Kinetics of chlorambucil in vitro: Effects of fluid matrix, human gastric juice, plasma proteins and red cells

Chemico-Biological Interactions

Volumn 103, Issue 3, 1997, Pages 187-198

  Lof K ^a   Hovinen, J ^b   Reinikainen, P ^a   Vilpo, L M ^a   Seppala E ^a   Vilpo, J A ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Chlorambucil; Chlorambucil phosphates; Drug metabolism; Hydrolysis; Plasma protein binding; Red cell incorporation

Indexed keywords

CHLORAMBUCIL; DRUG METABOLITE; PHENYLACETIC ACID DERIVATIVE;

ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DEGRADATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG STABILITY; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PLASMA PROTEIN BINDING; STOMACH JUICE;

BLOOD PROTEINS; CHLORAMBUCIL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ERYTHROCYTES; GASTRIC JUICE; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PROTEIN BINDING; SODIUM CHLORIDE; WATER;

EID: 0031567113     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)03758-7     Document Type: Article

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