Amorphous formulations of indomethacin and griseofulvin prepared by electrospinning

Molecular Pharmaceutics

Volumn 11, Issue 12, 2014, Pages 4327-4338

  Lopez, Felipe L ^a   Shearman, Gemma C ^b   Gaisford, Simon ^a   Williams, Gareth R ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b LONDON METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

amorphous; electrospinning; griseofulvin; indomethacin; modulated temperature DSC; nanofiber

Indexed keywords

DRUG CARRIER; GRISEOFULVIN; INDOMETACIN;

CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; TEMPERATURE;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; GRISEOFULVIN; INDOMETHACIN; TEMPERATURE;

EID: 84914127195     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500391y     Document Type: Article

References (35)

1. Gaisford, S.; Saunders, M. Essentials of Pharmaceutical Preformulation; Wiley-Blackwell: Hoboken, NJ, 2013.
2. Arinstein, A.; Zussman, E. Postprocesses in tubular electrospun nanofibers Phys. Rev. E 2007, 76, 056303
3. Wu, X. F.; Salkovkiy, Y.; Dzenis, Y. A. Modeling of solvent evaporation from polymer jets in electrospinning Appl. Phys. Lett. 2011, 98, 223108
4. Illangakoon, U. E.; Nazir, T.; Williams, G. R.; Chatterton, N. P. Mebeverine-loaded electrospun nanofibers: physicochemical characterization and dissolution studies J. Pharm. Sci. 2014, 103 (1) 283-92
5. Verreck, G.; Chun, I.; Peeters, J.; Rosenblatt, J.; Brewster, M. E. Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning Pharm. Res. 2003, 20 (5) 810-817
6. Yu, D.-G.; Yu, X.-F.; Zhang, X.-X.; Shen, C.; Brandford White, L.-M. Ultrafine ibuprofen-loaded polyvinylpyrrolidone fiber mats using electrospinning Polym. Int. 2009, 58 (9) 1010-1013
7. Alhusein, N.; Blagbrough, I. S.; De Bank, P. A. Zein/polycaprolactone electrospun matrices for localised controlled delivery of tetracycline Drug Delivery Transl. Res. 2013, 3 (6) 542-550
8. Alhusein, N.; De Bank, P. A.; Blagbrough, I. S.; Bolhuis, A. Killing bacteria within biofilms by sustained release of tetracycline from triple-layered electrospun micro/nanofibre matrices of polycaprolactone and poly(ethylene-co-vinyl acetate) Drug Delivery Transl. Res. 2013, 3 (6) 531-541
9. Williams, G. R.; Chatterton, N. P.; Nazir, T.; Yu, D.-G.; Zhu, L.; Brandford-White, C. J. Electrospun nanofibers in drug delivery: recent developments and perspectives Ther. Delivery 2012, 3 (4) 515-533
10. Natu, M. V.; de Sousa, H. C.; Gil, M. H. Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers Int. J. Pharm. 2010, 397 (1-2) 50-8
11. Vyazovkin, S.; Dranca, I. Physical stability and relaxation of amorphous indomethacin J. Phys. Chem. B 2005, 109, 18637-18644
12. Zhou, D.; Zhang, G. G. Z.; Law, D.; Grant, D. J. W.; Schmitt, E. A. Thermodynamics, molecular mobility and crystallization kinetics of amorphous griseofulvin Mol. Pharmaceutics 2008, 5 (6) 927-936
13. Nagy, Z. K.; Nyul, K.; Wagner, I.; Molnar, K.; Marosi, G. Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl eXPRESS Polym. Lett. 2010, 4 (12) 763-772
14. Vrbata, P.; Berka, P.; Stranska, D.; Dolezal, P.; Musilova, M.; Cizinska, L. Electrospun drug loaded membranes for sublingual administration of Sumatriptan and naproxen Int. J. Pharm. 2013, 457 (1) 168-76
15. Taepaiboon, P.; Rungsardthong, U.; Supaphol, P. Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs Nanotechnol. 2006, 17 (9) 2317-2329
16. Pornsopone, V.; Supaphol, P.; Rangkupan, R.; Tantayanon, S. Electrospun methacrylate-based copolymer/indomethacin fibers and their release characteristics of indomethacin J. Polym. Res. 2006, 14 (1) 53-59
