In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Reproduction

Volumn 148, Issue 6, 2014, Pages 635-646

  Vested, Anne ^a   Ramlau Hansen, Cecilia H ^a,b   Olsen, Sjurdur F ^c   Bonde, Jens Peter ^d   Støvring, Henrik ^e   Kristensen, Susanne L ^a   Halldorsson, Thorhallur I ^c,f   Rantakokko, Panu ^g   Kiviranta, Hannu ^g   Ernst, Emil H ^b   Toft, Gunnar ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e Bartholins Allé 2 Building 1261 ^*  (Denmark)

^f UNIVERSITY OF ICELAND   (Iceland)

^g NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; POLYCHLORINATED BIPHENYL; CHLORINATED HYDROCARBON; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; POLLUTANT; TESTOSTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DENMARK; ENVIRONMENTAL EXPOSURE; FOLLOW UP; GAS CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MAJOR CLINICAL STUDY; MALE; MATERNAL BLOOD; MATERNAL SERUM; PERSISTENT ORGANIC POLLUTANT; PERSISTENT ORGANOCHLORINE POLLUTANT; REPRODUCTIVE HEALTH; SEMEN ANALYSIS; SPERM QUALITY; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; ADVERSE EFFECTS; BLOOD; COHORT ANALYSIS; FEMALE; LONGITUDINAL STUDY; POLLUTANT; PREGNANCY; PRENATAL EXPOSURE; QUESTIONNAIRE; RETROSPECTIVE STUDY; YOUNG ADULT;

COHORT STUDIES; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; HYDROCARBONS, CHLORINATED; LONGITUDINAL STUDIES; LUTEINIZING HORMONE; MALE; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTIVE HEALTH; RETROSPECTIVE STUDIES; SEMEN ANALYSIS; SURVEYS AND QUESTIONNAIRES; TESTOSTERONE; YOUNG ADULT;

EID: 84913570731     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-13-0488     Document Type: Article

References (55)

