Effect of kuwanon G isolated from the root bark of Morus alba on ovalbumin-induced allergic response in a mouse model of asthma

Phytotherapy Research

Volumn 28, Issue 11, 2014, Pages 1713-1719

  Jung, Hyo Won ^a   Kang, Seok Yong ^b   Kang, Jong Seong ^c   Kim, A Ryun ^d   Woo, Eun Rhan ^d   Park, Yong Ki ^a,b  

^a Dongguk University   (South Korea)

^b Dongguk University   (South Korea)

^c Chungnam National University   (South Korea)

^d Chosun University   (South Korea)

Author keywords

Allergic asthma; Immunoglobulin E; Kuwanon G; Lung inflammation; Mori Cortex Radicis; Morus alba; Ovalbumin; Th2 cytokines

Indexed keywords

ANTIASTHMATIC AGENT; COLLAGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; KETOTIFEN; KUWANON G; OVALBUMIN; UNCLASSIFIED DRUG; FLAVONOID;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; BRONCHIOLE; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; EPITHELIUM; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; INFLAMMATORY CELL; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MORUS ALBA; MOUSE; MUCUS; NONHUMAN; PLANT ROOT; PROTEIN BLOOD LEVEL; SENSITIZATION; SEROLOGY; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HYPERSENSITIVITY; IMMUNOLOGY; LUNG; MORUS; PATHOLOGY;

MORUS ALBA;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FLAVONOIDS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; LUNG; MALE; MICE, INBRED BALB C; MORUS; OVALBUMIN; PLANT BARK; PLANT ROOTS;

EID: 84915751474     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5191     Document Type: Article

References (37)

1. Bielory L. 2004. Complementary and alternative interventions in asthma, allergy and immunology. Ann Allergy AsthmaImmunol 93: S45-S54.
2. Chen F, Nakashima N, Kimura I, Kimura M. 1995. Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocininduced diabetic mice. Yakugaku Zasshi 115: 476-482.
3. Chen M, Lv Z, Jiang S. 2011. The effects of triptolide on airway remodelling and transforming growth factor-?1/Smad signalling pathway in ovalbumin-sensitized mice. Immunology 132: 376-384.
4. Chung Y, Dumont RC. 2011. Complementary and alternative therapies: use in pediatric pulmonary medicine. Pediatr Pulmonol 46: 530-544.
5. Corren J. 2011. Anti-interleukin-5 antibody therapy in asthma and allergies. Curr Opin Allergy Clin Immunol 11: 565-570.
6. Corren J. 2013. Role of interleukin-13 in asthma. Curr Allergy Asthma Rep 13: 415-420.
7. Deo SS, Mistry KJ, Kakade AM, Niphadkar PV. 2010. Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India 27: 66-71.
8. Dietert RR. 2011. Maternal and childhood asthma: risk factors, interactions, and ramifications. Reprod Toxicol 32: 198-204.
9. Devillier P. 2001. Anti-asthma drugs. Rev Prat 51: 523-531.
10. Domingo C, Moreno A, Mirapeix R. 2011. Rationale for the use of immunomodulatory therapies in the Global Initiative for Asthma (GINA) step V asthma other than oral glucocorticosteroids. Intern Med J 41: 525-536.
11. Du J, He ZD, Jiang RW, et al. 2003. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 62: 1235-1238.
12. El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. 2006. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterolfed rats. Life Sci 78: 2724-2733.
13. Epstein MM. 2006. Are mouse models of allergic asthma useful for testing novel therapeutics? Exp Toxicol Pathol 57: 41-44.
14. Greenfeder S, Umland SP, Cuss FM, et al. 2001. Review Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease. Respir Res 2: 71-79.
15. Ham A, Lee HJ, Hong SS, et al. 2012. Moracenin D from Mori Cortex radicis protects SH-SY5Y cells against dopamine-induced cell death by regulating nurr1 and ?-synuclein expression. Phytother Res 26: 620-624.
16. Hamelmann E, Tadeda K, Oshiba A, Gelfand EW. 1999. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness-a murine model. Allergy 54: 297-305.
17. Kim HM, Han SB, Lee KH, et al. 2000. Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis. Arch Pharm Res 23: 240-242.
18. Kim HJ, Lee HJ, Jeong SJ, et al. 2011. Cortex Mori Radicis extract exerts antiasthmatic effects via enhancement of CD4(+) CD25(+)Foxp3(+) regulatory T cells and inhibition of Th2 cytokines in a mouse asthma model. J Ethnopharmacol 138: 40-46.
19. Kudo M, Ishigatsubo Y, Aoki I. 2013. Pathology of asthma. Front Microbiol 4: 263.
20. Kumar RK, Herbert C, Foster PS. 2008. The classical ovalbumin challenge model of asthma in mice. Curr Drug Targets 9: 485-484.
21. Lee HJ, Lyu da H, Koo U, et al. 2011. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SHSY5Y cells. Arch Pharm Res 34: 1373-1380.
22. Lee HJ, Lyu da H, Koo U, et al. 2012. Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. Arch Pharm Res 35: 163-170.
23. Lee MS, Park WS, Kim YH, et al. 2013. Antidepressant-like effects of Cortex Mori Radicis extract via bidirectional phosphorylation of glucocorticoid receptors in the hippocampus. Behav Brain Res 236: 56-61.
24. Li XM, Brown L. 2009. Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol 123: 297-306.
25. Martinez FD, Vercelli D. 2013. Asthma. Lancet 382: 1360-1372.
26. Mihara S, Hara M, Nakamura M, et al. 1995. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun 213: 594-599.
27. Nam SY, Yi HK, Lee JC, et al. 2002. Cortex Mori extract induces cancer cell apoptosis through inhibition of microtubule assembly. Arch Pharm Res 25: 191-196.
28. Nomura T, Fukai T, Narita T. 1980. Hypotensive constituent, kuwanon H, a new flavone derivative form the root bark of the cultivated mulberry thee (Morus alba L.) Heterocycles 14: 1943-1951.
29. Oshima Y, Konno C, Hikino H, Matsushita K. 1980. Structure of moracenin B, a hypotensive principle of Morus root barks. Tetrahedron Lett 21: 3381-3384.
30. Park KM, You JS, Lee HY, et al. 2003. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol 84: 181-185.
31. Shepherd JM, Duddleston DN, Hicks GS, et al. 2002. Asthma: a brief overview. Am J Med Sci 324: 174-179.
32. Shikotra A, Siddiqui S. 2013. The role of tissue eosinophils in asthmatic airway remodelling. Clin Exp Allergy 43: 1302-1306.
33. Shum BO, Rolph MS, Sewell WA. 2008. Mechanisms in allergic airway inflammation-lessons from studies in the mouse. Expert Rev Mol Med 10: e15.
34. Wang R, Lu XC, Wang YW. 2002. Antiinflammatory activity of the extracts of Ramulus mori. Journal of Wuhan Botanical Research 20: 467-446.
35. Wills-Karp M. 2004. Interleukin-13 in asthma pathogenesis. Immunol Rev 202: 175-190.
36. Yoshihara S, Ono M, Yamada Y, et al. 2009. Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study. Pediatr Allergy Immunol 20: 486-492.
37. Zhang M, Chen M, Zhang HQ, et al. 2009. In vivo hypoglycemic effects of phenolics from the root bark of Morus alba. Fitoterapia 80: 475-477.