VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2 -dependent ca2+signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages 4706-4715

  Faviaa, Annarita ^a   Desiderib, Marianna ^b   Gambaraa, Guido ^a   D'Alessioa, Alessio ^a,c   Ruas, Margarida ^d   Esposito, Bianca ^a   Bufalo, Donatella Del ^b   Parrington, John ^d   Ziparoa, Elio ^a   Palombia, Fioretta ^a   Galioned, Antony ^d   Filippini, Antonio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antiangiogenic strategies |; Calcium signaling |; Endothelial cells |; Naadp receptors |; TPC2

Indexed keywords

CALCIUM ION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN KINASE B; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; 1-(3-((4-(2-FLUOROPHENYL)PIPERAZIN-1-YL)METHYL)-4-METHOXYPHENYL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO(3,4-B)INDOLE-3-CARBOXYLIC ACID; CALCIUM CHANNEL; CARBOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PIPERAZINE DERIVATIVE; TPCN1 PROTEIN, HUMAN; TPCN1 PROTEIN, MOUSE; TPCN2 PROTEIN, HUMAN; TPCN2 PROTEIN, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN; VEGFR2 PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MIGRATION; CELL PROLIFERATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CARBOLINES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, KNOCKOUT; NADP; NEOVASCULARIZATION, PHYSIOLOGIC; PIPERAZINES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84914696686     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406029111     Document Type: Article

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