1. Aneck-Hahn NH, Schulenburg GW, Bornman MS, Farias P & de Jager C 2007 Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa. Journal of Andrology 28 423-434. (doi:10.2164/jandrol. 106.001701)
2. Axelsson J, Rylander L, Rignell-Hydbom A & Giwercman A 2011 No secular trend over the last decade in sperm counts among Swedish men from the general population. Human Reproduction 26 1012-1016. (doi:10.1093/humrep/der045)
3. Bhatia R, Shiau R, Petreas M, Weintraub JM, Farhang L & Eskenazi B 2005 Organochlorine pesticides and male genital anomalies in the child health and development studies. Environmental Health Perspectives 113 220-224. (doi:10.1289/ehp.7382)
4. Bonde JP, Giwercman A & Ernst E 1996 Identifying environmental risk to male reproductive function by occupational sperm studies: logistics and design options. Occupational and Environmental Medicine 53 511-519. (doi:10.1136/oem.53.8.511)
5. Bonde JP, Ernst E, Jensen TK, Hjollund NH, Kolstad H, Henriksen TB, Scheike T, Giwercman A, Olsen J & Skakkebaek NE 1998 Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 352 1172-1177(doi:10.1016/S0140- 6736(97)10514-1)
6. (doi:10.1016/S0140- 6736(97)10514-1) Brucker-Davis F, Wagner-Mahler K, Delattre I, Ducot B, Ferrari P, Bongain A, Kurzenne JY, Mas JC, Fenichel P & Cryptorchidism Study Group from Nice Area 2008 Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations. Human Reproduction 23 1708-1718. (doi:10.1093/humrep/den186)
7. Christiansen S, Scholze M, Axelstad M, Boberg J, Kortenkamp A & Hass U 2008 Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. International Journal of Andrology 31 241-248. (doi:10.1111/j.1365-2605.2008.00866.x)
8. Cook MB, Trabert B & McGlynn KA 2011 Organochlorine compounds and testicular dysgenesis syndrome: human data. International Journal of Andrology 34 e68-e84 discussion e84-5. (doi:10.1111/j.1365-2605. 2011.01171.x)
9. De Jager C, Farias P, Barraza-Villarreal A, Avila MH, Ayotte P, Dewailly E, Dombrowski C, Rousseau F, Sanchez VD & Bailey JL 2006 Reduced seminal parameters associated with environmental DDT exposure and p,p 0 -DDE concentrations in men in Chiapas, Mexico: a cross-sectional study. Journal of Andrology 27 16-27. (doi:10.2164/ jandrol.05121)
10. Fernandez MF, Duran I, Olea N, Avivar C, Vierula M, Toppari J, Skakkebaek NE & Jørgensen N 2011 Semen quality and reproductive hormone levels in men from Southern Spain. International Journal of Andrology 35 1-10. (doi:10.1111/j.1365-2605.2010.01131.x)
11. Gasull M, de Basea MB, Puigdomènech E, Pumarega J & Porta M 2011 Empirical analyses of the influence of diet on human concentrations of persistent organic pollutants: a systematic review of all studies conducted in Spain. Environment International 37 1226-1235. (doi:10. 1016/j.envint.2011.05.008)
12. Guo YL, Hsu PC, Hsu CC & Lambert GH 2000 Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 356 1240-1241. (doi:10.1016/S0140-6736(00)02792-6)
13. Haugen TB, Tefre T, Malm G, Jonsson BA, Rylander L, Hagmar L, Bjorsvik C, Henrichsen T, Saether T, Figenschau Y et al. 2011 Differences in serum levels of CB-153 and p,p 0 -DDE, and reproductive parameters between men living south and north in Norway. Reproductive Toxicology 32 261-267. (doi:10.1016/j.reprotox.2011.06.072)
14. Hauser R, Chen Z, Pothier L, Ryan L & Altshul L 2003 The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p, p 0 -DDE. Environmental Health Perspectives 111 1505-1511. (doi:10.1289/ehp.6175)
15. Jacobson JL, Fein GG, Jacobson SW, Schwartz PM & Dowler JK 1984 The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk. American Journal of Public Health 74 378-379. (doi:10.2105/AJPH.74. 4.378)
16. Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, Andersson AM, Haugen TB, Horte A, Jensen TK et al. 2002 East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Human Reproduction 17 2199-2208. (doi:10.1093/humrep/17.8.2199)
17. Jørgensen N, Joensen UN, Jensen TK, Jensen MB, Almstrup K, Olesen IA, Juul A, Andersson AM, Carlsen E, Petersen JH et al. 2012 Human semen quality in the new millennium: a prospective cross-sectional populationbased study of 4867 men. BMJ Open 2 1-13. (doi:10.1136/bmjopen- 2012-000990)
18. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA &Wilson EM 1995 Persistent DDT metabolite p,p 0 -DDE is a potent androgen receptor antagonist. Nature 375 581-585. (doi:10.1038/375581a0)
19. Koponen J, Rantakokko P, Airaksinen R & Kiviranta H 2013 Determination of selected perfluorinated alkyl acids and persistent organic pollutants from a small volume human serum sample relevant for epidemiological studies. Journal of Chromatography. A 1309 48-55. (doi:10.1016/j. chroma.2013.07.064)
20. Kortenkamp A 2008 Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology. International Journal of Andrology 31 233-240. (doi:10.1111/j.1365-2605.2007.00862.x)
21. Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O et al.2012 Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures. International Journal of Andrology 35 294-302. (doi:10.1111/j.1365- 2605.2012.01268.x)
22. Kuriyama SN & Chahoud I 2004 In utero exposure to low-dose 2,3 0, 4,4 0, 5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Toxicology 202 185-197. (doi:10.1016/ j.tox.2004.05.006)
23. Longnecker MP, Klebanoff MA, Brock JW, Zhou H, Gray KA, Needham LL & Wilcox AJ 2002 Maternal serum level of 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring. American Journal of Epidemiology 155 313-322. (doi:10.1093/aje/155.4.313)
24. McGlynn KA, Guo X, Graubard BI, Brock JW, Klebanoff MA & Longnecker MP 2009 Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring. Environmental Health Perspectives 117 1472-1476. (doi:10.1289/ehp. 0800389)
25. Menkveld R, Stander FS, Kotze TJ, Kruger TF & van Zyl JA 1990 The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Human Reproduction 5 586-592.
26. Mocarelli P, Gerthoux PM, Needham LL, Patterson DG Jr, Limonta G, Falbo R, Signorini S, Bertona M, Crespi C, Sarto C et al. 2011 Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environmental Health Perspectives 119 713-718. (doi:10.1289/ ehp.1002134)
