BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16520-16525

  Leibowitz, Brian ^a,b   Qiu, Wei ^a,b   Buchanan, Monica E ^a,c   Zou, Fangdong ^a,c,d   Vernon, Philip ^a   Moyer, Mary P ^e   Yin, Xiao Ming ^b,f   Schoen, Robert E ^a,g   Yu, Jian ^a,b   Zhang, Lin ^a,c  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b Pathology ^*  (China)

^c Pharmacology and Chemical Biology   (China)

^d SICHUAN UNIVERSITY   (China)

^e INCELL Corporation ^*  (United States)

^f INDIANA UNIVERSITY   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; APC PROTEIN; CASPASE 8; DEATH RECEPTOR; INDOMETACIN; MYC PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BID; SULINDAC; 4-(5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)BENZENESULFONAMIDE; APOPTOSIS REGULATORY PROTEIN; BID PROTEIN, HUMAN; BID PROTEIN, MOUSE; CASPASE; PYRAZOLE DERIVATIVE; SMALL INTERFERING RNA; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CANCER MODEL; CANCER PREVENTION; CANCER STEM CELL; CARCINOGENESIS; CELL KILLING; CLINICAL ARTICLE; COLON ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; ADENOMATOUS POLYPOSIS COLI; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; C57BL MOUSE; COLON; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; ONCOGENE MYC; PATHOLOGY; PHYSIOLOGY; SMALL INTESTINE; STEM CELL; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

MUS; PYRONIA TITHONUS;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE, TUMOR; COLON; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; GENES, MYC; HUMANS; INDOMETHACIN; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; ORGAN SPECIFICITY; PYRAZOLES; RECEPTORS, DEATH DOMAIN; RNA, SMALL INTERFERING; STEM CELLS; SULFONAMIDES; SULINDAC;

EID: 84915784916     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415178111     Document Type: Article

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