Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns

Journal of Neuroscience

Volumn 34, Issue 49, 2014, Pages 16467-16481

  Yang, Dianer ^a,b   Sun, Yu Yo ^a,b   Bhaumik, Siddhartha Kumar ^a   Li, Yikun ^a,b   Baumann, Jessica M ^a,b   Lin, Xiaoyi ^a,b   Zhang, Yujin ^c   Lin, Shang Hsuan ^d   Dunn, R Scott ^e   Liu, Chia Yang ^c   Shie, Feng Shiun ^f   Lee, Yi Hsuan ^d   Wills Karp, Marsha ^g   Chougnet, Claire A ^e   Kallapur, Suhas G ^e   Lewkowich, Ian P ^e   Lindquist, Diana M ^e   Murali Krishna, Kaja ^a,h   Kuan, Chia Yi ^a,b  

^a Children’s Healthcare of Atlanta ^*  (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^g JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^h INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

Adaptive immunity; Chorioamnionitis; Choroid plexus; Fingolimod; FTY720; Th17

Indexed keywords

FINGOLIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 23 RECEPTOR; LIPOPOLYSACCHARIDE; CYTOKINE; IL23R PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN RECEPTOR; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CELL MIGRATION; CHORIOAMNIONITIS; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN TISSUE; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; INFANT; LYMPHOCYTE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANALOGS AND DERIVATIVES; ANIMAL; ATROPHY; BLOOD BRAIN BARRIER; BRAIN; CELL MOTION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; INFLAMMATION; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PREGNANCY; T LYMPHOCYTE; WHITE MATTER;

ANIMALS; ANIMALS, NEWBORN; ATROPHY; BLOOD-BRAIN BARRIER; BRAIN; CELL MOVEMENT; CHORIOAMNIONITIS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FINGOLIMOD HYDROCHLORIDE; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; IMMUNOSUPPRESSIVE AGENTS; INFANT, NEWBORN; INFLAMMATION; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; NF-KAPPA B; PREGNANCY; PROPYLENE GLYCOLS; RATS; RECEPTORS, INTERLEUKIN; SPHINGOSINE; T-LYMPHOCYTES; WHITE MATTER;

EID: 84914706376     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2582-14.2014     Document Type: Article

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