Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness, and an important role for upper motor neurons

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 15, Issue 7-8, 2014, Pages 481-487

  Devine, Matthew S ^a,b   Kiernan, Matthew C ^c,d   Heggie, Susan ^a   McCombe, Pamela A ^a,b   Henderson, Robert D ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Amyotrophic lateral sclerosis; Anterior horn cell disease; Handedness; Limb dominance; Motor neuron disease

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARM; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HYPERREFLEXIA; LIMB; LIMB DOMINANCE; LIMB WEAKNESS; LOWER MOTOR NEURON; MAJOR CLINICAL STUDY; MALE; MOTONEURON; MOTOR PERFORMANCE; QUESTIONNAIRE; SCORING SYSTEM; UPPER MOTOR NEURON; VERY ELDERLY; ANALYSIS OF VARIANCE; COHORT ANALYSIS; COMPLICATION; DISEASE COURSE; LEG; MIDDLE AGED; MOVEMENT DISORDERS; MUSCLE WEAKNESS; PATHOLOGY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; MOVEMENT DISORDERS; MUSCLE WEAKNESS; SEVERITY OF ILLNESS INDEX; SURVEYS AND QUESTIONNAIRES; UPPER EXTREMITY;

EID: 84914666756     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2014.906617     Document Type: Article

References (29)

1. Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, et al. Amyotrophic lateral sclerosis. Lancet. 2011;377:942-55.
2. Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, et al. Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol. 2013;12:310-22.
3. Ravits J, Paul P, Jorg C. Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology. 2007;68:1571-5.
4. Körner S, Kollewe K, Fahlbusch M, Zapf A, Dengler R, Krampfl K, et al. Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis. Muscle Nerve. 2011;43:636-42.
5. Gargiulo-Monachelli GM, Janota F, Bettini M, Shoesmith CL, Strong MJ, Sica RE. Regional spread pattern predicts survival in patients with sporadic amyotrophic lateral sclerosis. Eur J Neurol. 2012;19:834-41.
6. Turner MR, Wicks P, Brownstein CA, Massagli MP, Toronjo M, Talbot K, et al. Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2011;82:853-4.
7. Haverkamp LJ, Appel V, Appel SH. Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. Brain. 1995;118:707-19.
8. Devine MS, Woodhouse H, McCombe PA, Henderson RD. The relationship between limb dominance, disease lateralization and spread of weakness in amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:150-1.
9. Williams SM. Edinburgh Handedness Inventory (revised). 2010 (online). Available at: http://homepage.ntlworld.com/steve.williams7/A%20major%20revision%20of%20the%20Edinburgh%20Handedness%20Inventory.pdf. Accessed May 27, 2012.
10. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97-113.
11. Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:293-9.
12. Vucic S, Kiernan MC. Abnormalities in cortical and peripheral excitability in flail arm variant amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78:849-52.
13. Wijesekera LC, Mathers S, Talman P, Galtrey C, Parkinson MH, Ganesalingam J, et al. Natural history and clinical features of the flail arm and flail leg ALS variants. Neurology. 2009;72;1087-94.
14. Ravits JM, La Spada AR. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology. 2009;73:805-11.
15. Ravits J, Laurie P, Fan Y, Moore DH. Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss post mortem. Neurology. 2007;68:1576-82.
16. Eisen A. Amyotrophic lateral sclerosis: evolutionary and other perspectives. Muscle Nerve. 2009;40:297-304.
17. Eisen A, Kuwabara S. The split hand syndrome in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2012;83:399-403.
18. Fitch WT, Braccini SN. Primate laterality and the biology and evolution of human handedness: a review and synthesis. Ann N Y Acad Sci. 2013;1288:70-85.
19. Rose S, Rowland T, Pannek K, Baumann F, Coulthard A, McCombe P, et al. Structural hemispheric asymmetries in the human precentral gyrus hand representation. Neuroscience. 2012;210:211-21.
20. Kapreli E, Athanasopoulos S, Papthanasiou M, van Hecke P, Strimpakos N, Gouliamos A, et al. Lateralization of brain activity during lower limb joints movement: an fMRI study. Neuroimage. 2006;32:1709-21.
21. Filippini N, Douaud G, Mackay CE, Knight S, Talbot K, Turner MR. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology. 2010;75:1645-52.
22. Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neuropsychol Rev. 2005;15:59-71.
23. Bäumer T, Dammann E, Bock F, Klöppel S, Siebner HR, Münchau A. Laterality of interhemispheric inhibition depends on handedness. Exp Brain Res. 2007;180:195-203.
24. Bae JS, Simon NG, Menon P, Vucic S, Kiernan MC. The puzzling case of hyperexcitability in amyotrophic lateral sclerosis. J Clin Neurol. 2013;9:65-74.
25. Benatar M, Wuu J. Presymptomatic studies in ALS: rationale, challenges, and approach. Neurology. 2012;79:1732-9.
26. Turner MR, Kiernan MC. Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis? Amyotroph Lateral Scler. 2012;13:245-50.
27. Swash M. Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry. 2012;83:659-62.
28. Adamo DE, Taufiq A. Establishing hand preference: why does it matter? Hand. 2011;6:295-303.
29. Devine MS, Farrell A, Woodhouse H, McCombe PA, Henderson RD. A developmental perspective on bulbar involvement in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:638-9.