Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis

Muscle and Nerve

Volumn 43, Issue 5, 2011, Pages 636-642

  Körner, Sonja ^a   Kollewe, Katja ^a   Fahlbusch, Marion ^a   Zapf, Antonia ^a   Dengler, Reinhard ^a,b   Krampfl, Klaus ^a   Petri, Susanne ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; COURSE EVALUATION; DISEASE COURSE; FASCICULATION; FEMALE; FLACCID PARALYSIS; HUMAN; LOWER MOTOR NEURON SYMPTOM; MAJOR CLINICAL STUDY; MALE; MOTOR NEUROPATHY; MUSCLE ATROPHY; MUSCLE SPASM; PRIORITY JOURNAL; REFLEX DISORDER; RETROSPECTIVE STUDY; UPPER MOTOR NEURON SYMPTOM;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; COHORT STUDIES; DISEASE PROGRESSION; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCLE, SKELETAL; RETROSPECTIVE STUDIES;

EID: 79955564287     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.21936     Document Type: Article

References (22)

1. Wijesekera LC, Leigh PN. Amyotrophic lateral sclerosis. Orphanet J Rare Dis 2009;4:3.
2. Brooks BR. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical Limits of Amyotrophic Lateral Sclerosis" workshop contributors. J Neurol Sci 1994;124(suppl):96-107.
3. Attarian S, Vedel JP, Pouget J, Schmied A. Cortical versus spinal dysfunction in amyotrophic lateral sclerosis. Muscle Nerve 2006;33:677-690.
4. Eisen A, Kim S, Pant B. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron? Muscle Nerve 1992;15:219-224.
5. Chou SM, Norris FH. Amyotrophic lateral sclerosis: lower motor neuron disease spreading to upper motor neurons. Muscle Nerve 1993; 16:864-869.
6. Fischer LR, Culver DG, Tennant P, Davis AA, Wang M, Castellano-Sanchez A, et al. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 2004;185:232-240.
7. Attarian S, Vedel JP, Pouget J, Schmied A. Progression of cortical and spinal dysfunctions over time in amyotrophic lateral sclerosis. Muscle Nerve 2008;37:364-375.
8. Kiernan JA, Hudson AJ. Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114:843-853.
9. Pamphlett R, Kril J, Hng TM. Motor neuron disease: a primary disorder of corticomotoneurons? Muscle Nerve 1995;18:314-318.
10. Ravits J, Paul P, Jorg C. Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology 2007;68:1571-1575.
11. Ravits J, Laurie P, Fan Y, Moore DH. Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem. Neurology 2007;68:1576-1582.
12. Tourtellotte WW, Syndulko K. Quantifying the neurologic examination: principles, constraints, and opportunities. In: Munsat TL, editor. Quantification of neurologic deficit. Boston: Butterworths; 1989. p 7-16.
13. Monk PN, Shaw PJ. ALS: life and death in a bad neighborhood. Nat Med 2006;12:885-887.
14. van der Graaff MM, de Jong JM, Baas F, de Visser M. Upper motor neuron and extra-motor neuron involvement in amyotrophic lateral sclerosis: a clinical and brain imaging review. Neuromuscul Disord 2009;19:53-58.
15. Brooks BR. The role of axonal transport in neurodegenerative disease spread: a meta-analysis of experimental and clinical poliomyelitis compares with amyotrophic lateral sclerosis. Can J Neurol Sci 1991;18:435-438.
16. Kernich CA. Patient and family fact sheet. Amyotrophic lateral sclerosis: an update. Neurologist 2009;15:113-114.
17. Dengler R. Klinik und Differenzialdiagnose. In: Dengler R, Ludolph A, Zierz S, editors. Amyotrophe Lateralsklerose. Stuttgart: Thieme; 2000. p 59-64.
18. Rosler KM, Truffert A, Hess CW, Magistris MR. Quantification of upper motor neuron loss in amyotrophic lateral sclerosis. Clin Neurophysiol 2000;111:2208-2218.
19. Zoccolella S, Beghi E, Palagano G, Fraddosio A, Samarelli V, Lamberti P, et al. Signs and symptoms at diagnosis of amyotrophic lateral sclerosis: a population-based study in southern Italy. Eur J Neurol 2006;13:789-792.
20. Piao YS, Wakabayashi K, Kakita A, Yamada M, Hayashi S, Morita T, et al. Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000. Brain Pathol 2003;13:10-22.
21. Veldink JH, Kalmijn S, Groeneveld GJ, Titulaer MJ, Wokke JH, Van den Berg LH. Physical activity and the association with sporadic ALS. Neurology 2005;64:241-245.
22. Ravits JM, La Spada AR. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology 2009;73:805-811.