Journal of Neuroscience 17 1997 4101 4111 (Pubitemid 27220601)
12. D.J. Long, H.R. Devantier, F.X. Brennan, R.W. Bryant, F.R. Salemme, and R.K. Palmer Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay Journal of Pharmacology and Experimental Therapeutics 332 2010 525 530
13. T. Lida, T. Moriyama, K. Kobata, A. Morita, N. Murayama, and S. Hashizume TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate Neuropharmacology 44 2003 958 967 (Pubitemid 36515031)
14. D. Ursu, K. Knopp, R.E. Beattie, B. Liu, and E. Sher Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity European Journal of Pharmacology 641 2010 114 122
15. D. Melck, T. Bisogno, L. De Petrocellis, H. Chuang, D. Julius, and M. Bifulco Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors Biochemical and Biophysical Research Communications 262 1999 275 284 (Pubitemid 29412660)
16. A. Morita, Y. Iwasaki, K. Kobata, T. Iida, T. Higashi, and K. Oda Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1 Life Sciences 79 2006 2303 2310 (Pubitemid 44666065)
17. L. De Petrocellis, F. Guida, A.S. Moriello, M. De Chiaro, F. Piscitelli, and V. de Novellis N-Palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity Pharmacological Research 63 2011 294 299
18. F. Roviezzo, A. Di Lorenzo, M. Bucci, V. Brancaleone, V. Vellecco, and M. De Nardo phingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness American Journal of Respiratory Cell and Molecular Biology 36 2007 757 762 (Pubitemid 46871431)
19. F.V. Abbott, and E.R. Guy Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain Pain 62 1995 303 312
20. F.A. Oliveira, C.L. Costa, M.H. Chaves, F.R. Almeida, I.J. Cavalcante, and A.F. Lima Attenuation of capsaicin-induced acute and visceral nociceptive pain by alpha-and beta-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice Life Sciences 77 2005 2942 2952 (Pubitemid 41390957)
21. A. Calignano, I. Kátona, F. Désarnaud, A. Giuffrida, G. La Rana, and K. Mackie Bidirectional control of airway responsiveness by endogenous cannabinoids Nature 408 2000 96 101
22. B. D'Agostino, D. Orlotti, G. Calò, N. Sullo, M. Russo, and R. Guerrini Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung American Journal of Respiratory Cell and Molecular Biology 42 2010 250 254
23. P. Anand, and K. Bley Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch British Journal of Anaesthesia 107 2011 490 502
24. I. Decosterd, and C.J. Woolf Spared nerve injury: an animal model of persistent peripheral neuropathic pain Pain 87 2000 149 158 (Pubitemid 30621447)
25. E. Palazzo, L. Luongo, V. de Novellis, F. Rossi, I. Marabese, and S. Maione Transient receptor potential vanilloid type 1 and pain development Current Opinion in Pharmacology 12 2012 9 17
26. A.E. Chávez, C.Q. Chiu, and P.E. Castillo TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus Nature Neuroscience 13 2010 1511 1518
27. B.A. Grueter, G. Brasnjo, and R.C. Malenka Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens Nature Neuroscience 13 2010 1519 1525
28. N. Puente, Y. Cui, O. Lassalle, M. Lafourcade, F. Georges, and L. Venance Polymodal activation of the endocannabinoid system in the extended amygdala Nature Neuroscience 14 2011 1542 1547
29. Y.W. Wu, Y.P. Bi, X.X. Kou, W. Xu, L.Q. Ma, and K.W. Wang 17-Beta-estradiol enhanced allodynia of inflammatory temporomandibular joint through upregulation of hippocampal TRPV1 in ovariectomized rats Journal of Neuroscience 30 2010 8710 8719
30. L. Cristino, L. de Petrocellis, G. Pryce, D. Baker, V. Guglielmotti, and V. Di Marzo Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain Neuroscience 139 2006 1405 1415
31. D.J. Cavanaugh, A.T. Chesler, A.C. Jackson, Y.M. Sigal, H. Yamanaka, and R. Grant Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells Journal of Neuroscience 31 2011 5067 5077
32. D.J. Cavanaugh, A.T. Chesler, J.M. Bráz, N.M. Shah, D. Julius, and A.I. Basbaum Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons Journal of Neuroscience 31 2011 10119 10127
33. K. Kobata, K. Saito, H. Tate, A. Nashimoto, H. Okuda, and I. Takemura Long-chain N-vanillyl-acylamides from Capsicum oleoresin Journal of Agricultural and Food Chemistry 58 2010 3627 3631