Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice

Gastroenterology

Volumn 147, Issue 6, 2014, Pages 1378-1392

  Yoshida, Shuhei ^a   Ikenaga, Naoki ^a   Liu, Susan B ^a   Peng, Zhen Wei ^a   Chung, Jeanhee ^a   Sverdlov, Deanna Y ^a   Miyamoto, Makoto ^a   Kim, Yong Ook ^b   Ogawa, Shinji ^c   Arch, Robert H ^c   Schuppan, Detlef ^a,b   Popov, Yury ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c PFIZER INC   (United States)

Author keywords

Chronic Liver Injury; Mouse Model; PBC; PSC

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BETA6 INTEGRIN; BILIRUBIN; COLLAGEN; COLLAGENASE 3; FIBRINOGEN RECEPTOR; GELATINASE A; GELATINASE B; IMATINIB; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MOR8457; MULTIDRUG RESISTANCE PROTEIN 3; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROCOLLAGEN; PROCOLLAGEN ALPHA1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; MULTIDRUG RESISTANCE PROTEIN; NEUTRALIZING ANTIBODY; P-GLYCOPROTEIN 2;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; STELLATE CELL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; UPREGULATION; AGED; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEPATIC DUCT; IMMUNOLOGY; LIVER CIRRHOSIS; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ASPIRIN; BILE DUCTS, EXTRAHEPATIC; BLOOD PLATELETS; DISEASE MODELS, ANIMAL; FEMALE; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; P-GLYCOPROTEINS; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-SIS; RNA, MESSENGER;

EID: 84913580343     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.08.038     Document Type: Article

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