Time efficient way to calculate oxygen transfer areas and power input in cylindrical disposable shaken bioreactors

Biotechnology Progress

Volumn 30, Issue 6, 2014, Pages 1441-1456

  Klöckner, Wolf ^a   Lattermann, Clemens ^a   Pursche, Franz ^a   Büchs, Jochen ^a   Werner, Sören ^b   Eibl, Dieter ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

Author keywords

Liquid distribution; Orbitally shaken bioreactors; Oxygen transfer; Single use

Indexed keywords

BIOCONVERSION; BIOREACTORS; COMPUTATIONAL FLUID DYNAMICS; CULTIVATION; LIQUIDS; MAMMALS; OXYGEN;

CULTIVATION CONDITIONS; DIFFERENT OPERATING CONDITIONS; LIQUID DISTRIBUTION; NEW MATHEMATICAL MODEL; OXYGEN TRANSFER; SHAKEN BIOREACTORS; SINGLE USE; VOLUMETRIC OXYGEN TRANSFER;

BIOLOGICAL WATER TREATMENT;

OXYGEN;

BIOREACTOR; CELL CULTURE; CULTURE TECHNIQUE; FLOW KINETICS; METABOLISM; OXYGEN CONSUMPTION; PHYSIOLOGY; PROCEDURES; THEORETICAL MODEL;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; MODELS, THEORETICAL; OXYGEN; OXYGEN CONSUMPTION; RHEOLOGY;

EID: 84914670161     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1977     Document Type: Article

References (32)

1. Anderlei T, Cesana C, Bürki C, De Jesus M, Kühner M, Wurm F M, Lohser R. Shaken bioreactors provide culture alternative. Genet Eng Biotechnol News. 2009;29:44.
2. Werner S, Eibl R, Lettenbauer C, Röll M, Eibl D, De Jesus M, Zhang X, Stettler M, Tissot S, Bürki C, Broccard G, Kühner M, Tanner R, Baldi L, Hacker D, Wurm F M . Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers-A swiss contribution. CHIMIA. 2010;64:819-823.
3. Klöckner W, Büchs J. Advances in shaking technologies. Trends Biotechnol. 2012;30:307-314.
4. Büchs J, Zoels B. Evaluation of maximum to specific power consumption ratio in shaking bioreactors. J Chem Eng Jpn. 2001;34:647-653.
5. Büchs J, Maier U, Lotter S, Peter C P. Calculating liquid distribution in shake flasks on rotary shakers at waterlike viscosities. Biochem Eng J. 2007;34:200-208.
6. Liu C, Hong L. Development of a shaking bioreactor system for animal cell cultures. Biochem Eng J. 2001;7:121-125.
7. Muller N, Girard P, Hacker D L, Jordan M, Wurm F M. Orbital shaker technology for the cultivation of mammalian cells in suspension. Biotechnol Bioeng. 2005;89:400-406.
8. Stettler M, Zhang M, Hacker D L, De Jesus M, Wurm F M. Novel orbital shake bioreactors for transient production of CHO derived IgGs. Biotechnol Prog. 2007;23:1340-1346.
9. Zhang X, Stettler M, Sanctis D, Perrone M, Parolini N, Discacciati M, De Jesus M, Hacker D, Quarteroni A, Wurm F M. Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter-scale to the 1, 000-liter scale. Adv Biochem Eng Biotechnol. 2009a:1-21.
10. Büchs J. Introduction to advantages and problems of shaken cultures. Biochem Eng J. 2001;7:91-98.
11. Kato Y, Peter C P, Akgün A, Büchs J. Power consumption and heat transfer resistance in large rotary shaking vessels. Biochem Eng J. 2004;21:83-91.
12. Raval K, Kato Y, Büchs J. Comparison of torque method and temperature method for determination of power consumption in disposable shaken bioreactors. Biochem Eng J. 2007;34:224-227.
13. Raval K Büchs J. Extended method to evaluate power consumption in large disposable shaking bioreactors. J Chem Eng Jpn. 2008;41:1075-1082.
14. Klöckner W, Tissot S, Wurm F M, Büchs J. Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors. Biochem Eng J. 2012;65:63-69.
15. Zhang X, Stettler M, Reif O, Kocourek A, De Jesus M, Hacker D L, Wurm F M. Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 l by surface aeration with air. New Biotechnol. 2008;25:68-75.
16. Zhang X, Burki C-A, Stettler M, De Sanctis D, Perrone M, Discacciati M, Parolini N, DeJesus M, Hacker D L, Quarteroni A, Wurm F M. Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000 L. Biochem Eng J. 2009b;45:41-47.
17. Tissot S, Michel P O, Hacker D L, Baldi L, De Jesus M, Wurm F M. k(L)a as a predictor for successful probe-independent mammalian cell bioprocesses in orbitally shaken bioreactors. New Biotech. 2012;29:387-394.
18. Klöckner W, Gacem R, Anderlei T, Raven N, Schillberg S, Lattermann C, Büchs J. Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale. J Biol Eng. 2013;7:28.
19. Tissot S, Farhat M, Hacker D L, Anderlei T, Kühner M, Comninellis C, Wurm F. Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors. Biochem Eng J. 2010;52:181-186.
20. Li C, Xia J Y, Chu J, Wang Y H, Zhuang Y P, Zhang S L. CFD analysis of the turbulent flow in baffled shake flasks. Biochem Eng J. 2013;70:140-150.
21. Discacciati M, Hacker D, Quarteroni A, Quinodoz S, Tissot S, Wurm F M. Numerical simulation of orbitally shaken viscous fluids with free surface. Int J Numer Meth Fluids. 2013;71:294-315.
22. Linek V, Vacek V. Chemical engineering use of catalyzed sulfite oxidation kinetics for the determination of mass transfer characteristics of gas-liquid contactors. Chem Eng Sci. 1981;36:1747-1768.
23. Reith T, Beek W. The oxidation of aqueous sodium sulphite solutions. Chem Eng Sci. 1973;28:1331-1339.
24. Anderlei T, Zang W, Papaspyrou M, Büchs J. Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem Eng J. 2004;17:187-194.
25. Hermann R, Lehmann M, Büchs J. Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnol Bioeng. 2003;81:178-186.
26. Kensy F, Zimmermann H, Knabben I, Anderlei T, Trauthwein H, Dingerdissen U, Büchs J. Oxygen transfer phenomena in 48-well microtiter plates: Determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth. Biotechnol Bioeng. 2005;89:698-708.
27. Linek V, Kordac M, Moucha T. Evaluation of the optical sulfite oxidation method for the determination of the interfacial mass transfer area in small-scale bioreactors. Biochem Eng J. 2006;27:264-268.
28. Büchs J, Maier U, Milbradt C, Zoels B. Power consumption in shaking flasks on rotary shaking machines. I. Power consumption measurement in unbaffled flasks at low liquid viscosity. Biotechnol Bioeng. 2000;68:589-593.
29. Maier U, Büchs J. Characterisation of the gas-liquid mass transfer in shaking bioreactors. Biochem Eng J. 2001;7:99-106.
30. Theodorsen T, Regier A. Experiments on drag of revolving disks, cylinders, and streamline rods at high speeds. In NACA wartime reports Langley Memorial Aeronautical Laboratory, Langley Field, VA, 1944:1-52.
31. Hondzo M, Wüest A. Do microscopic organisms feel turbulent flows? Environ Sci Technol. 2009;43:764-768.
32. Maier U, Losen M, Büchs J. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochem Eng J. 2004;17:155-167.