메뉴 건너뛰기




Volumn 22, Issue 10, 2014, Pages 728-734

LEF-1 is frequently expressed in colorectal carcinoma and not in other gastrointestinal tract adenocarcinomas: An immunohistochemical survey of 602 gastrointestinal tract neoplasms

Author keywords

BRAF; Colorectal carcinoma; KRAS; LEF 1; MSI; Prognosis

Indexed keywords

CDX2 PROTEIN, HUMAN; CYTOKERATIN 20; HOMEODOMAIN PROTEIN; KRAS PROTEIN, HUMAN; KRT20 PROTEIN, HUMAN; LEF1 PROTEIN, HUMAN; LYMPHOID ENHANCER FACTOR 1; ONCOPROTEIN; RAS PROTEIN; TUMOR MARKER;

EID: 84914122707     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0000000000000109     Document Type: Article
Times cited : (13)

References (29)
  • 1
    • 33845608798 scopus 로고    scopus 로고
    • Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    • Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology. 2007;50:113-130.
    • (2007) Histopathology. , vol.50 , pp. 113-130
    • Jass, J.R.1
  • 2
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997;386:623-627.
    • (1997) Nature. , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 3
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut. 2009;58:90-96.
    • (2009) Gut. , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 4
    • 84856191525 scopus 로고    scopus 로고
    • Dysregulation of Wnt/betacatenin signaling in gastrointestinal cancers
    • White BD, Chien AJ, Dawson DW. Dysregulation of Wnt/betacatenin signaling in gastrointestinal cancers. Gastroenterology. 2012;142:219-232.
    • (2012) Gastroenterology. , vol.142 , pp. 219-232
    • White, B.D.1    Chien, A.J.2    Dawson, D.W.3
  • 5
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434:843-850.
    • (2005) Nature. , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 6
    • 77953489241 scopus 로고    scopus 로고
    • Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability
    • Albuquerque C, Baltazar C, Filipe B, et al. Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer. 2010;49:746-759.
    • (2010) Genes Chromosomes Cancer. , vol.49 , pp. 746-759
    • Albuquerque, C.1    Baltazar, C.2    Filipe, B.3
  • 7
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    • Brabletz T, Jung A, Hermann K, et al. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract. 1998;194:701-704.
    • (1998) Pathol Res Pract. , vol.194 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3
  • 8
    • 0037173081 scopus 로고    scopus 로고
    • Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
    • Anderson CB, Neufeld KL, White RL. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci U S A. 2002;99:8683-8688.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 8683-8688
    • Anderson, C.B.1    Neufeld, K.L.2    White, R.L.3
  • 9
    • 0034724186 scopus 로고    scopus 로고
    • APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"
    • Rowan AJ, Lamlum H, Ilyas M, et al. APC mutations in sporadic colorectal tumors: a mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A. 2000;97:3352-3357.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , pp. 3352-3357
    • Rowan, A.J.1    Lamlum, H.2    Ilyas, M.3
  • 11
    • 0025865915 scopus 로고
    • A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer
    • Waterman ML, Fischer WH, Jones KA. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Genes Dev. 1991;5:656-669.
    • (1991) Genes Dev. , vol.5 , pp. 656-669
    • Waterman, M.L.1    Fischer, W.H.2    Jones, K.A.3
  • 12
    • 0025794148 scopus 로고
    • LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
    • Travis A, Amsterdam A, Belanger C, et al. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]. Genes Dev. 1991;5:880-894.
    • (1991) Genes Dev. , vol.5 , pp. 880-894
    • Travis, A.1    Amsterdam, A.2    Belanger, C.3
  • 13
    • 80455174774 scopus 로고    scopus 로고
    • Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia/small lymphocytic lymphoma in small B-cell lymphomas
    • Tandon B, Peterson L, Gao J, et al. Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia/small lymphocytic lymphoma in small B-cell lymphomas. Mod Pathol. 2011;24:1433-1443.
    • (2011) Mod Pathol. , vol.24 , pp. 1433-1443
    • Tandon, B.1    Peterson, L.2    Gao, J.3
  • 14
    • 84875189534 scopus 로고    scopus 로고
    • Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma
    • Walther N, Ulrich A, Vockerodt M, et al. Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma. Am J Pathol. 2013;182:1092-1098.
    • (2013) Am J Pathol. , vol.182 , pp. 1092-1098
    • Walther, N.1    Ulrich, A.2    Vockerodt, M.3
  • 15
    • 83455196188 scopus 로고    scopus 로고
    • Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
    • Kuhnl A, Gokbuget N, Kaiser M, et al. Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia. Blood. 2011;118:6362-6367.
    • (2011) Blood. , vol.118 , pp. 6362-6367
    • Kuhnl, A.1    Gokbuget, N.2    Kaiser, M.3
  • 16
    • 78549285669 scopus 로고    scopus 로고
    • LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer
