Flavonols from the Ripe Fruits of Opuntia ficus-indica Var. saboten Protect Neuronal PC-12 Cells against Oxidative Stress

Journal of Food Biochemistry

Volumn 38, Issue 5, 2014, Pages 518-526

  Son, Jung Eun ^a   Lee, Bong Han ^a   Nam, Tae Gyu ^a   Im, Sungbin ^a   Chung, Dae Kyun ^a   Lee, Jung Min ^b   Chun, Ock K ^c   Kim, Dae Ok ^a  

^a Kyung Hee University   (South Korea)

^b Morechem Co Ltd   (South Korea)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CARBOHYDRATES; CELLS; CHLORINE COMPOUNDS; CYTOLOGY; FOOD ADDITIVES; FRUITS; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEURONS; OXIDATIVE STRESS; PHENOLS; VALUE ENGINEERING;

DOSE-DEPENDENT MANNER; INTRACELLULAR LACTATE; INTRACELLULAR OXIDATIVE STRESS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; NEURON-LIKE PC-12 CELLS; PHARMACOLOGICAL ACTIVITY; QUADRUPOLE-TIME OF FLIGHTS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

FLAVONOIDS;

OPUNTIA FICUS-INDICA;

EID: 84915807715     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/jfbc.12088     Document Type: Article

References (41)