17. Tungprapa, S.; Jangchud, I.; Supaphol, P. Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats Polymer 2007, 48 (17) 5030-5041
18. Brettmann, B. K.; Myerson, A. S.; Trout, B. L. Solid-state nuclear magnetic resonance study of the physical stability of electrospun drug and polymer solid solutions J. Pharm. Sci. 2012, 101 (6) 2185-93
19. Brettmann, B.; Bell, E.; Myerson, A.; Trout, B. Solid-state NMR characterization of high-loading solid solutions of API and excipients formed by electrospinning J. Pharm. Sci. 2012, 101 (4) 1538-45
20. Rasekh, M.; Karavasili, C.; Soong, Y. L.; Bouropoulos, N.; Morris, M.; Armitage, D.; Li, X.; Fatouros, D. G.; Ahmad, Z. Electrospun PVP-indomethacin constituents for transdermal dressings and drug delivery devices Int. J. Pharm. 2014, 473 (1-2) 95-104
21. Wang, L.; Wang, M.; Topham, P. D.; Huang, Y. Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics RSC Adv. 2012, 2 (6) 2433
22. Dott, C.; Tyagi, C.; Tomar, L. K.; Choonara, Y. E.; Kumar, P.; du Toit, L. C.; Pillay, V. A Mucoadhesive Electrospun Nanofibrous Matrix for Rapid Oramucosal Drug Delivery J. Nanomater. 2013, 924947
23. El-Badry, M.; Fetih, G.; Fathy, M. Improvement of solubility and dissolution rate of indomethacin by solid dispersions in Gelucire 50/13 and PEG4000 Saudi Pharm. J. 2009, 17 (3) 217-25
24. Mosharraf, M.; Nystrom, C. The effect of dry mixing on the apparent solubility of hydrophobic, sparingly soluble drugs Eur. J. Pharm. Sci. 1999, 9, 145-156
25. Mahieu, A.; Willart, J.-f.; Dudognon, E.; Eddleston, M. D.; Jones, W. On the polymorphism of griseofulvin: Identification of two additionalpolymorphs J. Pharm. Sci. 2013, 102 (2) 462-468
26. Verdonck, E.; Schaap, K.; Thomas, L. C. A discussion of the principles and applications of modulated temperature DSC (MTDSC) Int. J. Pharm. 1999, 192 (1) 3-20
27. An, L.; He, D.; Jing, J.; Wang, Z.; Yu, D.; Jiang, B. Effects of molecular weight and interaction parameter on the glass transition temperature of polystyrene mixtures and its blends with polystyrene/poly (2,6-dimethyl- p -phenylene oxide) Eur. Polym. J. 1997, 33 (9) 1523-1528
28. Seo, J.-A.; Oh, J.; Kim, H. K.; Hwang, Y.-H. Study of glass transition temperatures in sugar mixtures J. Korean Phys. Soc. 2005, 46 (3) 606-609
29. Chokshi, R. J.; Shah, N. H.; Sandhu, H. K.; Malick, A. W.; Zia, H. Stabilization of low glass transition temperature indomethacin formulations: Impact of polymer-type and its concentration J. Pharm. Sci. 2008, 97 (6) 2286-2298
30. Al Obaidi, H.; Buckton, G. Evaluation of Griseofulvin Binary and Ternary Solid Dispersions with HPMCAS AAPS PharmSciTech 2009, 10 (4) 1172-1177
31. PrudHomme, R. E. Miscibility phenomena in polyester/chlorinated polymer blends Polym. Eng. Sci. 1982, 22 (2) 90-95
32. Ritger, P. L.; Peppas, N. A. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices J. Controlled Release 1987, 5, 37-42
33. Aghdam, R. M.; Najarian, S.; Shakhesi, S.; Khanlari, S.; Shaabani, K.; Sharifi, S. Investigating the effect of PGA on physical and mechanical properties of electrospun PCL/PGA blend nanofibers J. Appl. Polym. Sci. 2012, 124 (1) 123-131
34. Xiang, T. X.; Anderson, B. D. Molecular dynamics simulation of amorphous indomethacin-poly(vinylpyrrolidone) glasses: solubility and hydrogen bonding interactions J. Pharm. Sci. 2013, 102 (3) 876-91
35. Vasanthavada, M.; Tong, W.-Q.; Joshi, Y.; Kislalioglu, M. S. Phase Behavior of Amorphous Molecular Dispersions II: Role of Hydrogen Bonding in Solid Solubility and Phase Separation Kinetics Pharm. Res. 2005, 22 (3) 440-448