Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: A pilot study

Pediatric Allergy and Immunology

Volumn 20, Issue 5, 2009, Pages 486-492

  Yoshihara, Shigemi ^a   Ono, Mika ^a   Yamada, Yumi ^a   Fukuda, Hironobu ^a   Abe, Toshio ^a   Arisaka, Osamu ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Early intervention; Eosinophil; Pediatric asthma; Suplatast tosilate; Th1 Th2 ratio

Indexed keywords

IMMUNOGLOBULIN E; KETOTIFEN FUMARATE; SUPLATAST TOSYLATE;

ABSENCE OF SIDE EFFECTS; ALLERGIC ASTHMA; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DRUG FORMULATION; EOSINOPHIL COUNT; FEMALE; FOOD ALLERGY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PILOT STUDY; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; SEDATION; SIDE EFFECT; TH1 CELL; TH2 CELL; TREATMENT OUTCOME; TREATMENT RESPONSE; WHEEZING;

ALLERGENS; ANIMALS; ANTI-ALLERGIC AGENTS; ARYLSULFONATES; ASTHMA; CHEMOPREVENTION; DERMATITIS, ATOPIC; EGG WHITE; FEMALE; FOOD HYPERSENSITIVITY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INCIDENCE; INFANT; KETOTIFEN; MALE; MILK; PILOT PROJECTS; RESPIRATORY SOUNDS; SULFONIUM COMPOUNDS; TH1 CELLS; TH2 CELLS; TIME FACTORS; TREATMENT OUTCOME;

EID: 68349083553     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2008.00807.x     Document Type: Article

References (34)

1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. N Engl J Med 1995 : 332 : 133 8.
2. Sly RM. Changing prevalence of allergic rhinitis and asthma. Ann Allergy Asthma Immunol 1999 : 82 : 233 48.
3. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study.1980 to present. J Allergy Clin Immunol 2003 : 111 : 661 75.
4. Kulig M, Bergmann R, Tacke U, Wahn U, Guggenmoos-Holzmann I. Long-lasting sensitization to food during the first two years precedes allergic airway disease. The MAS Study Group, Germany. Pediatr Allergy Immunol 1998 : 9 : 61 7.
5. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med 1990 : 323 : 502 7.
6. Rhodes HL, Sporik R, Thomas P, Holgate ST, Cogswell JJ. Early life risk factors for adult asthma: a birth cohort study of subjects at risk. J Allergy Clin Immunol 2001 : 108 : 720 5.
7. Roberts G, Patel N, Levi-Schaffer F, Habibi P, Lack G. Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study. J Allergy Clin Immunol 2003 : 112 : 168 74.
8. Bergmann RL, Edenharter G, Bergmann KE, et al. Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy 1998 : 28 : 965 70.
9. Iikura Y, Naspitz CK, Mikawa H, et al. Prevention of asthma by ketotifen in infants with atopic dermatitis. Ann Allergy 1992 : 68 : 233 6.
10. Warner JO, ETAC Study Group. Early treatment of the atopic child. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up. J Allergy Clin Immunol 2001 : 108 : 929 37
11. Yanagihara Y, Kiniwa M, Ikizawa K, Shida T, Matsuura N, Koda A. Suppression of IgE production by IPD-1151T (suplatast tosilate), a new dimethylsulfonium agent: (2) regulation of human IgE response. Jpn J Pharmacol 1993 : 61 : 31 9.
12. Iijima H, Tamura G, Hsiue TR, Liu Y, Taniguchi H, Shirato K. Suplatast tosilate inhibits late response and airway inflammation in sensitized guinea pigs. Am J Respir Crit Care Med 1999 : 160 : 331 5.
13. Zhao GD, Yokoyama A, Kohno N, Sakai K, Hamada H, Hiwada K. Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness. Int Arch Allergy Immunol 2000 : 121 : 116 21.
14. Shim JJ, Dabbagh K, Takeyama K, et al. Suplatast tosilate inhibits goblet-cell metaplasia of airway epithelium in sensitized mice. J Allergy Clin Immunol 2000 : 105 : 739 45.
15. Ueno K, Samson K, Chen H, et al. Food allergy and liver/intestines. Effect of suplatast tosilate and chinese traditional medicines. Allergy Clin Immunol Int 2004 : 1 : 310 6.
16. Tamaoki J, Takeyama K, Aoshiba K, Nakata J, Nishimura K, Nagai A. A Th2 cytokine inhibitor for airway inflammation in mild asthma. J Allergy Clin Immunol 2003 : 111 : 197 8.
17. Sano Y, Suzuki N, Yamada H, et al. Effects of suplatast tosilate on allergic eosinophilic airway inflammation in patients with mild asthma. J Allergy Clin Immunol 2003 : 111 : 958 66.
18. Tamaoki J, Kondo M, Sakai N, et al. Effect of suplatast tosilate, a Th2 cytokine inhibitor, on steroid-dependent asthma: a double-blind randomized study. Lancet 2000 : 356 : 273 8.
19. Hoshino M, Fujita Y, Saji J, Inoue T, Nakagawa T, Miyazawa T. Effect of suplatast tosilate on goblet cell metaplasia in patient with asthma. Allergy 2005 : 60 : 1394 400.
20. Warner JA, Jones CA, Jones AC, Warner JO. Prenatal origins of allergic disease. J Allergy Clin Immunol 2000 : 2 (Pt2 S493 8.
21. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999 : 353 : 196 200.
22. Yamamoto S, Kohmo Y. Guidelines For The Management of Atopic Dermatitis. Japan : Kyowakikaku, 2006.
23. Kohsaka T, Miyazaki T, Noma Y, et al. Examination for detection of intracellular cytokines by flow cytometry. J Med Pharm Sci 1997 : 38 : 875 82.
24. Rhodes HL, Thomas P, Sporik R, Holgate ST, Cogswell JJ. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. Am J Respir Crit Care Med 2002 : 165 : 176 80.
25. Ohshima Y, Yamada A, Hiraoka M, et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: result of a 4-year followup study. Ann Allergy Asthma Immunol 2002 : 89 : 265 70.
26. Washio Y, Ohashi Y, Tanaka A, et al. Suplatast tosilate affects the initial increase in specific IgE and Interleukin-4 during immunotherapy for perennial allergic rhinitis. Acta Otolaryngol 1998 : 538 : 126 32.
27. Laan MP, Baert MR, Bijl AM, et al. Markers for early sensitization and inflammation in relation to clinical manifestations of atopic disease up to 2 years of age in 133 high-risk children. Clin Exp Allergy 2000 : 30 : 944 53.
28. Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized dermatophagoides pteronyssinus extract. VI specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997 : 99 : 450 3.
29. Sigrus N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytical virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000 : 161 : 1501 7.
30. Marguet C, Dean TP, Basuyau JP, Warner JO. Eosinophil cationic protein and interleukin-8 levels in bronchial lavage fluid from children with asthma and infantile wheeze. Pediatr Allergy Immunol 2001 : 12 : 27 33.
31. Pohunek P, Warner JO, Turzikova J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol 2005 : 16 : 43 51.
32. Castro- Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000 : 162 : 1403 6.
33. Guilbert TW, Morgan WJ, Zeiger RS, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004 : 114 : 1282 7.
34. Sano Y, Yamada H. Progress in suplatast tosilate reserch. Clin Exp Allergy 2007 : 37 : 970 2.