1. Ames, B.N., Shigenaga, M.K. and Hagen, T.M. 1993. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U.S.A. 90, 7915-7922.
2. Cho, J.Y., Park, S.-C., Kim, T.-W., Kim, K.-S., Song, J.-C., Kim, S.-K., Lee, H.-M., Sung, H.-J., Park, H.-J., Song, Y.-B. etal. 2006. Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf. J. Pharm. Pharmacol. 58, 113-119.
3. Dai, J. and Mumper, R.J. 2010. Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties. Molecules 15, 7313-7352.
4. Dok-Go, H., Lee, K.H., Kim, H.J., Lee, E.H., Lee, J., Song, Y.S., Lee, Y.-H., Jin, C., Lee, Y.S. and Cho, J. 2003. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 965, 130-136.
5. Echeverry, C., Blasina, F., Arredondo, F., Ferreira, M., Abin-Carriquiry, J.A., Vasquez, L., Aspillaga, A.A., Diez, M.S., Leighton, F. and Dajas, F. 2004. Cytoprotection by neutral fraction of Tannat red wine against oxidative stress-induced cell death. J. Agric. Food Chem. 52, 7395-7399.
6. Fernández-López, J.A. and Almela, L. 2001. Application of high-performance liquid chromatography to the characterization of the betalain pigments in prickly pear fruits. J. Chromatogr. A 913, 415-420.
7. Floegel, A., Kim, D.-O., Chung, S.-J., Koo, S.I. and Chun, O.K. 2011. Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. J. Food Compost. Anal. 24, 1043-1048.
8. Forni, E., Polesello, A., Montefiori, D. and Maestrelli, A. 1992. High-performance liquid chromatographic analysis of the pigments of blood-red prickly pear (Opuntia ficus indica). J. Chromatogr. 593, 177-183.
9. Galati, E.M., Monforte, M.T., Tripodo, M.M., D'Aquino, A. and Mondello, M.R. 2001. Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): Ultrastructural study. J. Ethnopharmacol. 76, 1-9.
10. Han, Y.N., Choo, Y., Lee, Y.-C., Moon, Y.-I., Kim, S.-D. and Choi, J.-W. 2001. Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten. Arch. Pharm. Res. 24, 51-54.
11. Harborne, J.B. and Williams, C.A. 2000. Advances in flavonoid research since 1992. Phytochemistry 55, 481-504.
12. Heber, D. 2004. Vegetables, fruits and phytoestrogens in the prevention of diseases. J. Postgrad. Med. 50, 145-149.
13. Heo, H.-J., Cho, H.-Y., Hong, B., Kim, H.-K., Kim, E.-K., Kim, B.-G. and Shin, D.-H. 2001. Protective effect of 4′, 5-dihydroxy-3′, 6, 7-trimethoxyflavone from Artemisia asiatica against Aβ-induced oxidative stress in PC12 cells. Amyloid 8, 194-201.
14. Ishige, K., Schubert, D. and Sagara, Y. 2001. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic. Biol. Med. 30, 433-446.
15. Jia, Z., Tang, M. and Wu, J. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64, 555-559.
16. Kaur, M., Kaur, A. and Sharma, R. 2012. Pharmacological actions of Opuntia ficus indica: A review. J. Appl. Pharm. Sci. 2, 15-18.
17. Kim, D.-O., Lee, K.W., Lee, H.J. and Lee, C.Y. 2002. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J. Agric. Food Chem. 50, 3713-3717.
18. Koppula, S., Kumar, H., More, S.V., Kim, B.W., Kim, I.S. and Choi, D.K. 2012. Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. Int. J. Mol. Sci. 13, 10608-10629.
19. Kuti, J.O. 2004. Antioxidant compounds from four Opuntia cactus pear fruit varieties. Food Chem. 85, 527-533.
20. Lee, E.B., Hyun, J.E., Li, D.W. and Moon, Y.I. 2002. Effects of Opuntia ficus-indica var, saboten stem on gastric damages in rats. Arch. Pharm. Res. 25, 67-70.
21. Lee, E.H., Kim, H.J., Song, Y.S., Jin, C., Lee, K.-T., Cho, J. and Lee, Y.S. 2003. Constituents of the stems and fruits of Opuntia ficus-indica var. saboten. Arch. Pharm. Res. 26, 1018-1023.
22. Lee, N.H., Yoon, J.-S., Lee, B.H., Choi, B.W. and Park, K.H. 2000. Screening of the radical scavenging effects, tyrosinase inhibition and anti-allergic activities using Opuntia ficus-indica. Korean J. Pharmacogn. 31, 412-415.
23. Lee, S.G., Lee, H., Nam, T.G., Eom, S.H., Heo, H.J., Lee, C.Y. and Kim, D.-O. 2011. Neuroprotective effect of caffeoylquinic acids from Artemisia princeps Pampanini against oxidative stress-induced toxicity in PC-12 cells. J. Food Sci. 76, C250-C256.
24. Lim, D., Kim, W., Lee, M.-G., Heo, H.J., Chun, O.K. and Kim, D.-O. 2012. Evidence for protective effects of coffees on oxidative stress-induced apoptosis through antioxidant capacity of phenolics. Food Sci. Biotechnol. 21, 1735-1744.
25. Liu, R., Wang, X., Zhao, Y., Wang, Z. and Du, L. 2006. The uptake behaviors of kaempferol and quercetin through rat primary cultured cortical neurons. Biomed. Chromatogr. 20, 1178-1184.
26. Pandey, K.B. and Rizvi, S.I. 2009. Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev. 2, 270-278.
27. Park, E.-H., Kahng, J.-H. and Paek, E.-A. 1998. Studies on the pharmacological actions of cactus: Identification of its anti-inflammatory effect. Arch. Pharm. Res. 21, 30-34.
28. Park, E.-H., Kahng, J.-H., Lee, S.H. and Shin, K.-H. 2001. An anti-inflammatory principle from cactus. Fitoterapia 72, 288-290.
29. Prasad, M.R., Lovell, M.A., Yatin, M., Dhillon, H. and Markesbery, W.R. 1998. Regional membrane phospholipid alterations in Alzheimer's disease. Neurochem. Res. 23, 81-88.
30. Riboli, E. and Norat, T. 2003. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr. 78, 559S-569S.
31. Sies, H. and Stahl, W. 1995. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am. J. Clin. Nutr. 62, 1315S-1321S.
32. Singleton, V.L. and Rossi, J.A., Jr. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16, 144-158.
33. Soto-Vaca, A., Gutierrez, A., Losso, J.N., Xu, Z. and Finley, J.W. 2012. Evolution of phenolic compounds from color and flavor problems to health benefits. J. Agric. Food Chem. 60, 6658-6677.
34. Spencer, J.P.E. 2009. Flavonoids and brain health: Multiple effects underpinned by common mechanisms. Genes Nutr. 4, 243-250.
35. Sriseadka, T., Wongpornchai, S. and Rayanakorn, M. 2012. Quantification of flavonoids in black rice by liquid chromatography-negative electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 60, 11723-11732.
36. Strack, D., Vogt, T. and Schliemann, W. 2003. Recent advances in betalain research. Phytochemistry 62, 247-269.
37. Trejo-González, A., Gabriel-Ortiz, G., Puebla-PéRez, A.M., HuíZar-Contreras, M.D., MunguíA-Mazariegos, M.D.R., MejíA-Arreguín, S. and Calva, E. 1996. A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. J. Ethnopharmacol. 55, 27-33.
38. Uttara, B., Singh, A.V., Zamboni, P. and Mahajan, R.T. 2009. Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 7, 65-74.
39. Wolfe, K.L. and Liu, R.H. 2007. Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements. J. Agric. Food Chem. 55, 8896-8907.
40. Yang, M., Koo, S.I., Song, W.O. and Chun, O.K. 2011. Food matrix affecting anthocyanin bioavailability: Review. Curr. Med. Chem. 18, 291-300.
41. Yoo, K.M., Kim, D.-O. and Lee, C.Y. 2007. Evaluation of different methods of antioxidant measurement. Food Sci. Biotechnol. 16, 177-182.