27. Olsen SF, Hansen HS, Sandstrom B & Jensen B 1995a Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. British Journal of Nutrition 73 387-395. (doi:10.1079/ BJN19950041)
28. Olsen SF, Hansen HS, Secher NJ, Jensen B & Sandstrom B 1995b Gestation length and birth weight in relation to intake of marine n-3 fatty acids. British Journal of Nutrition 73 397-404. (doi:10.1079/BJN19950042)
29. PaaschU, Salzbrunn A, GlanderHJ, Plambeck K, Salzbrunn H, Grunewald S, Stucke J, VierulaM, Skakkebaek NE & JørgensenN 2008 Semen quality in sub-fertile range for a significant proportion of young men fromthe general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. International Journal of Andrology 31 93-102. (doi:10.1111/j.1365-2605.2007.00860.x)
30. Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Rhind SM, Zhang Z & Borromeo V 2012 Effects of polychlorinated biphenyls in CD-1 mice: reproductive toxicity and intergenerational transmission. Toxicological Sciences 126 213-226. (doi:10.1093/toxsci/kfr327)
31. Punab M, Zilaitiene B, Jørgensen N, Horte A, Matulevicius V, Peetsalu A & Skakkebaek NE 2002 Regional differences in semen qualities in the Baltic region. International Journal of Andrology 25 243-252. (doi:10. 1046/j.1365-2605.2002.00359.x)
32. Ramlau-Hansen CH, Thulstrup AM, Storgaard L, Toft G, Olsen J & Bonde JP 2007a Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study American Journal of Epidemiology 165 1372-1379. (doi:10.1093/aje/kwm032)
33. Ramlau-Hansen CH, Thulstrup AM, Bonde JP & Ernst E 2007b Is selfmeasuring of testicular volume by a Prader orchidometer a valid method? Fertility and Sterility 87 1480-1482. (doi:10.1016/j.fertnstert.2006.11.032)
34. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, Toft G & Bonde JP 2007 c Is smoking a risk factor for decreased semen quality? A cross-sectional analysis Human Reproduction 22 188-196. (doi:10. 1093/humrep/del364)
35. Richthoff J, Rylander L, Hagmar L, Malm J & Giwercman A 2002 Higher sperm counts in Southern Sweden compared with Denmark. Human Reproduction 17 2468-2473. (doi:10.1093/humrep/17.9.2468)
36. Richthoff J, Rylander L, Jonsson BA, Akesson H, Hagmar L, Nilsson-Ehle P, Stridsberg M & Giwercman A 2003 Serum levels of 2,2 0, 4,4 0, 5, 5 0 -hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environmental Health Perspectives 111 409-413. (doi:10.1289/ehp.5767)
37. Rignell-Hydbom A, Lindh CH, Dillner J, Jonsson BA & Rylander L 2012 A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadias. PLoS ONE 7 e44767. (doi:10.1371/journal.pone.0044767)
38. Rozati R, Reddy PP, Reddanna P & Mujtaba R 2002 Role of environmental estrogens in the deterioration of male factor fertility. Fertility and Sterility 78 1187-1194. (doi:10.1016/S0015-0282(02)04389-3)
39. Rylander L, Nilsson-Ehle P & Hagmar L 2006 A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids. Chemosphere 62 333-336. (doi:10.1016/j.chemosphere. 2005.04.107)
40. Safe S 1990 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology 21 51-88. (doi:10.3109/10408449009089873)
41. Saxena MC, Siddiqui MK, Bhargava AK, Murti CR & KuttyD 1981 Placental transfer of pesticides in humans. Archives of Toxicology 48 127-134. (doi:10.1007/BF00310482)
42. Seegal RF, Fitzgerald EF, Hills EA, Wolff MS, Haase RF, Todd AC, Parsons P, Molho ES, Higgins DS, Factor SA et al. 2011 Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval. Journal of Exposure Science and Environmental Epidemiology 21 234-246. (doi:10.1038/jes.2010.3)
43. Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M et al. 2013 BMI in relation to sperm count: an updated systematic review and collaborative metaanalysis. Human Reproduction Update 19 221-231. (doi:10.1093/ humupd/dms050)
44. Sharpe RM, McKinnell C, Kivlin C & Fisher JS 2003 Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 125 769-784. (doi:10.1530/ rep.0.1250769)
45. Skakkebaek NE, Rajpert-De Meyts E & Main KM 2001 Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Human Reproduction 16 972-978. (doi:10. 1093/humrep/16.5.972)
46. Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM & Carpenter JR 2009 Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338 b2393. (doi:10.1136/bmj.b2393)
47. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A, Lindh CH, Pedersen HS, Ludwicki JK, Lesovoy V, Hagmar L et al. 2006 Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 17 450-458. (doi:10.1097/01.ede.0000221769.41028.d2)
48. Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr, Jegou B, Jensen TK, Jouannet P, Keiding N et al. 1996 Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives 104 (Suppl 4) 741-803. (doi:10.1289/ehp.96104s4741)
49. Toppari J & Skakkebaek NE 1998 Sexual differentiation and environmental endocrine disrupters. Bailliere's Clinical Endocrinology and Metabolism 12 143-156. (doi:10.1016/S0950-351X(98)80529-6)
50. Vermeulen A, Verdonck L & Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 84 3666-3667. (doi:10.1210/ jcem.84.10.6079)
51. Vested A, Ramlau-Hansen CH, Bonde JP, Thulstrup AM, Kristensen SL & Toft G 2011 A comparison of conventional and computer-assisted semen analysis (CRISMAS software) using samples from 166 young Danish men. Asian Journal of Andrology 13 453-458. (doi:10.1038/aja.2011.14)
52. Vested A, Ramlau-Hansen CH, Olsen SF, Bonde JP, Kristensen SL, Halldorsson TI, Becher G, Haug LS, Ernst EH & Toft G 2013 Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men. Environmental Health Perspectives 121 453-458. (doi:10.1289/ehp.1205118)
53. Virtanen HE, Koskenniemi JJ, Sundqvist E, Main KM, Kiviranta H, Tuomisto JT, Tuomisto J, Viluksela M, Vartiainen T, Skakkebaek NE et al. 2012 Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta. International Journal of Andrology 35 283-293. (doi:10.1111/j.1365-2605.2011.01233.x)
54. Wolff MS, Zeleniuch-Jacquotte A, Dubin N & Toniolo P 2000 Risk of breast cancer and organochlorine exposure. Cancer Epidemiology, Biomarkers & Prevention 9 271-277.
55. th ed. Cambridge, UK: Cambridge University Press.