    • Kriegl L, Horst D, Reiche JA, et al. LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. J Transl Med. 2010;8:123-131.
    • (2010) J Transl Med. , vol.8 , pp. 123-131
    • Kriegl, L.1    Horst, D.2    Reiche, J.A.3
  • 17
    • 79952077027 scopus 로고    scopus 로고
    • Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker
    • Lin AY, Chua MS, Choi YL, et al. Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. PLoS One. 2011;6:e16636.
    • (2011) PLoS One. , vol.6 , pp. e16636
    • Lin, A.Y.1    Chua, M.S.2    Choi, Y.L.3
  • 18
    • 84890335405 scopus 로고    scopus 로고
    • Increased LEF1 expression and decreased notch2 expression are strong predictors of poor outcomes in colorectal cancer patients
    • Wang WJ, Yao Y, Jiang LL, et al. Increased LEF1 expression and decreased notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers. 2013;35:395-405.
    • (2013) Dis Markers. , vol.35 , pp. 395-405
    • Wang, W.J.1    Yao, Y.2    Jiang, L.L.3
  • 19
    • 84884514392 scopus 로고    scopus 로고
    • Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatelliteunstable colorectal cancer
    • Kim JH, Rhee YY, Bae JM, et al. Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatelliteunstable colorectal cancer. Am J Surg Pathol. 2013;37:1532-1541.
    • (2013) Am J Surg Pathol. , vol.37 , pp. 1532-1541
    • Kim, J.H.1    Rhee, Y.Y.2    Bae, J.M.3
  • 20
    • 57749112183 scopus 로고    scopus 로고
    • Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
    • Lugli A, Tzankov A, Zlobec I, et al. Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod Pathol. 2008;21:1403-1412.
    • (2008) Mod Pathol. , vol.21 , pp. 1403-1412
    • Lugli, A.1    Tzankov, A.2    Zlobec, I.3
  • 21
    • 2542476370 scopus 로고    scopus 로고
    • Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability
    • McGregor DK, Wu TT, Rashid A, et al. Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability. Am J Surg Pathol. 2004;28:712-718.
    • (2004) Am J Surg Pathol. , vol.28 , pp. 712-718
    • McGregor, D.K.1    Wu, T.T.2    Rashid, A.3
  • 22
    • 80052926952 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features
    • Zlobec I, Bihl M, Foerster A, et al. Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. J Pathol. 2011;225:336-343.
    • (2011) J Pathol. , vol.225 , pp. 336-343
    • Zlobec, I.1    Bihl, M.2    Foerster, A.3
  • 23
    • 84858076248 scopus 로고    scopus 로고
    • Aberrant pattern of the cytokeratin 7/cytokeratin 20 immunophenotype in colorectal adenocarcinomas with BRAF mutations
    • Gurzu S, Jung I. Aberrant pattern of the cytokeratin 7/cytokeratin 20 immunophenotype in colorectal adenocarcinomas with BRAF mutations. Pathol Res Pract. 2012;208:163-166.
    • (2012) Pathol Res Pract. , vol.208 , pp. 163-166
    • Gurzu, S.1    Jung, I.2
  • 24
    • 84874586909 scopus 로고    scopus 로고
    • Serrated pathway adenocarcinomas: Molecular and immunohistochemical insights into their recognition
    • Gurzu S, Szentirmay Z, Toth E, et al. Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition. PLoS One. 2013;8:e57699.
    • (2013) PLoS One. , vol.8 , pp. e57699
    • Gurzu, S.1    Szentirmay, Z.2    Toth, E.3
  • 25
    • 0036840216 scopus 로고    scopus 로고
    • Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays
    • Liu CL, Prapong W, Natkunam Y, et al. Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays. Am J Pathol. 2002;161:1557-1565.
    • (2002) Am J Pathol. , vol.161 , pp. 1557-1565
    • Liu, C.L.1    Prapong, W.2    Natkunam, Y.3
  • 26
    • 0035185894 scopus 로고    scopus 로고
    • Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: Parallel pathways of tumorigenesis
    • Young J, Simms LA, Biden KG, et al. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol. 2001;159:2107-2116.
    • (2001) Am J Pathol. , vol.159 , pp. 2107-2116
    • Young, J.1    Simms, L.A.2    Biden, K.G.3
  • 27
    • 0025424347 scopus 로고
    • Crohn's-like lymphoid reaction and colorectal carcinoma: A potential histologic prognosticator
    • Graham DM, Appelman HD. Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator. Mod Pathol. 1990;3:332-335.
    • (1990) Mod Pathol. , vol.3 , pp. 332-335
    • Graham, D.M.1    Appelman, H.D.2
  • 28
    • 59149092031 scopus 로고    scopus 로고
    • Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer
    • Wang LM, Kevans D, Mulcahy H, et al. Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am J Surg Pathol. 2009;33:134-141.
    • (2009) Am J Surg Pathol. , vol.33 , pp. 134-141
    • Wang, L.M.1    Kevans, D.2    Mulcahy, H.3
  • 29
    • 84859885193 scopus 로고    scopus 로고
    • BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: An aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features
    • Pai RK, Jayachandran P, Koong AC, et al. BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Am J Surg Pathol. 2012;36:744-752.
    • (2012) Am J Surg Pathol. , vol.36 , pp. 744-752
    • Pai, R.K.1    Jayachandran, P.2    Koong, A.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.